Molecular Pathways and Signaling Molecules in Cancer Therapy: Advances and Innovations

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CASE REPORT

Published on 22 Oct 2025

Case Report: Molecular and immunological insights into primary extramedullary plasmacytoma: discovery of a novel IGH::NFKB1 fusion and its impact on disease progression and treatment

Ziting Gao
Dongbing Li
Tingting Zhang
Wenfeng Su
Jintao Xu
Yuanjie Zhuang
Rong Cao
Yufei Xie
Xingping Lang
4 more
Dan Guo

doi 10.3389/fimmu.2025.1664103

227 views

ORIGINAL RESEARCH

Published on 21 Oct 2025

Hsp70 regulates CD24 expression and promotes metastasis and invasion of lung cancer via the MAPK/ERK signaling pathway

Xin Liu
Xinjing Yu
Qun Hu
Ning Zhang
Shuyu Zhang
Yang Liu
Jiaqi Jia
Xiaojuan Qiao

doi 10.3389/fonc.2025.1665342

285 views

REVIEW

Published on 23 Sep 2025

Research progress on sirtuin family genes in colorectal cancer

Tong Liu
Tianhua Wu
Lijun Luo
Wei Li
Minglin Zhang

doi 10.3389/fonc.2025.1570030

1,923 views

ORIGINAL RESEARCH

Published on 08 Sep 2025

Integrative multi-omics identification and functional validation of potential targets linking metabolism–immune–colorectal cancer causal pathway

Zequn Zheng
Xiaoling Xu

doi 10.3389/fimmu.2025.1649788

1,576 views

ORIGINAL RESEARCH

Published on 04 Sep 2025

Identification and verification of the key genes involved in gallbladder cancer

Jie Tang
Hanxu Zhou
Miao Lu
Dengyi Cao
Yun Zhang
Shaobo Zhou

doi 10.3389/fimmu.2025.1643366

1,123 views

REVIEW

Published on 29 Aug 2025

Leveraging innate immune signals in CD8+ T cells to boost antitumor immunity

Gabriella K. Albert
Phoebe Cao
Eduardo Davila

doi 10.3389/fimmu.2025.1617773

1,497 views

CASE REPORT

Published on 14 Aug 2025

Golidocitinib was used for the first time to treat refractory NK-Large Granular lymphocytic leukemia with a STAT3 mutation, accompanied by hemolytic anemia: a case report

Hongyuan Hao
Chenglu Yuan
Chen Zhang
Jimo Jian

doi 10.3389/fimmu.2025.1632803

1,245 views

REVIEW

Published on 13 Aug 2025

Unravelling molecular mechanism of oral squamous cell carcinoma and genetic landscape: an insight into disease complexity, available therapies, and future considerations

Salima Shebbo
Nooralhuda Alateyah
Esraa Yassin
Doaa El Sayed Mahmoud
Faleh Tamimi
Lamyia Anweigi
Abdelbary Elhissi
Haissam Abou-Saleh
Mohamed A. Elrayess
Abdelali Agouni

doi 10.3389/fimmu.2025.1626243

3,241 views
1 citation

REVIEW

Published on 09 Jun 2025

The activation of cGAS-STING pathway offers novel therapeutic opportunities in cancers

Yumin Wang
Yonglin Zhu
Yuwei Cao
Yulin Li
Zhe Zhang
Joshua S. Fleishman
Sihang Cheng
Jichao Chen
Mingchao Ding

doi 10.3389/fimmu.2025.1579832

3,130 views
6 citations

ORIGINAL RESEARCH

Published on 22 May 2025

CBD promotes antitumor activity by modulating tumor immune microenvironment in HPV associated head and neck squamous cell carcinoma

Prakriti Sen
Sayed Sadat
Koji Ebisumoto
Riyam Al-Msari
Sayuri Miyauchi
Souvick Roy
Pardis Mohammadzadeh
Kristin Lips
Takuya Nakagawa
2 more
Joseph A. Califano

doi 10.3389/fimmu.2025.1528520

4,003 views
1 citation

SYSTEMATIC REVIEW

Published on 23 Jan 2025

Recent trends in research on the role of cholesterol in leukemia: a bibliometric and visualization study

Huijuan Lv
Ke Lu
Ximing Wang
Yanfang Zhang
Mengqi Zhuang
Jing Li
Keli Su
Wen Gao

doi 10.3389/fimmu.2025.1511827

2,352 views
1 citation

ORIGINAL RESEARCH

Published on 12 Dec 2024

Biomarkers of success of anti-PD-(L)1 immunotherapy for non-small cell lung cancer derived from RNA- and whole-exome sequencing: results of a prospective observational study on a cohort of 85 patients

Elena Poddubskaya
Maria Suntsova
Marina Lyadova
Daniil Luppov
Anastasia Guryanova
Vladimir Lyadov
Andrew Garazha
Maksim Sorokin
Anna Semenova
4 more
Anton Buzdin

doi 10.3389/fimmu.2024.1493877

4,074 views
2 citations

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Frontiers in Oncology
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Articles

Case Report: Molecular and immunological insights into primary extramedullary plasmacytoma: discovery of a novel IGH::NFKB1 fusion and its impact on disease progression and treatment

Hsp70 regulates CD24 expression and promotes metastasis and invasion of lung cancer via the MAPK/ERK signaling pathway

Research progress on sirtuin family genes in colorectal cancer

Integrative multi-omics identification and functional validation of potential targets linking metabolism–immune–colorectal cancer causal pathway

Identification and verification of the key genes involved in gallbladder cancer

Leveraging innate immune signals in CD8+ T cells to boost antitumor immunity

Golidocitinib was used for the first time to treat refractory NK-Large Granular lymphocytic leukemia with a STAT3 mutation, accompanied by hemolytic anemia: a case report

Unravelling molecular mechanism of oral squamous cell carcinoma and genetic landscape: an insight into disease complexity, available therapies, and future considerations

The activation of cGAS-STING pathway offers novel therapeutic opportunities in cancers

CBD promotes antitumor activity by modulating tumor immune microenvironment in HPV associated head and neck squamous cell carcinoma

Recent trends in research on the role of cholesterol in leukemia: a bibliometric and visualization study

Biomarkers of success of anti-PD-(L)1 immunotherapy for non-small cell lung cancer derived from RNA- and whole-exome sequencing: results of a prospective observational study on a cohort of 85 patients

Frontiers in Immunology

Cancer Immunity and Immunotherapy

Participating Journals

Frontiers in Oncology

Cancer Immunity and Immunotherapy