Amazing anticancer therapy advancements have been made in the last decade due to tremendous innovations. Nonetheless, drug resistance remains a major challenge that limits the effectiveness of anticancer therapies, causing cancer recurrence and metastasis and being a major cause of cancer-related death. Drug resistance can be caused by complex molecular mechanisms such as gene mutations, epigenetic dysregulation, microenvironment alterations, etc. Many clinical strategies, including combination therapies and epigenetic drugs, have been used to avoid or reverse drug resistance effectively. However, the progression of cancers (in patients under treatment) or the lack of response of cancer patients indicate that current approaches to overcome resistance are far from sufficient, and more work is needed.
This collection encourages high-quality research contributions to the understanding of the underlying mechanisms of resistance and the identification of new targets to reverse drug resistance in cancers.
We welcome original research, clinical trials and reviews. The research topics include but are not limited to:
• Investigating new tumor resistance mechanisms
• New strategies to overcome resistance (reshaping the tumor microenvironment, epigenetic regulation, targeting cancer stem cell pathways, etc.).
• Novel anti-cancer drugs to combat resistance (nanomedicine, siRNA drugs, aptamer-mediated drug delivery systems, bispecific antibodies, etc.).
• Combination of anticancer therapies to reverse anticancer drug resistance.
• Cancer therapy resistance biomarkers.
Amazing anticancer therapy advancements have been made in the last decade due to tremendous innovations. Nonetheless, drug resistance remains a major challenge that limits the effectiveness of anticancer therapies, causing cancer recurrence and metastasis and being a major cause of cancer-related death. Drug resistance can be caused by complex molecular mechanisms such as gene mutations, epigenetic dysregulation, microenvironment alterations, etc. Many clinical strategies, including combination therapies and epigenetic drugs, have been used to avoid or reverse drug resistance effectively. However, the progression of cancers (in patients under treatment) or the lack of response of cancer patients indicate that current approaches to overcome resistance are far from sufficient, and more work is needed.
This collection encourages high-quality research contributions to the understanding of the underlying mechanisms of resistance and the identification of new targets to reverse drug resistance in cancers.
We welcome original research, clinical trials and reviews. The research topics include but are not limited to:
• Investigating new tumor resistance mechanisms
• New strategies to overcome resistance (reshaping the tumor microenvironment, epigenetic regulation, targeting cancer stem cell pathways, etc.).
• Novel anti-cancer drugs to combat resistance (nanomedicine, siRNA drugs, aptamer-mediated drug delivery systems, bispecific antibodies, etc.).
• Combination of anticancer therapies to reverse anticancer drug resistance.
• Cancer therapy resistance biomarkers.
