Abstract
Left posterior fascicular ventricular tachycardia (LPFVT) is extremely rare in neonates. We described a 17-day-old girl with LPFVT who was initially misdiagnosed as supraventricular tachycardia (SVT). Eventually, she was successfully treated by amiodarone infusion followed by oral amiodarone with propranolol for 9 months, and LPFVT spontaneously resolved after a 1-year follow-up. This case report illustrated the basic principles and caveats in differential diagnosis of LPFVT in the neonatal age group. With proper diagnosis and therapy, neonatal LPFVT might regress in the first year of life.
Introduction
Left posterior fascicular ventricular tachycardia (LPFVT) is extremely rare in newborns. To the best of our knowledge, only three neonatal cases have been reported in the literature since LPFVT was firstly described by Belhassen et al. in 1981 (1–4). LPFVT is frequently misdiagnosed as supraventricular tachycardia (SVT) in clinical practice because the QRS duration is slightly prolonged during tachycardia, particularly in infants. In this case report, we described a 17-day-old girl with recurrent LPFVT, focusing on the electrocardiogram (ECG) recognition, management, and prognosis of this type of arrhythmia in neonatal age group.
Case Presentation
A premature female newborn was delivered at a gestational age of 35+4 weeks in a local hospital, with birth weight of 2,410 g. She was transferred to NICU in our institution. On the 17th day after birth, tachycardia was identified by the monitor. A 12-lead electrocardiogram (ECG) demonstrated a regular tachycardia with a heart rate of 210 beats per minute (bpm), a slightly wide QRS duration of 72 ms, a superior QRS axis of 223°, and a right bundle branch block pattern (RBBB) (Figure 1). She was initially presumed to have SVT. The echocardiography showed a structurally normal heart with a patent foramen ovale and normal cardiac function. Ice dunking followed by three boluses of adenosine triphosphate (ATP) injection to a maximum dose of 0.5 mg/kg was unsuccessful in terminating the tachycardia. Thereafter, electrical cardioversion was tried and failed to revert the rhythm to sinus. She remained hemodynamically stable, and intravenous amiodarone infusion at a full dose of 15 mcg/kg/min was started. During continuous amiodarone infusion, ECG revealed atrioventricular (AV) dissociation, occasional capture beats, and fusion beats (Figure 2). The sinus rhythm with normal AV conduction and narrow QRS duration of 62 ms was achieved 6 h later (Figure 3). By then, a diagnosis of LPFVT was established by reviewing all ECG strips. Non-sustained tachycardia recurred when intravenous amiodarone was gradually weaned off. The patient was discharged on oral amiodarone (5 mg/kg/day) with propranolol (2 mg/kg/day), despite that non-sustained episodes of LPFVT were documented by Holter. At 2 months of age, the girl was admitted to the emergency room for sustained LPFVT over 1 h. Tachycardia was successfully terminated by electrical cardioversion, and the medication dose for prophylaxis arrhythmia was increased proportionally to her weight increment. She was closely followed up by Holter every 4–8 weeks, and there was no recurrence of LPFVT after 6 months. Anti-arrhythmia medications were discontinued at 9 months. Her liver function and thyroid function were assessed every 3 months prior to discontinuation of medication and were within the normal range. Her last Holter evaluation at 13 months of age was completely normal. The timeline of diagnosis and therapy of LPFVT in this neonatal case are set out in Table 1.
Figure 1
Figure 2
Figure 3
Table 1
| Age | Event | Management |
|---|---|---|
| Day 0 | Premature delivery | Transferred to our institution |
| Day 17 | Tachycardia | Diagnosis of SVT was presumed Ice dunking, ATP injection, and electrical cardioversion failed to terminate tachycardia Intravenous amiodarone was started |
| Day 18 | Termination of sustained tachycardia | ECG revealed AV dissociation, capture beats and fusion beats. Diagnosis was revised to LPFVT |
| Day 18–33 | Non-sustained tachycardia | Gradual withdrawal of amiodarone infusion |
| Day 33 | Non-sustained tachycardia | Oral propranolol (2 mg/kg/d) and amiodarone (5 mg/kg/d) were started |
| Day 42 | Non-sustained tachycardia | Discharged |
| 2 months | Sustained tachycardia over 1 hour | Electric cardioversion reverted LPFVT to sinus rhythm Increased dose of propranolol (2 mg/kg/d) and amiodarone (5 mg/kg/d) proportionally to her weight increment |
| 3–5 months | Non-sustained tachycardia | Holter followed up every 4–8 weeks |
| 6 months | Sinus rhythm | Oral propranolol and amiodarone continued |
| 9 months | Sinus rhythm | Oral propranolol and amiodarone discontinued |
| 13 months | Sinus rhythm | Last Holter followed up |
The timeline of patient diagnosis and therapy.
