Green Protocols in Heterocycle Syntheses via 1,3-Dipolar Cycloadditions

Introduction

The design of efficient and sustainable synthetic protocols is of primary importance to green pharmaceutical chemistry. The selection of suitable starting materials, methodologies with good atomic balance, a minimum number of steps and green solvents will allow this beneficial goal to be achieved. Heterocyclic chemistry plays a key role in drug production and the application of efficient green synthetic processes has a significant impact on pharmaceutical industries. There are a number of successful examples of benign synthetic protocol, including the use of non-conventional technologies such as microwave of ultrasound irradiations (Garella et al., 2013) and the use of water or green organic solvents (Moulay and Touati, 2010; Butler and Coyne, 2016). In the last decade, in this area, green chemistry and click chemistry have respected a pathway of rigorous principles, by means of which more efficient and greener processes can be defined (Anastas and Eghbali, 2010). Since the capital discovery by the teams of Meldal (Tornøe et al., 2002) and Sharpless (Rostovtsev et al., 2002), copper-catalyzed azide-alkyne cycloaddition (CuAAC) provides regioselectivity under mild conditions substituted triazole. Based on its large applicability, several research areas have taken advantage of its peculiar benefits and this reaction can be considered the click reaction par antonomasia. More in general, 1,3-dipolar cycloadditions are six π-electrons, concerted reactions that have a wide range of applications in organic synthesis and, specifically, in the preparation of five membered heterocyclic rings. Their good atomic balance and their synthetic potential resulted maximized when 5 terms heterocycles are obtained in sustainable solvents with high stereo or enantioselectivity.

Many authors still use the terms “[2+3] or [3+2] cycloaddition,” which count the number of involved atoms, but do not follow IUPAC recommendations. In this paper, we follow the IUPAC requirements, meaning that all reactions are referred to in accordance with the following rules:

• A (i + j +…) cycloaddition is a reaction in which two or more molecules (or parts of the same molecule), provide units of i, j, in which i and j stand for linearly connected atoms. In the final product, these units become joined by new σ-bonds so as to form a cycle containing (i + j +…) atoms.

• The terminology [i + j +…] for a cycloaddition identifies the numbers, i and j, of π electrons in the interacting units that participate in the transformation of reactants to products (see http://goldbook.iupac.org/html/C/C01496.html).

The aim of this review is to provide an overview of green protocols for the organic synthesis of heterocycles via 1,3-dipolar cycloaddition. The azides-alkynes cycloadditions, well-known as Huisgen reactions, will not be taken into detailed account because of their large presence in literature, both in original publication and in review. In the present review particular attention has been devoted to the use of green solvents; reactions performed in ionic liquids, fluorinated solvents and water have been included. Also explored are several protocols that make use of catalyst-free reaction conditions, the use of microwave irradiation and activation by light exposure. Improvements over commonly used organic solvents will be underlined in order to highlight environmental protection aspects and enhancements in regio- and stereoselectivity.

1,3-Dipolar Cycloaddition in Ionic Liquids

The elimination of the use of volatile organic solvents and their replacement by non-inflammable, non-volatile, non-toxic, and inexpensive green solvents is an important aspect of green chemistry. Their unique properties, including high chemical and thermal stability, solvating ability, ability to behave as both acidic and basic catalysts and recyclability, have led to ionic liquids gaining widespread recognition as green solvents that are advantageous to use in organic synthesis. Their manifold use in this context has therefore emerged as a formidable ally for green chemistry. Besides the catalyzing ability of ionic liquids, their solubility, viscosity, density, acidic, or basic character and refractive index, can be tuned by judiciously modifying the anion/cation combinations. This means that for multicomponent reactions and 1,3-dipolar cycloadditions, they might be the reaction media of choice.

In 2007, 1,3-dipolar azomethine ylide cycloaddition has been studied in ionic liquid and the authors observed that pyrrolizidines can be obtained in high yield at 50°C in ionic liquid 1-butyl-3-methylimidazolium [bmim][BF₄] in 10–40 min, while under conventional conditions in boiling acetonitrile it requested 90–300 min (Jadidi et al., 2007). Kathiravan and Raghunathan (2013) studied an intramolecular 1,3-dipolar in [bmim][BF₄] as the medium and pyrrolo[2,3-a]pyrrolizidino derivatives were obtained, as described in Scheme 1. Starting from pyrrole-2-carbaldehyde and allyl bromide, the authors obtained N-alkenyl pyrrole-2-carbaldehyde that converted in presence of sarcosine in pyrrolo[2,3-a]pyrrolidines, pyrrolizidines, indolizidines, and isoquinolines. The reaction was performed at 85°C and in 3 h, and pyrrolopyridines were obtained in good yields (80–92%) from the 1,3-dipolar cycloaddition reactions. To provide an optimization of the method the authors also carried out the reaction in different organic solvents, including methanol, toluene, and acetonitrile. The reaction was slower and afforded lower yields of the desired products when performed in the organic solvents compared to ionic liquid.

SCHEME 1

Scheme 1. Synthesis of N-methylpyrrol[2,3-a]pyrrolizidine.

A three component 1,3-dipolar cycloaddition, one pot reaction has been described (Almansour et al., 2015) to obtain dispirooxindolopyrrolidines. In situ generated azomethine ylides from L-phenylalanine and substituted isatins were used in equimolar ratio with a series of (E)-2-oxoindolino-3-ylidene acetophenone in [bmim][BF₄] to furnish the cycloadducts in 70–77% yield and high regioselectivity (Scheme 2). When compared with organic solvent such as methanol, ethanol, dioxane, and a dioxane/methanol (1:1) mixture under heating in an oil-bath, they gave the desired product in lower yield (28–38%) with low selectivity. The same reaction was investigated in ionic liquids using catalyst in 10 mol%, [bmim][BF₄]/CuI, [bmim][BF₄]/Zn(OTf)₂. These reactions furnished both regioisomers A and B, but good yield and high selectivity were observed toward the product A. The ionic liquids [bmim]BF₄ and [bmim]Br were found to be the most suitable reaction media and as described by the authors in the proposed mechanism (Scheme 3), ionic liquids play the dual role of solvent and catalyst and an increase in reaction rate is observed when compared to other organic solvents.

SCHEME 2

Scheme 2. Synthesis of dispirooxindolopyrrolidines.

SCHEME 3

Scheme 3. Possible mechanism of the synthesis of dispirooxindolopyrrolidine regioisomers.

Another example of one pot three components reactions was published in 2015 by the same authors (Arumugam et al., 2015) that described a general and efficient path for the regio- and stereo-selective synthesis of dispirooxindole-fused anthrones. The reaction was a reaction pathway (Scheme 4) started from acid-catalyzed condensation of anthracen-9(10H)-one in presence of benzaldehydes to obtain 10-benzylideneanthracen-9(10H)-ones that was submitted to 1,3-dipolar cycloaddition with non-stabilized azomethine ylide from sarcosine and isatin (in situ generated). When performed in ethanol, methanol, dioxane, and a dioxane/methanol (1:1 v/v) at reflux, the 1,3-dipolar cycloaddition failed. The desired product was obtained in 65% yield in 3 h in DMF at reflux. Working in the presence of [bmim]Br at 100°C, the product was obtained in high yield (89%) and the reaction rate increased compared to DMF. Moreover, the ionic liquid was recovered and reused. The reaction was proved as regioselective. The reaction showed high tolerance toward substituted benzaldehyde and electron donating as well as electron-withdrawing substituents at ortho, meta, and para positions gave satisfactory yields. ¹H-,¹³C-, and 2D-NMR spectroscopy was exploited to elucidate the stereochemistry of the final product and unambiguously the stereochemistry was confirmed using a single crystal X-Ray diffraction study.

