Dietary Antioxidants and their Impact on Oxidative Stress and Cancer Prevention

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About this Research Topic

Submission deadlines

  1. Manuscript Summary Submission Deadline 6 August 2025 | Manuscript Submission Deadline 24 November 2025

  2. This Research Topic is still accepting articles.

Background

Cancer research has gained intense focus in recent decades due to its significant impact on global mortality rates, with approximately 10 million deaths in the year 2020. Oxidative stress has been widely recognized as a critical contributor to cancer pathogenesis, with reactive oxygen species (ROS) facilitating the progression of various cancer types. While a substantial proportion of cancers may be influenced by lifestyle and dietary factors, the potential role of diets rich in antioxidants to modulate oxidative stress presents an area of considerable interest. Antioxidants have the potential to counteract ROS-induced cellular damage by shielding essential biomolecules such as DNA, proteins, and lipids. Numerous studies highlight the potential of natural products, which are rich in diverse phytochemicals, in mitigating oxidative stress and enhancing immune function. However, the intricate interactions between dietary antioxidants and the human redox system, influenced by genetic and acquired defects in enzymes involved in redox signaling pathways require further investigation.

This Research Topic aims to provide a platform for researchers to publish the recent research and advancements in the biochemical evaluation of diets and foods rich in antioxidants within the scope of human nutrition and cancer biology. We cordially invite researchers to contribute original research or review articles that elucidate the molecular mechanisms by which antioxidants interact with cancer biology and oxidative stress. Potential contributions can include studies on bioactivity and bioavailability, mechanisms of action of antioxidant molecules within cancer contexts, and insights into how these antioxidants modulate inflammation and oxidative stress.

To gather further insights into how dietary antioxidants interact within cancer contexts, we welcome articles addressing, but not limited to the following themes:

• Anticancer activity and bioavailability studies on plant-derived polyphenols
• Mechanism of action of dietary antioxidants related to cancer contexts
• Elucidation of dietary antioxidants on the molecular mechanisms involved in inflammation and redox modulation
• Human, in vivo, and in vitro studies of dietary antioxidants and their role in cancer contexts
• Design of novel functional foods and their derived bioactive compounds in relation to cancer
• Interaction between antioxidants and oxidative stress in cancer contexts
• The proteomic and genomic approach of dietary antioxidants in relation to human nutrition and cancer biology

We seek original research, review articles, and other contributions that will expand our understanding of the role of dietary antioxidants in human nutrition that relate to cancer contexts.

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Keywords: Ascorbic acid;Cancer;Carotenoid;Dietary Antioxidant;Metastasis;Organosulfur compounds;Oxidative stress;Polyphenol;Ubiquinone; Vitamin E cancer, oxidative stress, ROS, antioxidants, dietary antioxidants, phytochemicals, polyphenols, nutrition, inflammation

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