Frontiers in Cellular and Infection Microbiology

Original Research

Published on 05 Jun 2026

Vaxjo 2.0: An ontology- and large language model-powered knowledge base of vaccine adjuvants and mechanisms

in Microbial Vaccines

Joshua Monickaraj
Hasin Rehana
Ani Bernardi
Yuping Zheng
Taiyu Lin
Le Liu
Amogh Madireddi
Leo Yeh
Jie Zheng
Junguk Hur

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2026.1763384

859 views

Original Research

Published on 05 Jun 2026

In silico design of a multiantigenic and multiepitope chimeric protein as a vaccine candidate against Renibacterium salmoninarum

in Microbial Vaccines

Jeffrey Araneda
Patricio A. Flores-Herrera
Waldo Acevedo
Sergio H. Marshall
Fernando A. Gómez

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2026.1814020

725 views

Original Research

Published on 01 Jun 2026

Engineering low-endotoxin lipid A in a double auxotroph Pseudomonas aeruginosa to develop safer whole-cell vaccines

in Microbial Vaccines

Víctor Fuentes-Valverde
Patricia García
Ana Candela
Rebeca Santamarina-Fernández
José Avendaño-Ortiz
Emma Martínez-Alonso
Marina Oviaño
Rafael Cantón
Jesús Arenas
Miriam Moscoso

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2026.1840122

516 views

Editorial

Accepted on 31 May 2026

Editorial: Exploring the Interface of Mucosal Vaccines and Immune System Modulation

in Microbial Vaccines

Jinyi Tang
Arka Sen Chaudhuri
Bibo Zhu

Frontiers in Cellular and Infection Microbiology

125 views

Original Research

Accepted on 29 May 2026

STING agonist 2'3'-cGAMP as an effective adjuvant for HPV16 peptide vaccine enhances anti-tumor immunity in TC-1 Mice models

in Microbial Vaccines

Yina Cun
Rui Yang
Jie Dai
XinWen Zhang
Lili Zhou
Li Shi
Jing Li
Haocheng He
Shuyuan Liu
Yufeng Yao

Frontiers in Cellular and Infection Microbiology

192 views

Original Research

Published on 29 May 2026

In silico design and testing of a multi-epitope camel mastitis vaccine candidate for development

in Microbial Vaccines

Edwin Murungi
Nathan Langat
Ednah Masila
Ruth Onywera
Irene Ogali
Nimmo Gicheru
Hezron Wesonga
Monicah Maichomo

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2026.1753101

496 views

Review

Accepted on 28 May 2026

Artificial Intelligence in Vaccine Development: Applications, Implementation, and Future Directions

in Microbial Vaccines

Sastha Kumar N
Raj Gondane
Shubham Mahindrakar
Sukrut Vyawahare
Renju Krishna
Sabarinath Subramaniam
Bipin Nair
Geetha Kumar
Aravind Madhavan
Nidheesh M

Frontiers in Cellular and Infection Microbiology

218 views

Original Research

Published on 22 May 2026

Repeated dose toxicity and immunogenicity studies in SD rats: a new recombinant zoster vaccine (CHO cell) formulated with adjuvant BC02

in Microbial Vaccines

Qian Yang
Luxi Yang
Aihua Zhao
Lingyun Ge
Fang Liu
Zhengbiao Yang
Yue Huang
Qiuhong Jiang
Yaru Deng
Xuehan Hu

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2026.1756776

619 views

Original Research

Published on 30 Mar 2026

A needle-free intradermal PEDV S protein vaccine elicits protective lactogenic immunity in piglets

in Microbial Vaccines

Shengjin Liu
Rui Geng
Lu Wang
Xiaona Wei
Yongchang Cao
Hanqin Shen
Feng Chen

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2026.1720440

1,344 views

Systematic Review

Published on 13 Mar 2026

Two decades of global research on tetanus vaccines and tetanus immunoglobulins: a comprehensive bibliometric analysis and integrative review (2000–2025)

