About this Research Topic
Polyphenols are compounds that have phenolic structural characteristics and contain multiple hydroxyl groups. Humans obtain them primarily from cereals, fruits, vegetables, and beverages. More than 8,000 polyphenolic structures have been identified to date. Polyphenols can be absorbed mainly through the small intestine. Besides, they are metabolized in the intestine and liver. Many others are not readily absorbed and reach the large intestine, being metabolized by the bacteria colonizing this organ, considerably altering their chemical structures, although it is unknown whether de novo synthesized polyphenols can be absorbed by the colon.
Despite a marked decline in the prevalence of communicable diseases, the leading causes of illness worldwide today are non-communicable diseases (NCDs), including cancers, cardiovascular diseases, metabolic syndrome, cognitive decline, and age-related macular degeneration. Inflammation appears to be a key component in each of these disorders. Various other factors, including oxidative stress, endothelial dysfunction, sympathetic nervous system dysfunction, increased platelet aggregability, insulin resistance, environmental factors, lifestyle choices, genetics, and epigenetics, all play a role in the development of NCDs.
An unhealthy lifestyle, which includes an inadequate diet, insufficient sleep, physical inactivity, psychological stress, environmental pollution, smoking, or alcohol addiction, all contribute to metabolic changes that can lead to the development of NCDs.
In this context, a healthy lifestyle and eating habits may provide protective effects, improving life expectancy. Nutrition plays a significant role in NCDs prevention. Indeed, recognizing dietary polyphenols as anti-inflammatory modulators provides scope for their use in managing NCDs. Due to their role as redox modulators and ability to inhibit the NF-κB signaling pathways, they have an intimate relationship with inflammation. Innovative prospects for treating and controlling NCDs have arisen due to our growing understanding of inflammation and the molecular mechanisms linking polyphenols with immune responses.
This special issue welcomes mesarch and review contributions from academics and researchers worldwide on their most recent scientific discoveries and developments in the area where polyphenols, inflammation, and inflammation-associated NCDs converge. We encourage papers that encompass a wide range of subjects, encompassing issues such as (but not limited to):
- Cardiovascular diseases;
- Metabolic syndrome;
- Cancers ;
- Gut microbiota modulation
- Signaling pathways;
- Clinical trials
- In vivo-based evidence;
- In vitro-based findings;
- In silico-based outcomes.
Despite a marked decline in the prevalence of communicable diseases, the leading causes of illness worldwide today are non-communicable diseases (NCDs), including cancers, cardiovascular diseases, metabolic syndrome, cognitive decline, and age-related macular degeneration. Inflammation appears to be a key component in each of these disorders. Various other factors, including oxidative stress, endothelial dysfunction, sympathetic nervous system dysfunction, increased platelet aggregability, insulin resistance, environmental factors, lifestyle choices, genetics, and epigenetics, all play a role in the development of NCDs.
An unhealthy lifestyle, which includes an inadequate diet, insufficient sleep, physical inactivity, psychological stress, environmental pollution, smoking, or alcohol addiction, all contribute to metabolic changes that can lead to the development of NCDs.
In this context, a healthy lifestyle and eating habits may provide protective effects, improving life expectancy. Nutrition plays a significant role in NCDs prevention. Indeed, recognizing dietary polyphenols as anti-inflammatory modulators provides scope for their use in managing NCDs. Due to their role as redox modulators and ability to inhibit the NF-κB signaling pathways, they have an intimate relationship with inflammation. Innovative prospects for treating and controlling NCDs have arisen due to our growing understanding of inflammation and the molecular mechanisms linking polyphenols with immune responses.
This special issue welcomes mesarch and review contributions from academics and researchers worldwide on their most recent scientific discoveries and developments in the area where polyphenols, inflammation, and inflammation-associated NCDs converge. We encourage papers that encompass a wide range of subjects, encompassing issues such as (but not limited to):
- Cardiovascular diseases;
- Metabolic syndrome;
- Cancers ;
- Gut microbiota modulation
- Signaling pathways;
- Clinical trials
- In vivo-based evidence;
- In vitro-based findings;
- In silico-based outcomes.
Keywords: Diet, polyphenols, inflammation, diabetes, obesity, insulin resistance, cancers, signaling pathways
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