SCHEME 4

Scheme 4. Synthesis of 9-arylmethylene-10-anthrone and following 1,3-dipolar cycloaddition to bis-spiro compound.

Also Jain et al. (2012) reported the enhancement in yield and rate due to the use of ionic liquid in 1,3-dipolar cycloaddition reaction via the generation of azomethine ylides from isatin and sarcosine (Scheme 5) to synthesize dispiropyrrolidine-bisoxindole. The dipolarophile employed was the olefin obtained by Knoevenagel condensation of isatin and un/substituted acetophenones and 2-acetylthiophene. In presence of [bmim]PF₆, the azomethine ylides approached the dipolarophiles regioselectively and excellent yields in short reaction times were obtained. Furthermore, there was no need for further purification processes, such as column chromatography, and the products were characterized by spectroscopic and analytical studies.

SCHEME 5

Scheme 5. Synthesis of dispiropyrrolidine derivatives.

The stereoselectivity of the 1,3-dipolar cycloaddition is governed by both the orientation at which the dipole and dipolarophile approached and the conformation of the ylide. In the mentioned study, the authors hypothesize that constraints dictate that only one specific isomer can be involved in the transition state of the cycloaddition reaction. As described in the Scheme 6, the reaction occurs through one of the ylide geometries therefore its addition to dipolarophiles takes place under the control of relative stereochemistry at the spiro center. The formation of sterically hindered ylide was not obtained owing to steric repulsion between the oxindole carbonyl group and the methyl group of sarcosine. Ionic liquid recyclability was proved by the authors.

SCHEME 6

Scheme 6. Schematic representation of plausible secondary orbital interaction of azomethine ylide.

The parallel synthesis of novel molecular frameworks has been greatly enhanced by the discovery of the synergy between microwave irradiation and ionic liquid. Being a heterocycle of immense importance because of its potential biological activity, 1,3-dipolar cycloaddition under MW irradiation in ionic liquid has been explored for facilitating accelerations in drug discovery. Kumar et al. (2015) have studied the molecular recognition of cage compounds and attempted the incorporation into their structure or a second cavity that can participate in structure recognition. 1,3- dipolar cycloaddition between N-unsubstituted 3,5-bis[(E)-arylmethylidene]tetrahydro- 4(1H)-pyridinones and azomethine ylides was exploited for the synthesis of novel diazahexa- and diazaheptacyclic ring. Azomethine ylides were generated in situ from acenaphthenequinone and α-amino acids (initially, proline and then phenylglycine). Initially the authors performed the reaction under conventional conditions and methanol, ethanol, ethanol−1,4-dioxane mixture (1:1 v/v), and 1,4-dioxane were employed in refluxing to afford the heptacyclic cage structure in 72, 60, 70, and 69% yields, respectively. When the reaction was performed in [bmim]Br at 100°C, the desired product was recovered in 81% yield in 20 min. The synergic effected of MW irradiation and ionic liquid was proved when an equimolar mixture of the starting materials in [bmim]Br was subjected to MW irradiation at 100°C for 4 min. The cage compound was recovered in 85% yield after purification by extraction and crystallization. The ionic liquid [bmim]Br was dried under reduced pressure after product extraction and its recyclability was investigated in successive syntheses of the cage compound, revealing that its efficacy was not particularly reduced in the three subsequent runs (Scheme 7).

SCHEME 7

Scheme 7. Synthetic route of diazapoycyclic cage compounds.

Recently guanidine ionic liquids (GILs) have also emerged and have been efficiently used, as new-generation ionic liquids, in several reactions (Henry reaction, aldol reaction, Heck reaction etc.). The preparation of novel dispiropyrrolidine derivatives under green conditions was studied by Dandia et al. (2012) exploiting the task-specific ionic liquid 1,1,3,3-tetramethylguanidine acetate [TMG][Ac] as the reusable solvent in a 1,3-dipolar cycloaddition. The reaction was carried out in the presence of an equimolar mixture of sarcosine, ninhydrin, and 1-benzyl/methyl-3,5-bis[(E)-arylidene]-piperidin-4-one and at 80°C in 1,1,3,3- tetramethylguanidine acetate [TMG][Ac] for 3–6 h and the desired products were in good yields (86–92%). When different solvents were compared, the authors employed ethanol, methanol, dioxane, acetonitrile, and toluene, as well as several ionic liquids, including [bmim] BF₄ and [bmim]Cl. All these solvents were found to give comparatively low product yields (42–82% yield compared to 86–89 of ionic liquids in more than 5 h) and [TMG][Ac] was the best solvent, giving higher yields and shorter reaction times (92% yield in 3 h). A single regioisomer was isolated in all cases (Scheme 8).

SCHEME 8

Scheme 8. Synthesis of dispiropyrrolidine derivatives.

1,3-Dipolar Cycloaddition in Fluorinated Solvents

2,2,2-trifluoroethanol is considered an ideal solvent and co-solvent because of its high ionizing power and strong hydrogen bond-donating ability, which provide good catalytic potential in a variety of organic transformations.

The use of 2,2,2-trifluoroethanol as a recoverable greener solvent was explored by Dandia, to obtain a series of novel efficiently regio- and stereoselective dispiropyrrolidinyl/thiapyrrolizidinyl hybrid molecules via the 1,3-dipolar cycloaddition of a benzo[1,4]oxazine-derived dipolarophile, isatin and sarcosine/1,3-thiazolane-4-carboxylic acid (Dandia et al., 2015). The dipolarophile was synthesized under catalyst-free conditions from o-aminophenol and dimethyl acetylene dicarboxylate (DMAD) in good yields. The authors studied the cycloaddition reaction in different solvents (ethanol, methanol, acetonitrile, 1,4-dioxane, hexafluoro isopropanol, 2,2,2-trifluoroethanol, and toluene). The best results were obtained using 2,2,2-trifluoroethanol, which gave a single regioisomer in a higher yield and a shorter reaction time than the other solvents (92% yield). The reaction was complete in 30 min vs. the 6 h requested in presence of different solvents (Scheme 9).

SCHEME 9

Scheme 9. Synthesis of benzo[1,4]oxazine (X = O) and benzo[1,4]thiazine (X = S) based dispiroheterocycles via azomethine ylides.

The 1,3-dipolar cycloaddition reactions proceeded in a concerted manner, meaning that the reaction is stereospecific. In this case, the stereochemistry of alkene benzo[1,4]oxazine would influence the stereochemistry at positions 3 and 4. As described by the authors, the formation of only one diastereomer is explained by the plausible transition state (Scheme 10) which is somewhat promoted by a π-interaction between the aromatic rings as well as the secondary orbital interaction (SOI) between the ylide and the orbitals of the dipolarophile's carbonyl group.

SCHEME 10

Scheme 10. Plausible transition state.

1,3-Dipolar Cycloaddition in Water

The use of water in organic synthesis has stimulated several applications. Despite water's unique properties, it is still not commonly used as most organic compounds do not dissolve in water, meaning that a cosolvent is needed to increase solubility. This choice tends to diminish the advantages of low cost, no-toxicity, ease workup, and product isolation in water. Therefore, organic synthesis in aqueous media includes a large number of reactions that are performed both in homogeneous and in heterogeneous conditions (Chanda and Fokin, 2009).

