New Approach Methodologies for the assessment of Cardiovascular Diseases and Drug Induced Cardiotoxicity

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ORIGINAL RESEARCH

Accepted on 30 Jul 2025

Integral approach to organelle profiling in human iPSCderived cardiomyocytes enhances in-vitro cardiac safety classification of known cardiotoxic compounds

Brigitta Rita Szabo
Jeroen Stein
Anna Savchenko
Thomas Hutschalik
Filip Van Nieuwerburgh
Tim Meese
Georgios Kosmidis
Paul G A Volders
Elena Matsa

doi 10.3389/ftox.2025.1644119

REVIEW

Published on 30 Jun 2025

An adverse outcome pathway for cigarette smoke-mediated oxidative stress in plaque formation

Patrudu Makena
Linsey E. Haswell
Michael McEwan
Brian M. Keyser
David E. Smart
Robert Leverette
Kristen Jordan
Damien Breheny
Sarah Baxter-Wright

doi 10.3389/ftox.2025.1554747

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Frontiers in Toxicology

Frontiers in Toxicology

In Vitro Toxicology

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