Current Insights in Melanoma Immunology, Immune Escape and Immunotherapy Advances

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Articles

ORIGINAL RESEARCH

Accepted on 01 Aug 2025

Programmed Cell Death-Driven Remodeling of the Melanoma Microenvironment Enables Prognostic Stratification and Therapeutic Prediction Running head: PCD and Immunotherapy in Melanoma

Bo Hu
Xuan Li
Shengnan Chai
Mei Jin
Long Zhang

doi 10.3389/fimmu.2025.1612217

192 views

ORIGINAL RESEARCH

Published on 01 Aug 2025

Baseline metabolic signatures predict clinical outcomes in immunotherapy-treated melanoma patients: a pilot study

Simona De Summa
Giuseppe De Palma
Veronica Ghini
Benedetta Apollonio
Ivana De Risi
Antonio Tufaro
Sabino Strippoli
Claudio Luchinat
Leonardo Tenori
Michele Guida

doi 10.3389/fimmu.2025.1536710

538 views

PERSPECTIVE

Published on 01 Jul 2025

CTLA-4 and PD-1 combined blockade therapy for malignant melanoma brain metastases: mechanisms, challenges, and prospects

Jia-Wen Wang
Ying-Fa Feng
Jia-Hui Liu

doi 10.3389/fimmu.2025.1629879

1,445 views

ORIGINAL RESEARCH

Published on 20 Jun 2025

Overexpression of CTLA-4 and fibronectin, and lower expression of CD137 (4-1BB) is associated with brain metastasis of primary skin melanomas. An analysis of local immune response by digital spatial profiling

Shiva Najjary
Nur al Amery
Mengqi Huang
Disha Vadgama
Alexander C. J. van Akkooi
H. Jacobus Gilhuis
Zineb Belcaid
Dana Mustafa
Johan M. Kros

doi 10.3389/fimmu.2025.1578986

826 views

ORIGINAL RESEARCH

Published on 18 Jun 2025

Identification and validation of a KRAS-macrophage-associated gene signature as prognostic biomarkers and potential therapeutic targets in melanoma

Beichen Cai
Qian Lin
Ruonan Ke
Jiaqi Yu
Lu Chen
Xuejun Ni
Hekun Liu
Xiuying Shan
Biao Wang

doi 10.3389/fimmu.2025.1566432

1,241 views

REVIEW

Published on 08 May 2025

Management of immune-related myocarditis, myositis and myasthenia gravis (MMM) overlap syndrome: a single institution case series and literature review

Alberto Sánchez-Camacho
Alberto Torres-Zurita
Laura Gallego-López
Rocío Hernández-Pacheco
Silvia Silva-Romeiro
María del Carmen Álamo de la Gala
Enrique Peral-Gutiérrez de Ceballos
Luis de la Cruz-Merino

doi 10.3389/fimmu.2025.1597259

3,140 views

ORIGINAL RESEARCH

Published on 08 May 2025

Translating genetics into tissue: inflammatory cytokine-producing TAMs and PD-L1 tumor expression as poor prognosis factors in cutaneous melanoma

Celia Barrio-Alonso
Alicia Nieto-Valle
Lucía Barandalla-Revilla
José Antonio Avilés-Izquierdo
Verónica Parra-Blanco
Paloma Sánchez-Mateos
Rafael Samaniego

doi 10.3389/fimmu.2025.1587545

1,194 views
1 citation

CASE REPORT

Published on 10 Apr 2025

Case Report: Durable remission after abscopal effect following transcatheter hepatic arterial embolization in a patient with mucosal melanoma refractory to immunotherapy

Lynsey M. Claus
Hannah E. Kostan
Marshall E. Hicks
Rony Avritscher
Michael A. Davies

doi 10.3389/fimmu.2025.1565355

1,210 views

ORIGINAL RESEARCH

Published on 03 Apr 2025

Exhaled breath analysis with the use of an electronic nose to predict response to immune checkpoint inhibitors in patients with metastatic melanoma: melaNose trial

Brigit van Dijk
Ivonne J. H. Schoenaker
Astrid A. M. van der Veldt
Jan Willem B. de Groot

doi 10.3389/fimmu.2025.1564463

1,623 views

ORIGINAL RESEARCH

Published on 28 Mar 2025

Transcriptomic signatures in peripheral CD4+T-lymphocytes may reflect melanoma staging and immunotherapy responsiveness prior to ICI initiation

Eleni Palli
Matthieu Lavigne
Panagiotis Verginis
Themis Alissafi
Amalia Anastasopoulou
Georgios Lyrarakis
John M. Kirkwood
Helen Gogas
Dimitrios C. Ziogas

doi 10.3389/fimmu.2025.1529707

2,567 views

ORIGINAL RESEARCH

Published on 16 Dec 2024

Impact of steroid-sparing immunosuppressive agents on tumor outcome in the context of cancer immunotherapy with highlight on melanoma: a systematic literature review and meta-analysis

Jennifer Strouse
Karmela Kimi Chan
Rachel Baccile
Gong He
Diana K. N. Louden
Mihai Giurcanu
Arohi Singh
John Rieth
Noha Abdel-Wahab
3 more
Pankti Reid

doi 10.3389/fimmu.2024.1499478

1,930 views
2 citations

CASE REPORT

Published on 26 Nov 2024

Refractory hypokalemia and metabolic acidosis induced by undifferentiated connective tissue disease secondary to immune checkpoint inhibitors: a case report and literature review

Yinfang Gu
Lilan Yi
Xiaofang Zou
Longhua Guo
Guowu Wu
Jingjing Zhao

doi 10.3389/fonc.2024.1442605

1,169 views
1 citation

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Articles

Programmed Cell Death-Driven Remodeling of the Melanoma Microenvironment Enables Prognostic Stratification and Therapeutic Prediction Running head: PCD and Immunotherapy in Melanoma

Baseline metabolic signatures predict clinical outcomes in immunotherapy-treated melanoma patients: a pilot study

CTLA-4 and PD-1 combined blockade therapy for malignant melanoma brain metastases: mechanisms, challenges, and prospects

Overexpression of CTLA-4 and fibronectin, and lower expression of CD137 (4-1BB) is associated with brain metastasis of primary skin melanomas. An analysis of local immune response by digital spatial profiling

Identification and validation of a KRAS-macrophage-associated gene signature as prognostic biomarkers and potential therapeutic targets in melanoma

Management of immune-related myocarditis, myositis and myasthenia gravis (MMM) overlap syndrome: a single institution case series and literature review

Translating genetics into tissue: inflammatory cytokine-producing TAMs and PD-L1 tumor expression as poor prognosis factors in cutaneous melanoma

Case Report: Durable remission after abscopal effect following transcatheter hepatic arterial embolization in a patient with mucosal melanoma refractory to immunotherapy

Exhaled breath analysis with the use of an electronic nose to predict response to immune checkpoint inhibitors in patients with metastatic melanoma: melaNose trial

Transcriptomic signatures in peripheral CD4+T-lymphocytes may reflect melanoma staging and immunotherapy responsiveness prior to ICI initiation

Impact of steroid-sparing immunosuppressive agents on tumor outcome in the context of cancer immunotherapy with highlight on melanoma: a systematic literature review and meta-analysis

Refractory hypokalemia and metabolic acidosis induced by undifferentiated connective tissue disease secondary to immune checkpoint inhibitors: a case report and literature review

Frontiers in Immunology

Cancer Immunity and Immunotherapy

Participating Journals

Frontiers in Oncology

Cancer Immunity and Immunotherapy