As described by Sharpless et al. in their study of pericyclic cycloaddition, such reactions often benefit from working in water even when the organic reactants are insoluble in the aqueous phase. In fact, this substantial rate acceleration can be due to “on water” conditions that are created when insoluble reactants are stirred in an aqueous suspension (Narayan et al., 2005). This concept has been studied and applied to several different reactions. Even when the rate acceleration is negligible, this approach can still be considered successful as it makes product isolation easier and improves safety thanks to water's high redox stability and heat capacity.

Useful information derived from comparative studies of 1,3-dipolar cycloaddition reactions in organic solvents and water. The introduction of water as a cosolvent in cycloaddition reactions in organic solvents, such as acetonitrile and acetone, gave remarkable exponential rate increases as the solvent mixture approached pure water (Butler et al., 2004). Reactions of methyl vinyl ketone, ethyl vinyl ketone, and but-3-yn-2-one with pyridazine dicyanomethanide 1,3-dipole, which is soluble in water, display rate enhancements on changing from MeCN to H₂O (Figure 1). As observed in pericyclic cycloadditions, such as the Diels Alder reaction, the rate enhancement may be due to: (a) hydrophobic effects, which aggregate the organic reactants; (b) a lowering of the activation energy by special hydrogen bonding in the transition state; and (c) the fact that the cycloaddition transition state in water has higher polarity than its analog in organic solvents and, consequently, displays increased solvation stabilization in water (Butler et al., 2002).

FIGURE 1

Figure 1. Reprinted with permission from Butler et al. (2004). Copyright (2018) American Chemical Society.

The vast literature on the use of nitrones in the preparation of bioactive compounds pays testament to their huge synthetic potential. 1,3-dipolar nitrone-olefin cycloaddition has been used to obtain isoxazolidines, and even more complex bi- or tri-cyclic isoxazolidines, of biological interest and others that are useful synthetic intermediates for target molecules (De March et al., 1999; Fisera, 2007; Molteni, 2016). The fact that the formation of nitrones is due to the dehydration reactions of substituted hydroxylamine and carbonyl compounds drove A. Chatterjee et al. to explore the formation of nitrones in aqueous media using surfactants. As depicted in Figure 2, the micelles are hydrophobic and protect water-labile molecules from hydrolytic decomposition (Chatterjee et al., 2003).

FIGURE 2

Figure 2. Schematic representation of nitrones synthesis in micelle.

The authors started with a model reaction between phenyl hydroxylamine and various aldehydes, in which cetyl trimethylammonium bromide (CTAB) showed better performance than sodium dodecyl sulfate (SDS) in preparing nitrones. This is presumably due to stronger binding with the substrate. Interestingly, no reaction was observed when the reaction was performed in water in the absence of a surfactant or neat. The same procedure was therefore used to obtain a stereoselective intramolecular nitrone cycloaddition (Chatterjee and Bhattacharya, 2006). Furanoside-5-aldehydes derivatives were reacted with phenyl hydroxylamine to form the corresponding nitrones in aqueous media and the reaction was catalyzed by a surfactant at room temperature. The nitrone intermediate underwent stereoselective intramolecular cycloaddition as described in Scheme 11. Interestingly, the authors observed the formation of only one of the four possible isomers in these surfactant-mediated intramolecular nitrone cycloadditions. The nitrones of 3-O-allyl glucofuranose produce bridged isoxazolidines-oxepanes, as do the nitrones of crotyl derivatives. By contrast, nitrones of prenyl derivatives produce pyrans. This may be due to methyl-methyl steric repulsion restricting the formation of the oxepane skeleton.

SCHEME 11

Scheme 11. 1,3-dipolar cycloaddition with furanoside-5-aldehydes derivatives and phenyl hydroxylamine.

Several other attempts to perform 1,3-dipolar cycloadditions in the presence of previously synthesized nitrones have been performed in water without the addition of a surfactant. N-methyl-α-chloro nitrone reacted quickly with ethyl acrylate, styrene and three different maleimides (N-methyl/phenyl/cyclohexyl) (Scheme 12). Yields were in the range of 91–97% and the ratio anti/syn was 7:3 in average (Chakraborty et al., 2010, 2012).

SCHEME 12

Scheme 12. 1,3-dipolar cycloaddition of N-methyl-α-chloronitrone.

The 1,3-dipolar cycloaddition of nitrones in water has also been used to react two free sugar derivatives to produce pseudo-disaccharides, which bear imino-galactofuranose and galactofuranose units, in a 51% yield (Liautard et al., 2008). The reaction exploited the reactivity of water soluble nitrones with high enantioselectivity.

Triphenylphospine and tertiary amines can be used to activate conjugated carbonyl alkynes toward 1,3-dipolar cycloaddition. In fact, β-phosphonium (or ammonium) allenolates perform as reactive dipolarophiles in aqueous 1,3-dipolar cycloadditions and have been used to give 2,3-dihydroisoxazole (Scheme 13) (Gonzalez-Cruz et al., 2006). The reaction increased the reaction yield up to 68% when LiCl was used and interestingly only one regioisomer was isolated, while no reaction was observed in toluene and DCM. By comparison with tertiary amines, PPh₃ showed the best catalytic activity in the presence of aromatic nitrone (68% yield vs. 59%), while quinuclidine was more active with aliphatic nitrones. As has already been reported, reagents solubility in water is not required as they react in suspension (“on water”).

SCHEME 13

Scheme 13. Dipolar cycloaddition of β-phosphonium (or ammonium) allenolates to obtain isoxazolidine derivatives.

A catalytic amount of γ-cyclodextrin (γ-CD) has been used by G. Floresta et al., to produce 3,5-diarylisoxazolidines via the 1,3-dipolar cycloaddition of several p-substituted nitrones, styrenes and cinnamate derivatives (Floresta et al., 2017). The cyclodextrin cavity acted as a reactor and heating at 100°C for 8–12 h gave a set of derivatives in good yields with moderate to excellent diastereoselectivity. Interestingly, β-CD was inactive as a nano-reactor, while γ-CD was found to efficiently form inclusion complexes. The formation of the complex was confirmed by HR FT-ICR MALDI-MS Studies and NMR spectra. The authors rationalized by an in silico study the cycloaddition process and an E-endo transition state and that the cis major adduct is the more reactive rotamer of the nitrone. The calculation suggests that the transition stage is positioned within the CD reactor, as depicted in Scheme 14.

SCHEME 14

Scheme 14. Schematic representation of synthesis of 3,5-diarylisoxazolidines via the 1,3-dipolar cycloaddition in presence of γ-CD and plausible transition stage to obtain the major E-endo derivative. The image was reprinted adapted with permission from Floresta et al. (2017). Copyright (2018) American Chemical Society.

In 2008, an interesting publication demonstrated the influence that the solvent can have on the production of isoxazolidine. Alkenylazaarenes were utilized as dipolarophiles for the preparation of 4-substituted and 5-substituted isoxazolidines with nitrones giving high regioselectivity under a range of reaction conditions. Reaction in water under microwave in a sealed vessel gave in high to excellent yields only 5-substituted isoxazolidines, while the 4-substituted analogs were obtained as the major products when a Lewis acid, TMSOTf, was used as the catalyst in DCM at room temperature (Scheme 15) (Tong et al., 2018).

