Frontiers in Aging Neuroscience

Original Research

Published on 20 Aug 2025

Age-related trajectories of quality of life in community dwelling older adults: findings from the Survey of Health, Aging and Retirement in Europe (SHARE)

Sarah Mendorf
Konstantin G. Heimrich
Hannah M. Mühlhammer
Tino Prell
Aline Schönenberg

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1632607

3,085 views
2 citations

Original Research

Published on 20 Aug 2025

Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer’s disease

Alexander Erofeev
Egor Vinokurov
Anastasia Bol’shakova
Ilya Bezprozvanny
Olga Vlasova

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1550673

2,587 views

Original Research

Published on 20 Aug 2025

Effectiveness of computer-assisted cognitive training on cognitive function and activities of daily living in patients with post-stroke cognitive impairment

Xiaoyang Feng
Xiaolin Sun
Jia Liu
Yan Li
Yunhai Yao
Jianming Fu
Xudong Gu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1590783

2,517 views

Original Research

Published on 20 Aug 2025

Virtual reality navigation for the early detection of Alzheimer’s disease

Sayuri Shima
Reiko Ohdake
Yasuaki Mizutani
Harutsugu Tatebe
Riki Koike
Atsushi Kasai
Epifanio Bagarinao
Kazuya Kawabata
Akihiro Ueda
Mizuki Ito

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1571429

3,748 views
1 citation

Systematic Review

Published on 19 Aug 2025

Traditional Chinese exercises for motor symptoms and mobility in patients with Parkinson's disease: a systematic review and meta-analysis

Fumei Yuan
Hong Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1612913

2,571 views
1 citation

Editorial

Published on 19 Aug 2025

Editorial: The open challenges of cognitive frailty: risk factors, neuropsychological profiles and psychometric assessment for healthy aging

Simone Varrasi
Sabrina Castellano
Daniele Magistro

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1679406

1,534 views
1 citation

Brief Research Report

Published on 19 Aug 2025

Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging

Viana Q. Pham
Melike Tutunculer
Halah Al-Dulaimi
Daniel Ardjmand
William Fleischmann
Tomas P. Bachor
Allison W. Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1634283

3,082 views

Original Research

Published on 18 Aug 2025

Risk prediction of recurrent ischemic stroke based on Carotid Plaque-RADS: construction and validation of a nomogram model

Miao Qiao
Ting Zhou
Rui Wang
Yanhui Jiang
Huitao Liang
Lingcui Meng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1646916

2,975 views
4 citations

Systematic Review

Published on 18 Aug 2025

Glutamate-associated research in Parkinson’s disease: a bibliometric analysis

Yan-Jun Chen
Ming-Rong Xie
Sheng-Qiang Zhou
Fang Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1569924

3,115 views

Original Research

Published on 18 Aug 2025

Accelerated midlife endocrine and bioenergetic brain aging in APOE4 females

Tian Wang
Zisu Mao
Yuan Shang
Simona Merlini
Francesca Vitali
Jean-Paul Wiegand
Roberta Diaz Brinton

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1632877

4,305 views
2 citations

Original Research

Published on 18 Aug 2025

Age-related differences in the weighting of kinematic and contextual information during action prediction

Elisa Ravizzotti
Alessandra Finisguerra
Gaia Bonassi
Carola Cosentino
Susanna Mezzarobba
Alessandro Botta
Martina Putzolu
Sara Terranova
Valentina Bianco
Laura Avanzino

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1622569

1,701 views
1 citation

Original Research

Published on 18 Aug 2025

Accurate and robust prediction of Amyloid-β brain deposition from plasma biomarkers and clinical information using machine learning

Jiayuan Xu
Andrew J. Doig
Sofia Michopoulou
Petroula Proitsi
Fumie Costen
The Alzheimer's disease neuroimaging initiative

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1559459

2,347 views

Review

Published on 15 Aug 2025

Naringenin as a neurotherapeutic agent in Alzheimer’s disease: epigenetic signatures, gut microbiota alterations, and molecular neuroprotection

Zhenzhen Lai
Long Ke
Wei Zhao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1647967

4,857 views
7 citations

Review

Published on 15 Aug 2025

Artificial intelligence technologies for enhancing neurofunctionalities: a comprehensive review with applications in Alzheimer’s disease research

Zhirong Gu
Bin Ge
Yuanyuan Wang
Yiping Gong
Mei Qi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1609063

4,784 views
2 citations

Mini Review

Published on 14 Aug 2025

Exploring efficient and effective mammalian models for Alzheimer’s disease

Mitsunori Kayano

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1652754

3,367 views
1 citation

Original Research

Published on 14 Aug 2025

Neurofilament light chain concentration mediates the association between regional cortical thickness and Parkinson’s disease with excessive daytime sleepiness

Jieyu Chen
Guoliang Jiang
Yongyun Zhu
Chunyu Liang
Chenxi Liu
Jianzhun Chen
Baiyuan Yang
Xinglong Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1645290

