In the original article, there was a mistake in Table 1 as published. In rows 6 to 10, the wrong references were listed for the findings summarized in these rows. Two additional references with findings were missing in the table due to this error. The corrected Table 1 appears below.
Table 1
| Reference | HVM | Study population | n | Area of interest | Findings |
|---|---|---|---|---|---|
| Genzel-Boroviczeny et al. (13) | OPS | Healthy preterm vs. term neonates | 28/9 | Cutaneous (upper inner arm) | Application OPS imaging; groups did not differ; RBC velocity increased from day 1 to 5 in preterm neonates alongside decrease of Ht |
| Genzel-Boroviczeny et al. (41) | OPS | Anemic preterm neonates receiving blood transfusion | 13 | Cutaneous (upper inner arm) | FVD increased after blood transfusion; other microcirculatory or macrocirculatory parameters were unaltered |
| Kroth et al. (42) | OPS | Healthy preterm neonates | 25 | Cutaneous (upper inner arm) | FVD decreased from week 1 to 4 and was correlated with Hb and incubator temperatures; VD and RBC velocities did not change over time |
| Weidlich et al. (43) | OPS | Preterm neonates: proven infection vs. suspected but unproven infection | 17/9 | Cutaneous (upper inner arm) | FVD varied widely, infection group showed 10% decline 5 days before AB compared to controls (intra-individual differences) |
| Top et al. (11) | OPS | Term neonates with severe respiratory failure: VA ECMO vs. controls | 14/10 | Buccal mucosa | FVD of ECMO patients was lower before start ECMO than of controls; FVD improved after ECMO |
| Hiedl et al. (44) | SDF | Preterm neonates: significant PDA vs. non-significant PDA | 13/12 | Cutaneous (upper inner arm) | Group with significant PDA showed lower FVD and higher number of small vessels; after treatment groups did not differ |
| Top et al. (45) | OPS | Healthy term neonates vs. 1 to 6 month olds vs. 3 year olds | 22/19/4 | Buccal mucosa | FVD was highest in first week of life; after first week no correlation between FVD and age |
| Ergenekon et al. (46) | SDF | Neonates with polycythemia requiring partial exchange transfusion | 15 | Cutaneous (axilla) | After transfusion MFI and number of vessels with hyperdynamic flow increased from baseline values |
| Top et al. (47) | OPS | Term neonates with severe respiratory failure: VA ECMO vs. controls | 21/7 | Buccal mucosa | FVD is preserved after start ECMO, while FVD deteriorated in ventilated controls |
| Alba-Alejandre et al. (48) | OPS | Term neonates: mild/moderate infection vs. controls | 16/31 | Cutaneous (ear conch) | Infection group showed lower PPV with continuous flow than controls |
| Schwepcke et al. (49) | SDF | Preterm neonates: postnatal hypertension vs. controls | 10/11 | Cutaneous (upper inner arm) | Preterm neonates with hypotension showed higher FVD in the first 6 h after birth; at 12 h after birth both blood pressure and FVD did not differ between groups |
| Tytgat et al. (12) | SDF | Neonates undergoing laparoscopic surgery for hypertrophic pyloric stenosis | 12 | Buccal and sublingual mucosa | Buccal FVD did not differ before and after surgery. Sublingual blood vessel diameters increased during CO2 insufflation and decreased after CO2 exsufflation |
| Ergenekon et al. (50) | SDF | Term neonates with HIE: TH vs. controls | 7/7 | Cutaneous (axilla) | Patients showed lower MFI and more vessels with sluggish flow than controls. After TH parameters recovered to values of controls |
| Buijs et al. (6) | SDF | Term neonates with CDH: catecholamines vs. controls | 28/28 | Buccal mucosa | Catecholamines improved the macrocirculation, but did not alter the microcirculation; impaired microcirculation was predictive of outcome |
| Van den Berg et al. (35) | SDF | Healthy term neonates | 28 | Cutaneous (upper inner arm)/buccal mucosa | Application SDF imaging; reproducibility of buccal PVD with SDF imaging was confirmed, cutaneous PVD showed poor reproducibility |
| Van Elteren et al. (17) | SDF/IDF | Healthy preterm neonates | 20 | Cutaneous (upper inner arm) | IDF imaging showed higher TVD and lower PPV values than SDF imaging because of higher image quality |
| Van Elteren et al. (51) | IDF | Healthy preterm vs. term neonates | 60/33 | Cutaneous (upper inner arm) | TVD decreased in first month of life in both groups; TVD was higher in preterm than in term neonates |
| Gassmann et al. (52) | IDF | Healthy term neonates: born at high altitude vs. born at sea level | 53/33 | Cutaneous (upper inner arm) | TVD was higher in neonates born at high altitude (lower SpO2 levels) than in neonates born at sea level |
| Wright et al. (36) | SDF | Healthy term neonates | 42 | Cutaneous (ear conch) | Application SDF imaging; reporting of reference values for microcirculatory parameters for ear conch |
| Kulali et al. (53) | SDF | Healthy term neonates: vaginal delivery vs. cesarean section | 12/25 | Cutaneous (axilla) | Vaginal delivery group showed more vessels with hyperdynamic flow than cesarean section group; other parameters did not differ between groups |
| Puchwein-Schwepcke et al. (54) | SDF | Term neonates: infection treated with antibiotics vs. controls | 13/95 | Cutaneous (ear conch) | Infection group showed lower FVD and higher proportion of hyperdynamic flow than control group; hyperdynamic flow was associated with 5-fold increased risk for infection |
| Puchwein-Schwepcke et al. (55) | SDF | Preterm neonates with extreme LBW: hypercapnia vs. controls (sub-analysis RCT) | 6/6 | Cutaneous (upper inner arm) | Hypercapnia group showed lower FVD and relatively fewer small vessels than controls |
Summary of findings: microcirculatory studies performed in neonates.
BP, blood pressure; CDH, congenital diaphragmatic hernia; ECMO, extracorporeal membrane oxygenation; etCO2, end tidal carbon dioxide; FVD, functional vascular density; GA, gestational age; Hb, hemoglobin; HIE, hypoxic ischemic encephalopathy; HR, heart rate; Ht, hematocrit; HVM, handheld vital microscopy; IDF, incident dark field illumination; LBW, low birth weight; OPS, orthogonal polarization spectral; PDA, persistent ductus arteriosus; PPV, perfused vessel density (%); RBC, red blood cell; SDF, sidestream dark field; TH, therapeutic hypothermia; TVD, total vessel density; VA ECMO, veno-arterial extracorporeal membrane oxygenation; VD, vessel diameter.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Summary
Keywords
microcirculation, hemodynamic monitoring, neonates, pediatrics, critical care
Citation
Erdem Ö, Ince C, Tibboel D and Kuiper JW (2019) Corrigendum: Assessing the Microcirculation With Handheld Vital Microscopy in Critically lll Neonates and Children: Evolution of the Technique and Its Potential for Critical Care. Front. Pediatr. 7:346. doi: 10.3389/fped.2019.00346
Received
01 August 2019
Accepted
02 August 2019
Published
21 August 2019
Approved by
Frontiers Editorial Office, Frontiers Media SA, Switzerland
Volume
7 - 2019
Updates
Copyright
© 2019 Erdem, Ince, Tibboel and Kuiper.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Jan Willem Kuiper j.kuiper@erasmusmc.nl
This article was submitted to Pediatric Critical Care, a section of the journal Frontiers in Pediatrics
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