The first 1,000 days of life are crucial in the growth and development of infants, as they have a diet of limited variability, mainly consisting of breastmilk and/or infant formula, followed by the introduction of milk and solid foods. The composition of all these foods significantly affects immune response and development, also affecting immunity later in life. Essentially, all dietary antigens are proteins that may prevent or contribute to the development of allergies.
In vitro and in vivo studies, especially in nutrition, increasingly require attention since they allow the identification and investigation of different and new treatments for allergic disorders. Accordingly, the notion that the composition and metabolic activity of foods and the role of intestinal microbiota in the development of allergies have become clearer over the last few years, and there is an urgent need to provide information on this issue.
The potential effects of vitamin D supplementation on airway obstruction may be through inflammatory cytokine changes, which are evident in T2-low asthma. In asthma, Zhou et al. first reported both in vivo and human models, outlining the associations between vitamin D levels and airway inflammation, airway resistance, and small-airway function (1). Similarly, supplementation with pomegranate, thanks to its anti-inflammatory properties, was significantly associated with an improvement in forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity (FVC) ratio (FEV1/FVC), and forced expiratory flow of 25–75% (FEF25–75%) in patients with mild and moderate allergic asthma (Shateri et al.). On the contrary, an increase in markers reflecting a pro-inflammatory immune response, such as High-density lipoprotein-cholesterol (HDL), folate, iron, and eosinophil levels, were independently and inversely associated with the immunological status of asthmatic adults (Wen, Zhuang et al.; Wen, Wang, Giri et al.; Wen, Wang, Xia et al.).
Globally, we urgently require an overview of best practices for biospecimen collection and analyses, as well as studies on the fundamentals of clinical data management (preparation and study startup including data collection, entry, cleaning, and authentication), and databases focusing on nutritional issues.
Statements
Author contributions
SM: Conceptualization, Supervision, Validation, Visualization, Writing—original draft. FG: Visualization, Writing—review & editing. SL: Conceptualization, Supervision, Validation, Visualization, Writing—review & editing.
Funding
The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
Publisher’s note
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References
1.
Parisi GF Carota G Castruccio Castracani C Spampinato M Manti S Papale M et al . Nutraceuticals in the prevention of viral infections, including COVID-19, among the pediatric population: a review of the literature. Int J Mol Sci. (2021) 22:2465. 10.3390/ijms22052465
Summary
Keywords
children, adults, allergic diseases, clinical outcomes, nutrition, immune system, diagnosis
Citation
Manti S, Galletta F and Leonardi S (2024) Editorial: Nutrition, diet and allergic diseases. Front. Nutr. 10:1359005. doi: 10.3389/fnut.2023.1359005
Received
20 December 2023
Accepted
27 December 2023
Published
11 January 2024
Volume
10 - 2023
Edited and reviewed by
Willem Van Eden, Utrecht University, Netherlands
Updates
Copyright
© 2024 Manti, Galletta and Leonardi.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Sara Manti smanti@unime.it
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.