1,711 views
1 citation

Original Research

Published on 13 Aug 2025

Age- and sex-related differences in landmark recall following a virtual spatial navigation task

Alexis N. Chargo
Cheryl L. Dahle
Naftali Raz
Ana M. Daugherty

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1602945

1,689 views

Original Research

Published on 13 Aug 2025

Combinations of multimodal neuroimaging biomarkers and cognitive test scores to identify patients with cognitive impairment

Yuriko Nakaoku
Soshiro Ogata
Kiyotaka Nemoto
Chikage Kakuta
Eri Kiyoshige
Kanako Teramoto
Kiyomasa Nakatsuka
Gantsetseg Ganbaatar
Masafumi Ihara
Kunihiro Nishimura

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1650629

2,323 views

Original Research

Published on 13 Aug 2025

Gut dysbiosis is associated with increased blood–brain barrier permeability and cognitive impairment in elderlies with coronary heart disease

Lichao Di
Peiying Huang
Yeju He
Na Sun
Liwei Chi
Lining Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1640761

2,911 views
3 citations

Systematic Review

Published on 13 Aug 2025

The effect of transcranial direct current stimulation on static and dynamic posture control in the elderly: a systematic review and meta-analysis

Yaru Wei
Peng Chen
Jianglong Zhan
Lulu Yin
Zhongqi Yu
Lin Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1645962

2,313 views

Perspective

Published on 12 Aug 2025

A model to address healthcare gaps and poor research participation in Hispanic patients with Parkinson's disease

M. Felice Ghilardi
Alessandro Di Rocco
Jennifer Fearday
Donna Sperlakis
Maria Lima
Nora Vanegas-Arroyave
Elisa Tatti
Marcelo Arroyave
Evelyn Stevens
Denise Hernandez

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1610448

1,945 views

Original Research

Published on 12 Aug 2025

Relationship between the platelet-to-lymphocyte ratio and in-hospital mortality of ischemic stroke patients in the intensive care unit

Guohua Liu
Ya Zhou
Hao Ding
Lin Chen
Lan Chen
Sufang Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1607332

2,018 views

Original Research

Published on 12 Aug 2025

Local gyrification index and sulcal depth as imaging markers of cognitive decline in Alzheimer’s disease

Yongsik Sim
Changmin Seo
Young-gun Lee
Byoung Seok Ye
Ilwoo Lyu
Beomseok Sohn

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1635861

2,308 views

Mini Review

Published on 12 Aug 2025

Seeking the neural basis of neuropsychiatric symptoms in dementia: neuroimaging findings and controversies

Daichi Sone
Shunichiro Shinagawa

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1633309

1,978 views
1 citation

7,815 Publications

volumes

Volume 17 - 2025

Age-related trajectories of quality of life in community dwelling older adults: findings from the Survey of Health, Aging and Retirement in Europe (SHARE)

Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer’s disease

Effectiveness of computer-assisted cognitive training on cognitive function and activities of daily living in patients with post-stroke cognitive impairment

Virtual reality navigation for the early detection of Alzheimer’s disease

Traditional Chinese exercises for motor symptoms and mobility in patients with Parkinson's disease: a systematic review and meta-analysis

Editorial: The open challenges of cognitive frailty: risk factors, neuropsychological profiles and psychometric assessment for healthy aging

Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging

Risk prediction of recurrent ischemic stroke based on Carotid Plaque-RADS: construction and validation of a nomogram model

Glutamate-associated research in Parkinson’s disease: a bibliometric analysis

Accelerated midlife endocrine and bioenergetic brain aging in APOE4 females

Age-related differences in the weighting of kinematic and contextual information during action prediction

Accurate and robust prediction of Amyloid-β brain deposition from plasma biomarkers and clinical information using machine learning

Naringenin as a neurotherapeutic agent in Alzheimer’s disease: epigenetic signatures, gut microbiota alterations, and molecular neuroprotection

Artificial intelligence technologies for enhancing neurofunctionalities: a comprehensive review with applications in Alzheimer’s disease research

Exploring efficient and effective mammalian models for Alzheimer’s disease

Neurofilament light chain concentration mediates the association between regional cortical thickness and Parkinson’s disease with excessive daytime sleepiness

Age- and sex-related differences in landmark recall following a virtual spatial navigation task

Combinations of multimodal neuroimaging biomarkers and cognitive test scores to identify patients with cognitive impairment

Gut dysbiosis is associated with increased blood–brain barrier permeability and cognitive impairment in elderlies with coronary heart disease

The effect of transcranial direct current stimulation on static and dynamic posture control in the elderly: a systematic review and meta-analysis

A model to address healthcare gaps and poor research participation in Hispanic patients with Parkinson's disease

Relationship between the platelet-to-lymphocyte ratio and in-hospital mortality of ischemic stroke patients in the intensive care unit

Local gyrification index and sulcal depth as imaging markers of cognitive decline in Alzheimer’s disease

Seeking the neural basis of neuropsychiatric symptoms in dementia: neuroimaging findings and controversies