Gut Microbiome and its Attribution with Cardio-Metabolic Diseases: from Dysbiosis to Therapeutic Strategies

The interaction between the gut microbiome and cardio-metabolic diseases forms a burgeoning field in health research. The human gastrointestinal tract hosts a complex microbial community that plays critical roles in metabolism, signalling, and immune modulation. Historically, a balanced gut microbiome conferred protection against diseases via colonization resistance. However, factors such as industrialization —characterized by urbanization, changes in dietary patterns, and increased of antibiotic misuse— have diminished microbiome diversity, correlating with an uptick in cardio-metabolic diseases like obesity, type 2 diabetes, and cardiovascular conditions. Recent studies have illuminated significant links between gut microbiome composition and both in the onset and mitigation of these diseases. Yet, a comprehensive understanding of these relationships remains elusive, underscoring the need for further exploration to inform potential therapeutic interventions.

This Research Topic aims to delineate the intricate associations between the gut microbiome and cardio-metabolic diseases. The goals include identifying specific microbial profiles implicated in these diseases, elucidating how gut microbiota influence disease risk and protection, and assessing their potential as novel treatment or prevention modalities. By unravelling these complex interrelations, the research may pave the way for innovative therapeutic strategies to effectively manage or prevent cardio-metabolic disorders.

To gather further insights into the gut microbiome's role in cardio-metabolic diseases, we welcome articles addressing, but not limited to, the following themes:

o Specific gut microbiota changes linked to the development of cardio-metabolic diseases and the underlying mechanisms influencing disease risk and severity.
o Molecular and cellular pathways through which gut microbiota affect cardio-metabolic disease susceptibility, touching on chronic inflammation and immune modulation.
o Identification of nutritional and bioactive compounds produced by gut microbiota with protective effects against cardio-metabolic diseases.
o Evolution of conventional treatments when combined with microbiome-targeted therapies for enhanced outcomes.
o Influences of diet and lifestyle on gut microbiome health and implications for managing cardio-metabolic diseases.

We invite submissions of original research articles, reviews, and mini-reviews to foster a multidisciplinary dialogue and drive pioneering advancements towards improved clinical outcomes in cardio-metabolic health.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Community Case Study
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Community Case Study
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Policy Brief
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: gut microbiome, cardio-metabolic diseases, Dysbiosis, Metabolic Syndrome, Microbiota-host Interactions, Cardiac Function, Microbiome Diversity, Bacterial Metabolites

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.