This Research Topic is part of a series with:
Neurobehavioral Toxicity induced by Environmental Contaminants: Mechanisms of Neurodegeneration and Neuroprotection, Volume IThe development of societies and advances in technologies that bring comfort to modern life has resulted in the discharge of a diversity of compounds into the environment. Among these compounds, to which we are daily exposed, many can impact the nervous system of both adults and children, affecting both neurodevelopment during organogenesis. These toxic effects can result in neurobehavioral changes or induce neurodegenerative diseases. Within this context, reactive oxygen species (ROS) induced by mitochondrial dysfunction have an important role considering that oxidative stress can lead to the oxidation of macromolecules such as lipids, proteins, and nucleic acid. This effect is critical for the central and peripheral nervous system due to a large amount of these macromolecules, especially lipids.
In this Research Topic, we welcome especially Original Research articles reporting on any aspect of chemical-induced neurotoxicity, as well as mechanisms of neuroprotection. The development of new methods or protocols to evaluate neurotoxicity utilizing in vivo, in vitro or ex vivo model systems, especially using alternative methods and protocols are also welcome.
Potential topics include, but are not limited to:
- In vivo, in vitro, in silico methods for the evaluation of environmental pollutant-induced neurotoxicity.
- Neurobehavioural assessment using Zebrafish model.
- Invertebrate models used for the evaluation of neurotoxic effects induced by environmental compounds.
- Mechanism of neuroprotection and neuroprevention.
- Relation of mitochondrial disorder with neurotoxicity/neurodiseases.
- ROS generation and oxidative stress related to neurodegeneration.
- Calcium role on neurodiseases.
- Mode of action of environmental contaminants.
- Evidence of human neurotoxicity induced by environmental neurotoxicants.
- Impacts of environmental contaminants exposure on the neurodevelopment.