SCHEME 15

Scheme 15. Synthesis of 5-substituted isoxazolidines with nitrones in water under microwave irradiation.

Oxindole derivatives that bear a spirocyclic quaternary stereocentre at the C3 position are interesting heterocyclic motifs generally found in a number of natural products and drugs.

Several green approaches for the synthesis of spiro-indole have been described as occurring in the presence of water as a solvent. Despite the common use of halogenated organic solvents, the “on-water” generation of carbonyl ylides using carbenoids was described in 2015 (Muthusamy and Ramkumar, 2015). The proposed synthesis catalyzed by rhodium(II) acetate dimer, afforded spiro-oxiranes from carbonyl ylide dipoles and diazoamides (3-diazooxindoles) (Scheme 16). Spiro-dioxolanes were obtained with complete diastereoselectivity when carbonyl ylides were obtained using aromatic aldehydes with electron-withdrawing substituents, while with electron-donating substituents the 1,3-dipolar cycloaddition reactions were observed.

SCHEME 16

Scheme 16. Schematic representation of spiro-indole synthesis from 3-diazooxindole derivatives.

The reaction afforded cis products in both the spiro-oxirane and spiro-dioxolane syntheses. In the presence of 1.2 equivalents of aromatic aldehyde, the acyclic carbonyl ylide underwent the intermolecular stereoselective dipolar cyclization in a particular conformation, which involved an intramolecular hydrogen bond, to give epoxides (Scheme 17). When an excess of aldehyde was used (4 equivalents), the reaction happened “on water” as the nucleophilic addition of water was not observed to occur. Nevertheless, the free interfacial-water OH groups may stabilize the possible transition state.

SCHEME 17

Scheme 17. Proposed mechanism.

A three-component, 1,3-dipolar cycloaddition of in situ generated azomethine ylides from isatin derivatives and benzylamine, with benzylideneacetone can be employed to give spiro-pyrrolidine-oxindoles (Peng et al., 2014). This reaction can be performed in water to give the desired product in a 23% yield and a 68:32 regioisomeric ratio.

The use of Lewis acids, such as Ceric Ammonium Nitrate (CAN) or TiO₂, in the formation of spirooxindoles in water has been investigated, giving excellent results (Scheme 18) (Ramesh et al., 2016, 2018). The 1,3-dipolar cycloaddition was performed with 1 mol% of CAN in 2 h, while the reaction was complete after 30 min when heterogeneous TiO₂ nanoparticles were used. Both reactions showed excellent regioselectivity and stereoselectivity, and the TiO₂ nanocatalyst was reused 5 times without losing catalytic activity. 20 different spirooxindole-pyrrolidines were obtained, in 65–90% yields with CAN and the reaction showed increased average yield in the presence of TiO₂.

SCHEME 18

Scheme 18. Synthesis of spiroindole by 1,3-dipolar cycloaddition with TiO₂ in water and with CAN in solvent.

Diazoalkanes can be generated from the decomposition of tosylhydrazones and are efficient 1,3-dipoles exploitable for the synthesis of several nitrogen containing heterocycles (Munro and Sharp, 1984). An intramolecular 1,3-dipolar cycloaddition strategy for rapid access to pyrazoles or triazoles makes use of the in situ generated diazomethanes, in a two-step sequence, in which diazomethanes undergo smooth cycloaddition with alkyne or nitrile moieties (Padwa and Ku, 1980). As described in Scheme 19, this process can be used as a step-economical route to benzopyranopyrazole from propargylated salicylaldehydes and tosyl hydrazone. This reaction, which is usually performed in DMF, can be performed in water with K₂CO₃, providing excellent yields (more than 80%).

SCHEME 19

Scheme 19. Synthesis of benzopyranopyrazole from propargylated salicylaldehydes and tosyl hydrazine.

Organo-Catalyzed and Catalyst-Free 1,3-Dipolar-Cycloaddition

A novel organocatalytic asymmetric 1,3-dipolar addition has been proposed by MacMillan, that explored the synthesis of oxazolidine starting from nitrones and α,β- unsaturated aldehydes (Jen et al., 2000). In the presence of different chiral imidazolidinone·HCl the reaction between crotonaldehyde and N-benzyl phenyl nitrone showed moderate to high yield (45–77%) and ee (42–93%); when a Brønsted acid was added as co-catalyst, the efficient iminium activation could increase yield (98%) and ee (94%).

In 2007 Córdova et al. proposed an enantioselective organocatalyzed synthesis of substituted oxazolidine. N-arylhydroxylamines, aldehydes, and α,β-unsaturated aldehydes were reacted in the presence of a chiral organic catalyst. The in-situ generated nitrone reacted with activated enal, in chloroform or THF at room temperature (16 h) to give the isoxazolidine as a single diastereomer (>25:1 endo:exo). TMS protected diarylprolinol gave ee % up to 98% (Scheme 20) (Rios et al., 2007).

SCHEME 20

Scheme 20. Enantioselective synthesis of substituted isoxazolidine.

Organo-catalyzed (3+2) dipolar cycloadditions of azomethineylide with various dipolarophiles has been the object of intense investigation. Several publications studied iminoesters as the precursors of stabilized azomethine ylides, because, as described in the scheme, they can undergo thermal tautomerism to produce azomethine ylides (Scheme 21).

SCHEME 21

Scheme 21. Schematic representation of iminoesters as the precursors of stabilized azomethine ylides.

Vicario et al. observed that cycloaddition of imine and crotonaldehyde catalyzed diphenylprolinol provided a single endo isomer with excellent enantioselectivity (Vicario et al., 2007). The authors highlighted the fundamental role of free OH groups on the catalyst and the acceleration rate by water addition. The optimized protocol was performed at 4°C in THF. Similarly, Cordoba et al. proposed the synthesis of pyrrolidine in CHCl₃, at room temperature with protected prolinol. As described in Scheme 22, a slightly lower yield and selectivity were observed (Ibrahem et al., 2007).

SCHEME 22

Scheme 22. Enantioselective synthesis of substituted pyrrolidines.

An elegant example of 1,3-dipolar cycloaddition in asymmetric catalysis has been published by the Córdova group, which proved that a hydrogen bond donating network with a co-catalyst was to direct the cycloaddition by locking the conformation of the intermediate so to achieve a highly selective reaction (Lin et al., 2011). This dynamic one pot reaction was directed to cycloaddition in THF or DMF and the presence of hydrogen bond donating molecules such as oximes was favorable for the acceleration of the reaction when the substrate was cyanoacetate or α-cyanoglycine. Compared to the previously described approach, this one pot reaction generated four contiguous chiral centers including a quaternary carbon. As described in the scheme, the proposed mechanism involves the prototropy of the imine cyanoglycine so that the H bond activate the iminium salt and lock is conformation as 1 (see Scheme 23) stereoselective ccloaddition from the Re face of intermediate 3 by and endo mechanism.

SCHEME 23

Scheme 23. One pot Three component catalytic asymmetric synthesis of pyrazolidine.

Another recent approach to activate different dipolarophiles other than unsaturated aldehydes was pursued by Chen et al. and chiral phosphoric acids were successfully exploited to obtain pyrrolidine or spirooxindole (Chen et al., 2009; Chang et al., 2016). Excellent yield and enantioselectivity were obtained in DCM at room temperature with chiral sterically hindered phosphoric acids for the imine activation (see Scheme 24).

