Applications of Raman spectroscopy in ocular biofluid detection Provisionally Accepted
Zhijun Guo- 1Beijing Institute of Petrochemical Technology, China
Ophthalmic and many systemic diseases may damage the eyes, resulting in changes in the composition and content of biomolecules in ocular biofluids such as aqueous humor and tear. Therefore, the biomolecules in biofluids are potential biomarkers to reveal pathological processes and diagnose diseases. Raman spectroscopy is a non-invasive, label-free, and cost-effective technique to provide chemical bond information of biomolecules and shows great potential in the detection of ocular biofluids. This review demonstrates the applications of Raman spectroscopy technology in detecting biochemical components in aqueous humor and tear, then summarizes the current problems encountered for clinical applications of Raman spectroscopy and looks forward to possible approaches to overcome technical bottlenecks. This work may provide a reference for wider applications of Raman spectroscopy in biofluid detection and inspire new ideas for the diagnosis of diseases using ocular biofluids.
Keywords: Aqueous Humor, biomolecules, ocular biofluids, Raman spectroscopy, tear
Received: 27 Mar 2024;
Accepted: 20 May 2024.
Copyright: © 2024 Guo, Ma, Lu, Ma, Yu and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Mx. Miaoli Ma, Beijing Institute of Petrochemical Technology, Beijing, China
Prof. Qianjin Guo, Beijing Institute of Petrochemical Technology, Beijing, China