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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Chem. | doi: 10.3389/fchem.2019.00770

Antifouling and pH-responsive poly(carboxybetaine)-based nanoparticles for tumor cell targeting

 Jiwei Cui1*, Feng Ding1, Shuang Yang1, Zhiliang Gao1,  Jianman Guo1,  Peiyu Zhang1,  Xiaoyong Qiu1,  Qiang Li1,  Mingdong Dong1, Jingcheng Hao1 and  Qun Yu1
  • 1Shandong University, China

Nanocarriers with responsibility and surface functionality of targeting molecules have been widely used to improve therapeutic efficiency. Hence, we report the assembly of pH-responsive and targeted polymer nanoparticles (NPs) composed of poly(2-(diisopropylamino)ethyl methacrylate) (PDPA) as the core and poly(carboxybetaine methacrylate) (PCBMA) as the shell, functionalized with cyclic peptides containing Arginine-Glycine-Aspartic acid-D-Phenylalanine-Lysine (RGD). The resulted polymer NPs (PDPA@PCBMA-RGD NPs) can maintain the pH-responsivity of PDPA (pKa ~6.5) and low-fouling property of PCBMA that significantly resist nonspecific interactions with RAW 264.7 and HeLa cells. Meanwhile, PDPA@PCBMA-RGD NPs could specifically target to αvβ3 integrin-expressed human glioblastoma (U87) cells. The pH-responsiveness and low fouling properties of PDPA@PCBMA NPs is comparable to PDPA@poly(ethylene glycol) (PDPA@PEG) NPs, which indicates that PCBMA is an alternative of PEG for low-fouling coatings. The advantage of PDPA@PCBMA NPs lies in the presence of carboxyl groups on their surfaces for further modification (e.g., RGD functionalization for cell targeting). The reported polymer NPs represents a new carrier that have the potential for targeted therapeutic delivery.

Keywords: Poly(carboxybetaine methacrylate), PEG, PH-responsiveness, low-fouling, Cell targeting

Received: 28 Aug 2019; Accepted: 24 Oct 2019.

Copyright: © 2019 Cui, Ding, Yang, Gao, Guo, Zhang, Qiu, Li, Dong, Hao and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Jiwei Cui, Shandong University, Jinan, China,