SCHEME 24

Scheme 24. Organocatalytic synthesis of spiro[pyrrolidin-3,3′-oxindoles].

Pyrazoles are known to be potent insecticides and herbicides, and have been also studied for their anti-tumor, anti-inflammatory, anti-microbial and anti-psychotic properties. Diazo compounds may react with alkynes to provide efficient synthesis of pyrazole via 1,3-dipolar cycloaddition. The 1,3-dipolar cycloaddition of alkynes to electron-rich diazo compounds has been described, whereas the intermolecular 1,3-dipolar cycloaddition of alkynes with electron-poor diazocarbonyl compounds is much less often reported because of the to the high HOMO–LUMO energy difference between alkynes and diazocarbonyl compounds. In presence of Lewis acid or transition metals LUMO of the alkyne dipolarophiles is lowered. Wang et al. (2013) developed an organocatalytic inverse-electron-demand [4+2] cycloaddition between diazoacetates and various carbonyl compounds. Secondary amines we employed as “green promoters,” to catalyze the cycloaddition reaction and produce the target pyrazole ring (Scheme 25). Pyrrolidine was selected as the most effective catalyst and DMSO as best solvent for this transformation. The optimized protocol was performed in DMSO at room temperature with 10 mol% of pirrolidine and a 1:2 ratio of diazoacetates and carbonyl compounds.

SCHEME 25

Scheme 25. Polysubstituted pyrazoles synthetic route from diazoacetates and carbonyl compounds.

When the reaction was performed with unsymmetrical cyclic ketones, high levels of regioselectivity were achieved. Nonetheless, the authors discovered that in the reaction between diazoacetates and aldehydes, it performed better in presence of acyclic secondary diethyl amine catalysis. Moderate-to-excellent yields of the corresponding adducts were obtained also varying the side-chain of the carbonyl group.

The hypothesis of selective C-H₁ bond-breaking was confirmed by a deuterium labeling experiment. The enamine-promoted cycloaddition reaction with α-deuterated benzyl diazoacetate yielded the final compound without any deuterium being incorporated into the pyrazole ring, which supports the hypothesis of a selective C-H₁ bond breaking. The authors supposed that the C-H₁ bond is activated by the adjacent electron-withdrawing ester group, toward the selective cleavage over the C-H₂ bond. The final product derived from an elimination step followed by tautomerization (Scheme 26).

SCHEME 26

Scheme 26. Postulated reaction pathway.

Liu et al. (2017) have presented the first catalyst-free 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines and 3-nitroindoles to prepare highly functionalised, five-ring-fused tetrahydroisoquinolines, which feature an indoline scaffold with excellent diastereoselectivity. The reaction performed the use of catalysts or additives and more than 95% yield was obtained in EtOAc (Scheme 27). In the presence of 20 mol% Cu(OTf)₂ in CHCl₃ the cycloaddition reaction afforded the corresponding product with only 23% conversion after 24 h at room temperature. When Ni(OAc)₂·4H₂O was used in CHCl₃, the conversion was enhanced to 89%. N-tosyl and N-alkoxycarbonylated protected, 3-nitroindoles performed very well giving in high yields the corresponding cycloadducts. Because of its reduced electrophilicity N-Methyl-protected 3-nitroindole failed to undergo the transformation. The versatility of this method was demonstrated with a list of structurally different C,N-cyclic azomethine imines.

SCHEME 27

Scheme 27. Synthesis of polycyclic tetrahydroisoquinoline derivatives.

1,2,3-triazoles have a wide range of applications as potential bioactive compounds and are often used in drugs synthesis. A general and efficient method for their fabrication came in the early 2000s with the novel concept of “click” chemistry and the Cu-catalyzed alkyne–azide cycloaddition reaction provides the regioselective formation of 1,4-disubstituted 1,2,3-triazoles. The metallo-catalyzed alkyne–azide cycloaddition reaction for the formation of 1,5-disubsituted 1,2,3-triazoles was published later. However, the reactions mentioned above have made use of heavy metals, which has limited their practical applications.

Alternative synthetic pathways for 1,2,3-triazoles have also been developed and 1,2,3 triazoles have freely been obtained from a combination of azides with a range of reaction partners: e.g., cycloadditions of either β-keto esters or nitriles to azides catalyzed by secondary amines (Costa et al., 2017), cycloaddition of a triple domino sequence of reactions between azide, amine, and 5-bromo-2-furylcarbinol (Yang et al., 2015), the reaction of enols and enamines with azides (Blastik et al., 2018), nitro methylene-based three-component synthesis (Thomas et al., 2014), and others. However, these methods entail the use of organic azides or sodium azides, which are difficult to handle and toxic, particularly on a large scale. In a 2017 review, Ahmed (Ahmed et al., 2017) presented some less well-known synthetic protocols for 1,2,3-triazoles under azide-free and metal-free environments (Figure 3).

FIGURE 3

Figure 3. “Metal-free” and “azide-free” syntheses of triazoles.

Light Induced

The importance of aza-heterocycles relates to their presence as natural products, drugs and biologically relevant compounds. A variety of methods have been developed for the synthesis of 1,2,4-oxadiazolines, and these are typically carried out via the [4+2] cycloaddition of an imine with a nitrile oxide (generated in situ from hydroxamoyl chloride or nitroalkane). The design of a new synthetic path of 1,2,4-oxadiazolines, especially greener methods, is highly desirable because many of these methods suffer from one or more drawbacks. Soni et al. (2018) have very recently presented a greener method for the synthesis of 1,2,4-oxadiazolines via an intramolecular oxidative cyclisations of amidoximes in the presence of an organocatalyst and molecular oxygen. The authors optimized the reaction conditions to give 3-phenyl- 5,6,7,7a-tetrahydropyrrolo[1,2-d][1,2,4]oxadiazole from phenyl(pyrrolidin- 1-yl)methanone oxime, which was used as a model substrate. The optimized conditions involved 2 mol% of an organophotocatalyst, 2,4,6- tris(4-fluorophenyl)pyrylium tetrafluoroborate [T(p-F)PPT] at a 0.2 M concentration in DMF under an atmosphere of molecular oxygen. Visible-light irradiation was provided by a compact fluorescent lamp (CFL, 23 W). Organophotocatalyst can reduce the drawbacks of transition metals related to toxicity and the low residues admitted in pharmaceutical products (Scheme 28).

SCHEME 28

Scheme 28. Synthesis of bicyclic 1,2,4-oxadiazolines.

The authors investigated several pyrrolidinyl oxime derivatives both with electron-withdrawing and electron-donating substituents, for the oxidative cyclization to 1,2,4-oxadiazolines with a mechanism as proposed in Scheme 29.

SCHEME 29

Scheme 29. Plausible mechanism for the synthesis of 1,2,4-oxadiazolines.

It was observed that triphenylpyrylium (TPP) derivatives were the only effective photocatalysts among those examined, with conversion even in absence of light. As described in the Scheme 29, the reaction begins with the nucleophilic addition to the triphenylpyrylium ion (A) toward intermediate B. Molecular oxygen provides the oxidation of C by regenerates catalyst A. The iminyloxyl radical D undergoes an intramolecular 1,5- hydrogen atom transfer (HAT) to the radical E, which is then oxidized to the iminium ion F. The final 1,2,4-oxadiazoline is generated by intramolecular cyclization of F.