in Microbial Vaccines

Chaoxi Zhou
Yongbo Zuo
Jianhua Ma
Zhilin Liang
Chuanyi Zang

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2026.1766140

2,023 views

Original Research

Published on 09 Feb 2026

A computational pipeline to discover potential cross-reactive antibodies: a case study on coronavirus

in Microbial Vaccines

Li Ye
Mengdie Hu
Yuan Wang
Zihao Li
Yewei Cun
Kailin Tang
Zhiwei Cao

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2026.1692727

1,387 views

Original Research

Published on 02 Feb 2026

Diphtheria-tetanus-acellular pertussis vaccine safety in children under 7 years: a post-marketing analysis of the U.S. vaccine adverse event reporting system

in Microbial Vaccines

Meishen Liu
Xueying Zhou
Linshu Guan
Hening Sun
Zhaohui Bai
Yalin Xi
Xinkuo Zheng

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2026.1733777

2,733 views

Original Research

Published on 27 Jan 2026

Risk signal assessment of Tdap vaccine use alone by pregnant women: An updated pharmacoepidemiological study

in Microbial Vaccines

Rujuan Fan
Zhijuan Zhu
Xiangyu Li
Lingjing Yuan

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1689560

3,004 views

Original Research

Published on 07 Jan 2026

High-throughput identification of immunoreactive peptides and corresponding proteins from Anaplasma platys and Ehrlichia canis using peptide microarray chips

in Microbial Vaccines

Alejandro Llanes
Swetha Madesh
Kalvis Brangulis
Sreekumari Rajeev

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1671309

1,518 views

Review

Published on 07 Jan 2026

Ex vivo mucosal cultures: an emerging player in vaccine development

in Microbial Vaccines

Nikita Chilakamarri
Erwan Sallard
Malik Aydin

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1739617

2,587 views

Original Research

Published on 17 Dec 2025

Evaluation of the protective efficacy of a recombinant adenovirus-vectored SARS-CoV-2 vaccine candidate for veterinary use

in Microbial Vaccines

Chong Wang
Zhiyuan Wen
Gongxun Zhong
Lei Shuai
Chen Wang
Qilong Liu
Chenyu Ren
Jinying Ge
Xijun Wang
Jinliang Wang

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1714427

2,362 views

Original Research

Published on 28 Nov 2025

Differential antioxidant enzyme profiles reveal early molecular signatures of virulence in Trypanosoma cruzi DTU-TcI and DTU-TcVI strains

in Microbial Vaccines

Edward Valencia Ayala
João Reis Cunha
Maritza Calderón Sánchez
Angela Giovanna Vidal Riva
Daniella Castanheira Bartholomeu
Alexandre Ferreira Marques

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1664827

2,213 views

Editorial

Published on 19 Nov 2025

Editorial: Innovative vaccine strategies for enhanced flavivirus immunization

in Microbial Vaccines

Srinivasa Reddy Bonam
Nitin K. Saksena
Pedro A. Reche

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1729523

1,766 views

Editorial

Published on 06 Nov 2025

Editorial: From bench to clinic: novel vaccines and therapeutics – “success stories”

in Microbial Vaccines

Arundhathi Venkatasubramaniam
Nathan K. Archer

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1701460

1,705 views

Original Research

Published on 30 Oct 2025

Comparative safety evaluation of pentavalent (DTaP-IPV-Hib) and hexavalent (DTaP-IPV-Hib-HepB) vaccines in infants: a real-world analysis based on VAERS

in Microbial Vaccines

Zhen Wei
Bai Li
Hong-Ling Jia

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1666509

4,693 views
1 citation

Original Research

Published on 16 Oct 2025

LpxR and PagL expression in live attenuated auxotrophic Pseudomonas aeruginosa vaccines modulates lipid A reactogenicity in vitro while preserving immunogenicity

in Microbial Vaccines

Miriam Moscoso
Víctor Fuentes-Valverde
Patricia García
Juan A. Vallejo
Jesús Pérez-Ortega
Rebeca Santamarina-Fernández
Ana Candela
Marina Oviaño
Jesús Arenas
Germán Bou

