It is well known that nutritional approaches are widely considered vital ways to maintain health in clinical practice guidelines. Betaine (N,N,N-trimethylglycine) is a non-hazardous naturally occurring nutrient and an amino-acid derivative presenting in many food components. In addition to serving as an important methyl donor for DNA methylation, betaine is also an intermediate in choline metabolism and participates in the regulation of the methionine-homocysteine cycle, one-carbon metabolism, and osmotic pressure. Previous evidence suggests that circulating betaine is significantly correlated with the occurrence of various diseases, including Alzheimer's disease, cardiovascular disease, and cancers, and its supplementation may contribute to the prevention or amelioration of obesity and associated complications. However, the association of betaine with more diseases still needs to be addressed, particularly with regard to relevant clinical studies and potential regulatory mechanisms.
This Research Topic aims to present current and novel studies involving the identification of betaine receptors, metabolism, function, and activated signaling pathways in human body, thereby revealing the role of betaine in health, especially its regulatory mechanism, and facilitating the development and utilization of betaine-mediated therapies in human disease.
This Research Topic welcomes original research, systematic and meta-analysis reviews, narrative reviews, and case reports covering the metabolism and alteration of betaine in humans, and its impact on metabolic health and disease. Potential subtopics include but are not limited to the following:
1) Absorption, synthesis, and distribution of betaine in the human body;
2) Betaine alteration and metabolism during disease development;
3) Effect of betaine and its derivatives on tissues/organ development before and after birth;
4) Identification of betaine-mediated receptors and signals in humans, especially using multi-omics;
5) Molecular mechanisms by which betaine modulates health and development in vitro & in vivo.
Keywords:
betaine, health, disease, metabolism, nutrition
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
It is well known that nutritional approaches are widely considered vital ways to maintain health in clinical practice guidelines. Betaine (N,N,N-trimethylglycine) is a non-hazardous naturally occurring nutrient and an amino-acid derivative presenting in many food components. In addition to serving as an important methyl donor for DNA methylation, betaine is also an intermediate in choline metabolism and participates in the regulation of the methionine-homocysteine cycle, one-carbon metabolism, and osmotic pressure. Previous evidence suggests that circulating betaine is significantly correlated with the occurrence of various diseases, including Alzheimer's disease, cardiovascular disease, and cancers, and its supplementation may contribute to the prevention or amelioration of obesity and associated complications. However, the association of betaine with more diseases still needs to be addressed, particularly with regard to relevant clinical studies and potential regulatory mechanisms.
This Research Topic aims to present current and novel studies involving the identification of betaine receptors, metabolism, function, and activated signaling pathways in human body, thereby revealing the role of betaine in health, especially its regulatory mechanism, and facilitating the development and utilization of betaine-mediated therapies in human disease.
This Research Topic welcomes original research, systematic and meta-analysis reviews, narrative reviews, and case reports covering the metabolism and alteration of betaine in humans, and its impact on metabolic health and disease. Potential subtopics include but are not limited to the following:
1) Absorption, synthesis, and distribution of betaine in the human body;
2) Betaine alteration and metabolism during disease development;
3) Effect of betaine and its derivatives on tissues/organ development before and after birth;
4) Identification of betaine-mediated receptors and signals in humans, especially using multi-omics;
5) Molecular mechanisms by which betaine modulates health and development in vitro & in vivo.
Keywords:
betaine, health, disease, metabolism, nutrition
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.