New Strategies for Reversing Cancer Therapy Resistance

To overcome the challenge, identifying the drug resistance-associated genes is important. Zhang et al. reviewed a genome-wide CRISPR/Cas9 screening method for identifying potential drug resistanceassociated genes (Zhang et al. 2023. Genome-wide CRISPR/Cas9 screening for drug resistance in tumors). This screening approach holds substantial promise for advancing the treatment of malignancies that have developed drug resistance. This article provides an overview of drug resistance pathways such as the KEAP1/Nrf2 pathway, MAPK pathway, NF-κB pathway, etc.In addition to the gene mutation, numerous studies have discovered the close relationship between lipid metabolism and cancer drug resistance. Wang et al. reviewed the alterations in lipid metabolism associated with drug resistance and elucidate how lipid metabolism influences this resistance (Wang et al. Lipid metabolism as a target for cancer drug resistance: progress and prospects). It has been indicated that combination therapy could induce changes in lipid-related metabolic pathways, potentially reversing the progression of cancer drug resistance and augmenting or restoring sensitivity to therapeutic drugs. Thus, this review explores the intersection of medication combination with lipid metabolism and drug resistance, offering novel insights and strategies for future tumor treatment.