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1664169

2,920 views
1 citation

Review

Published on 14 Oct 2025

Advances in diagnosis and treatment of lung cancer-associated obstructive pneumonia and lung abscess: synergistic strategies for infection control and antitumor therapy

in Microbial Vaccines

Peijun Cao
Li Chen
Shaohua Xie
Bin Hu

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1638997

5,398 views
1 citation

Original Research

Published on 26 Aug 2025

Post-marketing safety surveillance of pneumococcal vaccines: a real-world pharmacovigilance study using the U.S. vaccine adverse event reporting system (VAERS) database

in Microbial Vaccines

Xinkuo Zheng
Meishen Liu
Aili Ding
Shihong Zhang
Ling Wu
Fanli Kong
Weijia Sun
Yuchen Peng
Yalin Xi

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1635180

6,671 views
1 citation

Review

Published on 28 Jul 2025

Advances in nanotechnology for the therapy of bacterial pneumonia

in Microbial Vaccines

Zihan Tian
Yuwei Zhang
Jiachen Yun
Weihong Kuang
Jin Li

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1639783

6,176 views
7 citations

58 articles

articles

Vaxjo 2.0: An ontology- and large language model-powered knowledge base of vaccine adjuvants and mechanisms

In silico design of a multiantigenic and multiepitope chimeric protein as a vaccine candidate against Renibacterium salmoninarum

Engineering low-endotoxin lipid A in a double auxotroph Pseudomonas aeruginosa to develop safer whole-cell vaccines

Editorial: Exploring the Interface of Mucosal Vaccines and Immune System Modulation

STING agonist 2'3'-cGAMP as an effective adjuvant for HPV16 peptide vaccine enhances anti-tumor immunity in TC-1 Mice models

In silico design and testing of a multi-epitope camel mastitis vaccine candidate for development

Artificial Intelligence in Vaccine Development: Applications, Implementation, and Future Directions

Repeated dose toxicity and immunogenicity studies in SD rats: a new recombinant zoster vaccine (CHO cell) formulated with adjuvant BC02

A needle-free intradermal PEDV S protein vaccine elicits protective lactogenic immunity in piglets

Two decades of global research on tetanus vaccines and tetanus immunoglobulins: a comprehensive bibliometric analysis and integrative review (2000–2025)

A computational pipeline to discover potential cross-reactive antibodies: a case study on coronavirus

Diphtheria-tetanus-acellular pertussis vaccine safety in children under 7 years: a post-marketing analysis of the U.S. vaccine adverse event reporting system

Risk signal assessment of Tdap vaccine use alone by pregnant women: An updated pharmacoepidemiological study

High-throughput identification of immunoreactive peptides and corresponding proteins from Anaplasma platys and Ehrlichia canis using peptide microarray chips

Ex vivo mucosal cultures: an emerging player in vaccine development

Evaluation of the protective efficacy of a recombinant adenovirus-vectored SARS-CoV-2 vaccine candidate for veterinary use

Differential antioxidant enzyme profiles reveal early molecular signatures of virulence in Trypanosoma cruzi DTU-TcI and DTU-TcVI strains

Editorial: Innovative vaccine strategies for enhanced flavivirus immunization

Editorial: From bench to clinic: novel vaccines and therapeutics – “success stories”

Comparative safety evaluation of pentavalent (DTaP-IPV-Hib) and hexavalent (DTaP-IPV-Hib-HepB) vaccines in infants: a real-world analysis based on VAERS

LpxR and PagL expression in live attenuated auxotrophic Pseudomonas aeruginosa vaccines modulates lipid A reactogenicity in vitro while preserving immunogenicity

Advances in diagnosis and treatment of lung cancer-associated obstructive pneumonia and lung abscess: synergistic strategies for infection control and antitumor therapy

Post-marketing safety surveillance of pneumococcal vaccines: a real-world pharmacovigilance study using the U.S. vaccine adverse event reporting system (VAERS) database

Advances in nanotechnology for the therapy of bacterial pneumonia