Visible-light-driven photoredox catalysis is attracting interest because of its inherent features of green chemistry and sustainability. In addition to a number of radical reactions, several [2+3] cycloaddition applications have been described in the existing literature (Narayanam and Stephenson, 2011; Nakajima et al., 2016; Staveness et al., 2016; Savateev and Antonietti, 2018).

2H-azirines can react with activated alkynes or aldehydes to produce polysubstituted pyrroles or 2,5-dihydrooxazole, respectively, under very mild reaction conditions (visible-light irradiation, metal-free, and room temperature). As described by Xuan et al., the optimized procedure is catalyzed by 9-mesityl-10-methyl-acridinium perchlorate in dichloroethane under irradiation from a 3 W white LED light. Excellent results were obtained when a range of substituted 2H-azirines were reacted with dimethyl but-2-yne-dioate (Xuan et al., 2014). 2H-Azirines reacted with aldehydes in the presence of Li₂CO₃. This was done to avoid the oxidation of aldehydes to carboxylic acids, and 2,3-dichloro5,6-dicyano-1,4-benzoquinone (DDQ) was added to the reaction system in order to perform the one pot synthesis of oxazole. The applicability of the reactions was demonstrated using a panel of 12 2,4,5 trisubstituted oxazoles, giving yields in the 40–80% range (Scheme 30) (Zeng et al., 2015).

SCHEME 30

Scheme 30. Visible-light mediated synthesis of pyrroles and isozazoles from of 2H-azirines and 2H-oxazirine.

The ring-opening of 2H-oxazirine has been described as occurring via visible-light-mediated photoredox-catalyzed single-electron transfer (SET), giving nitrone precursors. The 1,3-dipolar cycloaddition was therefore used for the synthesis of 4-isoxazolines. 9-mesityl-10-methyl-acridinium perchlorate was the strategic choice of catalyst because of its high oxidizing power (+2.06 V). The [3 + 2] cycloaddition reaction of oxaziridine with dimethyl acetylenedicarboxylate gave very good results when performed in CH₃CN in the presence of water, used as an additive, and a large set of 4-isoxazolines was synthesized with a good average yield.

The first attempt to describe the mechanism of pyrrole cyclization focused on a radical cycloaddition of the intermediate 2-azaallenyl radical cation, which was in equilibrium with a 1,3-radical-cationic species. Subsequently, the publication mentioned the synthesis of the dihydroisoxazole by an hypothesis of a polar cycloaddition. In fact, the authors proposed the single-electron reduction of the nitrone radical to a nitrone species.

Author Contributions

All the authors contributed equally to the review preparation. GC supervised the work and edited the final version.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Acknowledgments

Authors acknowledge the University of Turin (Ricerca locale 2017) and the Sechenov University for the financial support.

References

Ahmed, M., Razaq, H., Faisal, M., Siyal, A. N., and Haider, A. (2017). Metal-free and azide-free synthesis of 1,2,3-triazoles derivatives. Synth. Commun. 47, 1193–1200. doi: 10.1080/00397911.2017.1303511

CrossRef Full Text | Google Scholar

Almansour, A. I., Arumugam, N., Kumar, R. S., Periyasami, G. A., Ghabbour, H., and Fun, H. K. (2015). A novel one-pot green synthesis of dispirooxindolo-pyrrolidines via 1,3-dipolar cycloaddition reactions of azomethine ylides. Molecules 20, 780–791. doi: 10.3390/molecules20010780

PubMed Abstract | CrossRef Full Text | Google Scholar

Anastas, P., and Eghbali, N. (2010). Green chemistry: principles and practice. Chem. Soc. Rev. 39, 301–312. doi: 10.1039/B918763B

PubMed Abstract | CrossRef Full Text | Google Scholar

Arumugam, N., Almansour, I. A., Kumar, S. R., Menéndez, C. J., Sultan, A. M., Karama, U., et al. (2015). An expedient regio- and diastereoselective synthesis of hybrid frameworks with embedded spiro[9,10]dihydroanthracene [9,3′]-pyrrolidine and Spiro[oxindole-3,2′-pyrrolidine] motifs via an ionic liquid-mediated multicomponent reaction. Molecules 20, 16142–16153. doi: 10.3390/molecules200916142

CrossRef Full Text | Google Scholar

Blastik, Z. E., Klepetářová, B., and Beier, P. (2018). Enamine-mediated azide-ketone [3 + 2] cycloaddition of azidoperfluoroalkanes. Chem. Select 3, 7045–7048. doi: 10.1002/slct.201801344

CrossRef Full Text | Google Scholar

Butler, R. N., and Coyne, A. G. (2016). Organic synthesis reactions on-water at the organic–liquid water interface. Org. Biomol. Chem. 14, 9945–9960. doi: 10.1039/C6OB01724J

PubMed Abstract | CrossRef Full Text | Google Scholar

Butler, R. N., Coyne, A. G., Cunningham, W. J., and Burke, L. A. (2002). Kinetic and synthetic influences of water and solvent-free conditions on 1,3-dipolar cycloaddition reactions: the phthalazinium and pyridazinium dicyanomethanide 1,3-dipoles: surprisingly successful synthetic methods. J. Chem. Soc. Perkin Trans. 2, 1807–1815. doi: 10.1039/b206028k

CrossRef Full Text | Google Scholar

Butler, R. N., Cunningham, W. J., Coyne, A. G., and Burke, L. A. (2004). The influence of water on the rates of 1,3-dipolar cycloaddition reactions: trigger points for exponential rate increases in water–organic solvent mixtures. water-super versus water-normal dipolarophiles. J. Am. Chem. Soc. 126, 11923–11929. doi: 10.1021/ja040119y

PubMed Abstract | CrossRef Full Text | Google Scholar

Chakraborty, B., Samanta, A., Sharma, P. K., Chhetri, M. S., Kafley, S., Banerjee, A., et al. (2010). One pot high yield synthesis of some novel isoxazolidine derivatives using N-methyl-α-chloro nitrone in water and their antibacterial activity. J. Chem. Pharm. Res. 2, 727–739.

Google Scholar

Chakraborty, B., Sharma, P. K., and Chhetri, M. S. (2012). High yield one-pot synthesis of some novel N-methyl isoxazolidine derivatives using N-methyl-α-chloro nitrone in water. J. Heterocycl. Chem. 49, 1260–1265. doi: 10.1002/jhet.971

CrossRef Full Text | Google Scholar

Chanda, A., and Fokin, V. V. (2009). Organic synthesis “On Water”. Chem. Rev. 109, 725–748. doi: 10.1021/cr800448q

PubMed Abstract | CrossRef Full Text | Google Scholar

Chang, G. H., Wang, C. Y., Madhusudhan Reddy, G., Tsai, Y. L., and Lin, W. (2016). Enantioselective synthesis of polysubstituted benzopyrano[3,4-c]pyrrolidine frameworks via [3 + 2] cycloaddition of azomethine ylides and coumarin derivatives. J. Org. Chem. 81, 10071–10080. doi: 10.1021/acs.joc.6b02041

PubMed Abstract | CrossRef Full Text | Google Scholar

Chatterjee, A., and Bhattacharya, P. K. (2006). Stereoselective synthesis of chiral oxepanes and pyrans through intramolecular nitrone cycloaddition in organized aqueous media. J. Org. Chem. 71, 345–348. doi: 10.1021/jo051414j

PubMed Abstract | CrossRef Full Text | Google Scholar

Chatterjee, A., Maiti, D. K., and Bhattacharya, P. K. (2003). Water exclusion reaction in aqueous media: nitrone formation and cycloaddition in a single pot. Org. Lett. 5, 3967–3969. doi: 10.1021/ol035535m