SVT, supraventricular tachycardia; ATP, adenosine triphosphate; ECG, electrocardiogram; AV, atrioventricular; LPFVT, left posterior fascicular ventricular tachycardia.
Discussion
Fascicular ventricular tachycardia (VT) is a form of idiopathic and Purkinje-related arrhythmia and is rarely reported in newborns. LPFVT is the most common form of fascicular VT, originating in the left posterior fascicle (5, 6).
The typical ECG pattern of LPFVT is characterized by right bundle branch block and superior axis deviation. The QRS morphology is mildly widened during tachycardia. It is often misdiagnosed as SVT with RBBB and left anterior hemiblock aberrancy. In the published literatures, the initial misdiagnosis rate of LPFVT in young infants is as high as 40% (2–4, 7–11). Therefore, we would like to demonstrate the basic principles and caveats in differential diagnosis of LPFVT in the neonatal age group by reviewing the present case. Firstly, VT in neonates is rare but does occur. It is important to bear in mind that the upper limit of normal QRS duration is 65 ms in neonates (12). In the present case, QRS duration during tachycardia was 72 ms, which exceeded the normal range. The diagnosis of VT should therefore be assumed. Secondly, AV dissociation, capture beats, and fusion beats during tachycardia are diagnostic markers of VT, but these studies are not usually present in neonates due to the rapid ventricular rate and presence of ventriculoatrial (VA) retrograde conduction. In reviewing the initial ECG strip of this case, the reverse P′ wave during VT was recognized, which indicated VA retrograde conduction. AV dissociation, capture beats, and fusion beats were identified during amiodarone infusion. Thirdly, LPFVT does not respond to adenosine (2, 8, 13), while other types of wide QRS tachycardia, which need to be differentiated from VT, including SVT with bundle branch block and SVT with anterograde conduction across an accessory pathway, can usually be terminated by adenosine. Thus, if adenosine injection is not effective in reverting presumed SVT, possibility of LPFVT should be considered.
The experience in management of infantile LPFVT is very limited. Verapamil is most commonly used in older children and has been shown to terminate tachycardia in 93% of children with LPFVT (13). However, its use in infants is widely considered to be contraindicated due to the risk of hemodynamic collapse (14). Beta blockers, amiodarone, and electrical cardioversion are usually recommended. Electrical cardioversion could achieve termination of LPFVT in 62% of children, and the effective rate of amiodarone infusion is not clearly known (13–15). In our neonatal case, LPFVT did not respond to electrical cardioversion, while it was reverted to sinus rhythm by amiodarone infusion. Oral amiodarone with propranolol had been given for 9 months to prevent recurrence until LPFVT regressed. Verapamil has recently been used for arrhythmia in infants (2, 16, 17). Slow intravenous infusion at a dose of 0.1 mg/kg over at least 10 min appeared to be safe and efficient in terminating infantile LPFVT, but only one newborn was enrolled (2, 7, 9, 11).
LPFVT is often considered to be a type of idiopathic VT with good prognosis, but delayed diagnosis and therapy can result in severe cardiac dysfunction (8). The eventual resolution of LPFVT in our neonatal case is consistent with the previous report by Collins et al., which showed that LPFVT occurring in the first year of life may resolve spontaneously (13).
Conclusion
This illustrative case report describes a neonate with LPFVT that was initially misdiagnosed as supraventricular tachycardia. The clinical course highlights the caveats of differential diagnosis in neonatal ECG evaluation and the favorable outcome of LPFVT. With proper diagnosis and treatment, LPFVT may regress over time within the first year of life.
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Written informed consent was obtained from the minor(s)' legal guardian/next of kin for the publication of any potentially identifiable images or data included in this article.
Author contributions
All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.
Acknowledgments
We are grateful to Thomas Yang from The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA, who helped us edit and polish the English grammar for this article.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Summary
Keywords
neonate, infant, arrhythmia, tachycardia, fascicular ventricular tachycardia
Citation
Zhao L, Wu L, Zhao Q and Liang X (2021) Case Report: Recurrent Left Posterior Fascicular Ventricular Tachycardia in a Newborn. Front. Pediatr. 9:691146. doi: 10.3389/fped.2021.691146
Received
05 April 2021
Accepted
05 July 2021
Published
05 August 2021
Volume
9 - 2021
Edited by
Anne Lee Solevåg, Oslo University Hospital, Norway
Reviewed by
Stefan Kurath-Koller, Medical University of Graz, Austria; Seung Yeon Kim, Eulji University, South Korea
Updates
Copyright
© 2021 Zhao, Wu, Zhao and Liang.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Lin Wu wulin0609@foxmail.com
This article was submitted to Neonatology, a section of the journal Frontiers in Pediatrics
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.