Regulation of Metabolic Rewiring in T-Cell Malignancies

T-cell malignancy is a rare neoplastic disorder. The clinical management of T-cell malignancies is highly complex and complicated due to their crucial involvement in antitumor immunity. Interestingly, in recent years, studies have shown a vital role of aberrant metabolism in the unhindered development and progression of T-cell malignancies. However, the pathways involved in the regulation of altered metabolism of malignant T-cells are poorly understood. There is an urgent need to decipher those pathways for designing novel targeted therapeutic strategies against malignancies of T-cells. Various research groups are continuously working in this direction to identify mechanistic pathways, crucial transcriptional and translational regulators, and metabolic regulatory molecules for developing novel diagnostic tools and promising therapeutic candidates against malignancies of T-cells.

The aim of the proposed research topic is to provide in-depth information about the regulatory action of various biomolecules including, hormones, cytokines, bioactive lipids and miRNAs etc in the metabolic reprogramming in T lymphoma cells on a single platform. The one place collection of articles on metabolic adjustments in T-cell neoplasms, their regulation, and therapeutic targeting will be of colossal advantage. This topic will include studies exploring the mechanistic involvement of molecular and bio-physiological elements in cross-regulation with metabolic phenotypes. Hence, the proposed research topic will help in understanding the metabolic nature of T-cell malignancies by providing novel insights into the mechanistic pathways involved in the metabolic rewiring of T-cell malignancies and will also shed light on the diagnostic and therapeutic potential of various metabolic regulatory molecules.

The research topic is primarily focused on the following themes:
1. Regulation of altered metabolism of malignant T cells by bioactive lipids
2. Hormonal regulation of T lymphoma cell metabolism
3. Role of miRNAs in reprogramming of metabolism of malignant T cells
4. Alteration in the metabolism of malignant T cells by cytokines
5. Identification of novel signaling pathways and molecules involved in dysregulated metabolism of T lymphoma cells
6. Antimetabolic activity of various synthetic and natural compounds against T cell malignancies

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.