PubMed Abstract | CrossRef Full Text | Google Scholar

Chen, X.-H., Wei, Q., Luo, S.-W., Xiao, H., and Gong, L.-Z. (2009). Organocatalytic synthesis of spiro[pyrrolidin-3,3′-oxindoles] with high enantiopurity and structural diversity. J. Am. Chem. Soc. 131, 13819–13825. doi: 10.1021/ja905302f

PubMed Abstract | CrossRef Full Text | Google Scholar

Costa, G. P., Seus, N., Roehrs, J. A., Jacob, R. G., Schumacher, R. F., Barcellos, T., et al. (2017). Ultrasound-promoted organocatalytic enamine-azide [3 + 2] cycloaddition reactions for the synthesis of ((arylselanyl)phenyl-1H-1,2,3-triazol-4-yl)ketones. Beilstein J. Org. Chem. 13, 694–702. doi: 10.3762/bjoc.13.68

PubMed Abstract | CrossRef Full Text | Google Scholar

Dandia, A., Jain, A. K., and Sharma, S. (2012). An efficient and highly selective approach for the construction of novel dispiro heterocycles in guanidine-based task-specific [TMG][Ac] ionic liquid. Tetrahedron Lett. 53, 5859–5863. doi: 10.1016/j.tetlet.2012.08.060

CrossRef Full Text | Google Scholar

Dandia, A., Singh, R., Khan, S., Kumari, S., and Soni, P. (2015). A rational eco-compatible design strategy for regio- and diastereoselective synthesis of novel dispiropyrrolidine/thiapyrrolizidine hybrids. Tetrahedron Lett. 56, 4438–4444. doi: 10.1016/j.tetlet.2015.04.130

CrossRef Full Text | Google Scholar

De March, P., Figueredo, M., and Font, J. (1999). 1,3-Dipolar cycloadditions of five and six membered cyclic nitrones to α,β-unsaturated acid derivatives. Heterocycles 50, 1213–1226. doi: 10.3987/REV-98-SR(H)10

CrossRef Full Text | Google Scholar

Fisera, L. (2007). 1,3-dipolar cycloadditions of sugar-derived nitrones and their utilization in synthesis. Top. Heterocycl. Chem. 7, 287–323. doi: 10.1007/7081_2007_076

CrossRef Full Text | Google Scholar

Floresta, G., Talotta, C., Gaeta, C., De Rosa, M., Chiacchio, U., Neri, P., et al. (2017). γ-Cyclodextrin as a catalyst for the synthesis of 2-methyl-3,5-diarylisoxazolidines in water. J. Org. Chem. 82, 4631–4639. doi: 10.1021/acs.joc.7b00227

PubMed Abstract | CrossRef Full Text | Google Scholar

Garella, D., Borretto, E., Di Stilo, A., Martina, K., Cravotto, G., and Cintas, P. (2013). Microwave-assisted synthesis of N-heterocycles in medicinal chemistry. MedChemComm 4, 1323–1343. doi: 10.1039/c3md00152k

CrossRef Full Text | Google Scholar

Gonzalez-Cruz, D., Tejedor, D., de Armas, P., Morales, E. Q., and Garcia-Tellado, F. (2006). Organocatalysis “on water”. regioselective [3 + 2]-cycloaddition of nitrones and allenolates. Chem. Commun. 2798–2800. doi: 10.1039/B606096J

PubMed Abstract | CrossRef Full Text | Google Scholar

Ibrahem, I., Rios, R., Vesely, J., and Córdova, A. (2007). Organocatalytic asymmetric multi-component [C+NC+CC] synthesis of highly functionalized pyrrolidine derivatives. Tetrahedron Lett. 48, 6252–6257. doi: 10.1016/j.tetlet.2007.07.031

CrossRef Full Text | Google Scholar

Jadidi, K., Mojtaba Mirhosseini, M., Aghapoor, K., and Gharemanzadeh, R. (2007). The synthesis of novel pyrrolizidines under classical, ionic liquid and solvent-free microwave-assisted conditions. J. Chem. Res. 2007, 71–73. doi: 10.3184/030823407X198258

CrossRef Full Text | Google Scholar

Jain, R., Sharma, K., and Kumar, D. (2012). Ionic liquid mediated 1,3-dipolar cycloaddition of azomethine ylides: a facile and green synthesis of novel dispiro heterocycles. Tetrahedron Lett. 53, 1993–1997. doi: 10.1016/j.tetlet.2012.02.029

CrossRef Full Text | Google Scholar

Jen, W. S., Wiener, J. J. M., and MacMillan, D. W. C. (2000). New strategies for organic catalysis: the first enantioselective organocatalytic 1,3-dipolar cycloaddition. J. Am. Chem. Soc. 122, 9874–9875. doi: 10.1021/ja005517p

CrossRef Full Text | Google Scholar

Kathiravan, S., and Raghunathan, R. (2013). Synthesis of pyrrolo[2,3-a]pyrrolizidino derivatives through intramolecular 1,3-dipolar cycloaddition in ionic liquid medium. Synth. Commun. 43, 147–155. doi: 10.1080/00397911.2011.594545

CrossRef Full Text | Google Scholar

Kumar, R. S., Almansour, A. I., Arumugam, N., Menéndez, J. C., Osman, H., and Kumar, R. R. (2015). Dipolar cycloaddition-based multicomponent reactions in ionic liquids: a green, fully stereoselective synthesis of novel polycyclic cage systems with the generation of two new azaheterocyclic rings. Synthesis 47, 2721–2730. doi: 10.1055/s-0034-1379931

CrossRef Full Text | Google Scholar

Liautard, V., Desvergnes, V., and Martin, O. R. (2008). Novel galf-disaccharide mimics: synthesis by way of 1,3-dipolar cycloaddition reactions in water. Tetrahedron 19, 1999–2002. doi: 10.1016/j.tetasy.2008.08.006

CrossRef Full Text | Google Scholar

Lin, S., Deiana, L., Zhao, G. L., Sun, J., and Córdova, A. (2011). Dynamic one-pot three-component catalytic asymmetric transformation by combination of hydrogen-bond-donating and amine catalysts. Angew. Chem. Int. Ed. 50, 7624–7630. doi: 10.1002/anie.201101966

PubMed Abstract | CrossRef Full Text | Google Scholar

Liu, X., Yang, D., Wang, K., Zhang, J., and Wang, R. (2017). A catalyst-free 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines and 3-nitroindoles: an easy access to five-ring-fused tetrahydroisoquinolines. Green Chem. 19, 82–87. doi: 10.1039/C6GC02517J

CrossRef Full Text | Google Scholar

Molteni, G. (2016). Dipolar cycloadditions of nitrones in aqueous media. Heterocycles 92, 2115–2140. doi: 10.3987/REV-16-848

CrossRef Full Text | Google Scholar

Moulay, S., and Touati, A. (2010). Cycloaddition reactions in aqueous systems: a two-decade trend endeavor. Comptes Rendus Chimie 13, 1474–1511. doi: 10.1016/j.crci.2010.05.025

CrossRef Full Text | Google Scholar

Munro, D. P., and Sharp, J. T. (1984). Electrocyclic aromatic substitution by the diazo group. Part 5. The reactions of α-(2-arylthienyl)diazoalkanes. J. Chem. Soc. Perkin Trans. 1, 571–574. doi: 10.1039/P19840000571

