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Review ARTICLE

Front. Chem. | doi: 10.3389/fchem.2020.00751

Rationally Designed DNA Nanostructures for Drug Delivery Provisionally accepted The final, formatted version of the article will be published soon. Notify me

 Fan Xu1, Qing Xia1 and  Pengfei Wang1*
  • 1School of Medicine, Shanghai Jiao Tong University, China

DNA is an excellent biological material that gets emerging attention in the field of nanotechnology due to its unique capability for precisely engineering materials via sequence specific interactions. Self-assembled DNA nanostructures of prescribed physicochemical properties have demonstrated potent drug delivery efficiency in vitro and in vivo. By using bioconjugation techniques, DNA nanostructures can be precisely integrated with various functional moieties such as targeting ligands, proteins, inorganic nanoparticles etc. to enrich their functionalities and to enhance their performance. In this review, we begin with strategies on constructing DNA nanostructures. Further, we summarize the biological barriers ahead of drug delivery using DNA nanostructures followed by introducing existing rational solutions to overcome these biological barriers. Lastly, we discuss challenges and opportunities for DNA nanostructures towards real applications in clinical settings.

Keywords: drug deliver systems, DNA self assembly, nanocarrier, Biological barrier, rational design

Received: 12 Jun 2020; Accepted: 21 Jul 2020.

Copyright: © 2020 Xu, Xia and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Pengfei Wang, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, Shanghai Municipality, China, pengfei.wang@sjtu.edu.cn