Dissecting malaria protective immunity: acquired by natural infection and/or vaccination

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ORIGINAL RESEARCH

Published on 11 Sep 2025

Seroprevalence of antibodies to Plasmodium falciparum transmission-blocking target proteins Pfs230D1M and Pfs48/45 in Tanzanian populations of diverse malaria transmission intensity

Charles Mulamba
Wilmina F. Kalinga
Ivanny Mtaka
Linda O. Lazaro
Janeth Kamage
Irene Nkumama
Olukayode G. Odufuwa
Katharina Kreppel
David Mekhaiel
3 more
Chris Williams

doi 10.3389/fimmu.2025.1589061

1,600 views

ORIGINAL RESEARCH

Published on 14 Jul 2025

Exploring the P. falciparum antigens associated with reduced risk of malaria in pregnancy

Lucy Mwai
Sebastian Musundi
Harrison Waweru
Hikaru Nagaoka
Purity Gacheri Limbua
Takafumi Tsuboi
Eizo Takashima
Jesse Gitaka
Bernard N. Kanoi

doi 10.3389/fimmu.2025.1622435

1,863 views

ORIGINAL RESEARCH

Published on 07 Jul 2025

R21/Matrix-M malaria vaccine drives diverse immune responses in pre-exposed adults: insights from a phase IIb controlled human malaria infection trial

Elizabeth Kibwana
Caroline Bundi
Domtila Kimani
Lydia Nyamako
Kelvias Keter
Agnes Mutiso
Rodney Ogwang
Duncan Bellamy
Katerina Rapi
12 more
Melissa Kapulu

doi 10.3389/fimmu.2025.1620365

2,556 views

ORIGINAL RESEARCH

Published on 02 Jul 2025

Development of high affinity antibodies to Plasmodium falciparum merozoite and sporozoite antigens during infancy and adulthood

Allan Lugaajju
Richard Idro
Stephen Kiwuwa
James G. Beeson
Damien R. Drew
Susanne E. Mortazavi
Sara Linse
Kristina E. M. Persson

doi 10.3389/fimmu.2025.1562671

1,690 views

ORIGINAL RESEARCH

Published on 26 Jun 2025

Vaccine-induced responses to R21/Matrix-M – an analysis of samples from a phase 1b age de-escalation, dose-escalation trial

Caroline Bundi
Duncan Bellamy
Elizabeth Kibwana
Lydia Nyamako
Rodney Ogwang
Kelvias Keter
Domtila Kimani
Ahmed M. Salman
Samuel Provstgaard-Morys
6 more
Melissa C. Kapulu

doi 10.3389/fimmu.2025.1620366

2,306 views

ORIGINAL RESEARCH

Published on 26 Feb 2025

Antibody responses in Burkinabe children against P. falciparum proteins associated with reduced risk of clinical malaria

Takaaki Yuguchi
Benedicta O. Dankyi
Rattanaporn Rojrung
Hikaru Nagaoka
Bernard N. Kanoi
Alfred B. Tiono
Issa Nebie
Alphonse Ouedraogo
Kazutoyo Miura
3 more
Eizo Takashima

doi 10.3389/fimmu.2025.1521082

1,853 views

ORIGINAL RESEARCH

Published on 11 Feb 2025

Placental malaria infection is associated with downregulation of STAT-6 and ANG-1 in decidual macrophages

Fred Owino
Caroline Kijogi
Omu Anzala
Edwin Walong
Obiero Jael
Steven G. Nyanjom
Agola Lelo Eric
Bernard N. Kanoi
Jesse Gitaka

doi 10.3389/fimmu.2025.1497936

2,510 views
1 citation

ORIGINAL RESEARCH

Published on 09 Dec 2024

Naturally acquired IgG responses to Plasmodium falciparum do not target the conserved termini of the malaria vaccine candidate Merozoite Surface Protein 2

Julia Zerebinski
Lucille Margerie
Nan Sophia Han
Maximilian Moll
Matias Ritvos
Peter Jahnmatz
Niklas Ahlborg
Billy Ngasala
Ingegerd Rooth
4 more
David Fernando Plaza

doi 10.3389/fimmu.2024.1501700

2,181 views
1 citation

ORIGINAL RESEARCH

Published on 18 Nov 2024

Estimation of PfRh5-based vaccine efficacy in asymptomatic Plasmodium falciparum patients from high-endemic areas of Tanzania using genetic and antigenicity variation screening

Hojong Jun
Ernest Mazigo
Wang-Jong Lee
Johnsy Mary Louis
Jadidan Hada Syahada
Fadhila Fitriana
Jin Heo
Yeonkyung Kim
Boeun Kwon
15 more
Jin-Hee Han

doi 10.3389/fimmu.2024.1495513

2,578 views
4 citations

ORIGINAL RESEARCH

Published on 01 Nov 2024

ProC6C, a novel multi-stage malaria vaccine, elicits functional antibodies against the minor and central repeats of the Circumsporozoite Protein in human adults

Jordan Plieskatt
Ebenezer Addo Ofori
Mohammad Naghizadeh
Kazutoyo Miura
Yevel Flores-Garcia
Nis Borbye-Lorenzen
Alfred B. Tiono
Kristin Skogstrand
Issaka Sagara
1 more
Michael Theisen

doi 10.3389/fimmu.2024.1481829

2,906 views
6 citations

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Parasite Immunology

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Articles

Seroprevalence of antibodies to Plasmodium falciparum transmission-blocking target proteins Pfs230D1M and Pfs48/45 in Tanzanian populations of diverse malaria transmission intensity

Exploring the P. falciparum antigens associated with reduced risk of malaria in pregnancy

R21/Matrix-M malaria vaccine drives diverse immune responses in pre-exposed adults: insights from a phase IIb controlled human malaria infection trial

Development of high affinity antibodies to Plasmodium falciparum merozoite and sporozoite antigens during infancy and adulthood

Vaccine-induced responses to R21/Matrix-M – an analysis of samples from a phase 1b age de-escalation, dose-escalation trial

Antibody responses in Burkinabe children against P. falciparum proteins associated with reduced risk of clinical malaria

Placental malaria infection is associated with downregulation of STAT-6 and ANG-1 in decidual macrophages

Naturally acquired IgG responses to Plasmodium falciparum do not target the conserved termini of the malaria vaccine candidate Merozoite Surface Protein 2

Estimation of PfRh5-based vaccine efficacy in asymptomatic Plasmodium falciparum patients from high-endemic areas of Tanzania using genetic and antigenicity variation screening

ProC6C, a novel multi-stage malaria vaccine, elicits functional antibodies against the minor and central repeats of the Circumsporozoite Protein in human adults

Frontiers in Immunology

Parasite Immunology