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Manuscript Submission Deadline 31 January 2024

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One of the fundamental stages of memory processing is consolidation in which initially labile memories are gradually moved to a more fixed state. Memory consolidation is a vulnerable stage of memory traces, and its stabilization could be affected by memory modulators depending on memory types. Synchronizing individual chronotypes, that vary with genetics, age and sex, with sleep timing and social time leads to better memory consolidation in health and disease. Recent research suggests that pharmacological interventions can have a significant impact on the process of memory consolidation. There are several different types of pharmacological interventions that have been shown to affect memory consolidation. For example, N-methyl-D-aspartate (NMDA) receptor agonists, such as D-cycloserine, have been found to enhance the consolidation of fear memories. Other classes of drugs, such as anti-inflammatory agents and glucocorticoids, have also been shown to influence the consolidation process. Furthermore, pharmacological interventions can be used to modulate other factors that influence the consolidation of memories, such as sleep quality. Disruptions in sleep can negatively affect memory consolidation, but medications that improve sleep can improve these outcomes. Women experience changes in hormonal levels during pregnancy and menopause that may affect memory consolidation. The role of circadian rhythm in memory consolidation is also relevant. Melatonin is a naturally occurring hormone that regulates sleep and wake cycles, and studies have suggested that it can modulate memory consolidation. The social environment can also have an impact on memory consolidation. Researchers have investigated how modulators of neurotransmitters like dopamine or oxytocin, can affect memory consolidation in social contexts.

This article collection seeks to explore the broad impact of memory modulators, specifically pharmacological interventions, on memory consolidation. Further research in this area is needed to better understand the mechanisms behind these different interventions, as well as their clinical implications. This article collection will draw on the expertise of researchers and clinicians across diverse fields, including pharmacology, neuroscience, and sleep medicine to provide a comprehensive and multidisciplinary perspective on pharmacological interventions and memory consolidation outcomes.

This Article Collection welcomes insights on, but not limited to, the following themes:

1. Pharmacological interventions that modify memory storage.

2. Characterization of process of memory storage across the lifespan.

3. Impact of sex and reproductive stage on memory consolidation.

4. Role of circadian rhythm on memory consolidation.

5. Effect of sleep on memory storage.

6. Interaction between the social environment and memory consolidation.

7. Memory consolidation in mental and neurodegenerative diseases.

Keywords: ontogenesis, memory, consolidation, pharmacology, reproductive stage, circadian rhythm, sleep, neurodegenerative


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

One of the fundamental stages of memory processing is consolidation in which initially labile memories are gradually moved to a more fixed state. Memory consolidation is a vulnerable stage of memory traces, and its stabilization could be affected by memory modulators depending on memory types. Synchronizing individual chronotypes, that vary with genetics, age and sex, with sleep timing and social time leads to better memory consolidation in health and disease. Recent research suggests that pharmacological interventions can have a significant impact on the process of memory consolidation. There are several different types of pharmacological interventions that have been shown to affect memory consolidation. For example, N-methyl-D-aspartate (NMDA) receptor agonists, such as D-cycloserine, have been found to enhance the consolidation of fear memories. Other classes of drugs, such as anti-inflammatory agents and glucocorticoids, have also been shown to influence the consolidation process. Furthermore, pharmacological interventions can be used to modulate other factors that influence the consolidation of memories, such as sleep quality. Disruptions in sleep can negatively affect memory consolidation, but medications that improve sleep can improve these outcomes. Women experience changes in hormonal levels during pregnancy and menopause that may affect memory consolidation. The role of circadian rhythm in memory consolidation is also relevant. Melatonin is a naturally occurring hormone that regulates sleep and wake cycles, and studies have suggested that it can modulate memory consolidation. The social environment can also have an impact on memory consolidation. Researchers have investigated how modulators of neurotransmitters like dopamine or oxytocin, can affect memory consolidation in social contexts.

This article collection seeks to explore the broad impact of memory modulators, specifically pharmacological interventions, on memory consolidation. Further research in this area is needed to better understand the mechanisms behind these different interventions, as well as their clinical implications. This article collection will draw on the expertise of researchers and clinicians across diverse fields, including pharmacology, neuroscience, and sleep medicine to provide a comprehensive and multidisciplinary perspective on pharmacological interventions and memory consolidation outcomes.

This Article Collection welcomes insights on, but not limited to, the following themes:

1. Pharmacological interventions that modify memory storage.

2. Characterization of process of memory storage across the lifespan.

3. Impact of sex and reproductive stage on memory consolidation.

4. Role of circadian rhythm on memory consolidation.

5. Effect of sleep on memory storage.

6. Interaction between the social environment and memory consolidation.

7. Memory consolidation in mental and neurodegenerative diseases.

Keywords: ontogenesis, memory, consolidation, pharmacology, reproductive stage, circadian rhythm, sleep, neurodegenerative


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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