CrossRef Full Text | Google Scholar

Muthusamy, S., and Ramkumar, R. (2015). ‘On-water' generation of carbonyl ylides from diazoamides: rhodium(II) catalyzed synthesis of spiroindolo-oxiranes and -dioxolanes with an interesting diastereoselectivity. Tetrahedron 71, 6219–6226. doi: 10.1016/j.tet.2015.06.076

CrossRef Full Text | Google Scholar

Nakajima, K., Miyake, Y., and Nishibayashi, Y. (2016). Synthetic utilization of α-aminoalkyl radicals and related species in visible light photoredox catalysis. Acc. Chem. Res. 49, 1946–1956. doi: 10.1021/acs.accounts.6b00251

PubMed Abstract | CrossRef Full Text | Google Scholar

Narayan, S., Muldoon, J., Finn, M. G., Fokin, V. V., Kolb, H. C., and Sharpless, K. B. (2005). “On Water”: unique reactivity of organic compounds in aqueous suspension. Angew. Chem. Int. Ed. 44, 3275–3279. doi: 10.1002/anie.200462883

PubMed Abstract | CrossRef Full Text | Google Scholar

Narayanam, J. M., and Stephenson, C. R. (2011). Visible light photoredox catalysis: applications in organic synthesis. Chem. Soc. Rev. 40, 102–113. doi: 10.1039/B913880N

PubMed Abstract | CrossRef Full Text | Google Scholar

Padwa, A., and Ku, H. (1980). Intramolecular cycloaddition reactions of olefinic tosylhydrazones. J. Org. Chem. 45, 3756–3766. doi: 10.1021/jo01307a008

CrossRef Full Text | Google Scholar

Peng, C., Ren, J., Xiao, J. A., Zhang, H., Yang, H., and Luo, Y. (2014). Additive-assisted regioselective 1,3-dipolar cycloaddition of azomethine ylides with benzylideneacetone. Beilstein J. Org. Chem. 10, 352–360. doi: 10.3762/bjoc.10.33

PubMed Abstract | CrossRef Full Text | Google Scholar

Ramesh, P., Rao, K. S., Trivedi, R., Kumar, B. S., Prakasham, R. S., and Sridhar, B. (2016). Highly efficient regio and diastereoselective synthesis of functionalized bis-spirooxindoles and their antibacterial properties. RSC Adv. 6, 26546–26552. doi: 10.1039/C6RA00613B

CrossRef Full Text | Google Scholar

Ramesh, P., Reddy, M. S., Kumar, N. S., Rathod, B., Prakasham, R. S., and Chowan, L. R. (2018). TiO2 nanoparticle catalyzed rapid synthesis of spiroxindole-pyrrolidine in aqueous medium and evaluation of their antimicrobial properties. Chem. Select 3, 9096–9101. doi: 10.1002/slct.201801639

CrossRef Full Text | Google Scholar

Rios, R., Ibrahem, I., Vesely, J., Zhao, G.-L., and Córdova, A. (2007). A simple one-pot, three-component, catalytic, highly enantioselective isoxazolidine synthesis. Tetrahedron Lett. 48, 5701–5705. doi: 10.1016/j.tetlet.2007.05.176

CrossRef Full Text | Google Scholar

Rostovtsev, V. V., Green, L. G., Fokin, V. V., and Sharpless, K. B. (2002). A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective “Ligation” of azides and terminal alkynes. Angew. Chem. Int. Ed. 41, 2596–2599. doi: 10.1002/1521-3773(20020715)41:14<2596::AID-ANIE2596>3.0.CO;2-4

PubMed Abstract | CrossRef Full Text | Google Scholar

Savateev, A., and Antonietti, M. (2018). Heterogeneous organocatalysis for photoredox chemistry. ACS Catal. 8, 9790–9808. doi: 10.1021/acscatal.8b02595

CrossRef Full Text | Google Scholar

Soni, V. K., Kim, J., and Cho, E. J. (2018). Organocatalytic oxidative cyclization of amidoximes for the synthesis of 1,2,4-oxadiazolines. Adv. Synth. Cat. 360, 2626–2631. doi: 10.1002/adsc.201800238

CrossRef Full Text | Google Scholar

Staveness, D., Bosque, I., and Stephenson, C. R. (2016). Free radical chemistry enabled by visible light-induced electron transfer. Acc. Chem. Res. 49, 2295–2306. doi: 10.1021/acs.accounts.6b00270

PubMed Abstract | CrossRef Full Text | Google Scholar

Thomas, J., John, J., Parekh, N., and Dehaen, W. (2014). A metal-free three-component reaction for the regioselective synthesis of 1,4,5-trisubstituted 1,2,3-triazoles. Angew. Chem. Int. Ed. 53, 10155–10159. doi: 10.1002/anie.201403453

PubMed Abstract | CrossRef Full Text | Google Scholar

Tong, M., Zhang, Y., Qin, C., Fu, Y., Liu, Y., Li, H., et al. (2018). Alkenylazaarenes as dipolarophiles in 1,3-dipolar cycloaddition of nitrones: regioselectivity-switchable and highly diastereoselective synthesis of multisubstituted isoxazolidines. Org. Chem. Front. 5, 2945–2949. doi: 10.1039/C8QO00826D

CrossRef Full Text | Google Scholar

Tornøe, C. W., Christensen, C., and Meldal, M. (2002). Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(I)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. J. Org. Chem. 67, 3057–3064. doi: 10.1021/jo011148j

PubMed Abstract | CrossRef Full Text | Google Scholar

Vicario, J. L., Reboredo, S., Badía, D., and Carrillo, L. (2007). Organocatalytic enantioselective [3+2] cycloaddition of azomethine ylides and α,β-unsaturated aldehydes. Angew. Chem. Int. Ed. 46, 5168–5170. doi: 10.1002/anie.200700988

PubMed Abstract | CrossRef Full Text | Google Scholar

Wang, L., Huang, J., Gong, X., and Wang, J. (2013). Highly regioselective organocatalyzed synthesis of pyrazoles from diazoacetates and carbonyl compounds. Chemistry 19, 7555–7560. doi: 10.1002/chem.201300047

PubMed Abstract | CrossRef Full Text | Google Scholar

Xuan, J., Xia, X. D., Zeng, T. T., Feng, Z. J., Chen, J. R., Lu, L. Q., et al. (2014). Visible-light-induced formal [3+2] cycloaddition for pyrrole synthesis under metal-free conditions. Angew. Chem. Int. Ed. 53, 5653–5656. doi: 10.1002/anie.201400602

PubMed Abstract | CrossRef Full Text | Google Scholar

Yang, H., Gou, J., Guo, J., Duan, D., Zhao, Y. M., Yu, B., et al. (2015). Bifunctional furfuryl cations strategy: three-component synthesis of enamidyl triazoles. Chemistry 22, 129–133. doi: 10.1002/chem.201504330

PubMed Abstract | CrossRef Full Text | Google Scholar

Zeng, T. T., Xuan, J., Ding, W., Wang, K., Lu, L. Q., and Xiao, W. J. (2015). [3 + 2] Cycloaddition/oxidative aromatization sequence via photoredox catalysis: one-pot synthesis of oxazoles from 2H-azirines and aldehydes. Org. Lett. 17, 4070–4073. doi: 10.1021/acs.orglett.5b01994

PubMed Abstract | CrossRef Full Text | Google Scholar