Application of New Approach Methodologies in Toxicological Assessment of Next Generation Tobacco and Nicotine Products

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ORIGINAL RESEARCH

Published on 15 May 2025

Quantitative adverse outcome pathway modeling for cigarette smoke-inducible airway mucus hypersecretion. Part 2: Bayesian network modeling for probabilistic risk estimation

Shigeaki Ito
Sakuya Ichikawa
Risa Matsumoto
Shugo Muratani
Keigo Sano
Akina Mori
Kazuo Erami

doi 10.3389/ftox.2025.1564864

938 views

ORIGINAL RESEARCH

Published on 15 May 2025

Quantitative adverse outcome pathway modeling for cigarette-smoke-induced airway mucus hypersecretion. Part 1: adverse-outcome-pathway-based in vitro assessment with repeated exposure to whole cigarette smoke

Sakuya Ichikawa
Shugo Muratani
Keigo Sano
Kazuo Erami
Akina Mori
Risa Matsumoto
Shigeaki Ito

doi 10.3389/ftox.2025.1564857

1,072 views

ORIGINAL RESEARCH

Published on 13 Jun 2024

Optimisation of an in vitro human cardiovascular model on-a-chip for toxicological assessment of nicotine delivery products

Fiona Chapman
Luuk de Haan
Linda Gijzen
Wouter Strijker
Edgar Trelles Sticken
Sarah Jean Pour
Roman Wieczorek
Florian Haberstroh
Sandra Otte
2 more
Matthew Stevenson

doi 10.3389/ftox.2024.1395670

3,857 views
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Frontiers in Toxicology

Frontiers in Toxicology

Regulatory Toxicology
Computational Toxicology and Informatics
In Vitro Toxicology
Immunotoxicology

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