ORIGINAL RESEARCH article
Front. Chem.
Sec. Nanoscience
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1555449
This article is part of the Research TopicPolymer Functional CompositeView all 3 articles
Formulation Development, Characterization and Optimization of Eudragit-Cinnamon Essential Oil Based Nanoplatform and its efficacy against Resistant Bacteria
Provisionally accepted
Dr. Adnan Amin1,2*
Tauseef nawaz1
Niamat Ullah1Muhammad Ali1Safia Obaidur Rab3
Irfan Ahmad3Rabia Baloch4
Sadia Chaman5Kifayatullah Shah1- 1Gomal University, Dera Ismail Khan, Pakistan
- 2Yeungnam University, Gyeongsan, North Gyeongsang, Republic of Korea
- 3King Khalid University, Abha, Saudi Arabia
- 4Allama Iqbal Teaching Hospital, Dera Ghazi Khan, Dear Ghazi Khan, Pakistan
- 5University of Veterinary and Animal Sciences, Lahore, Punjab, Pakistan
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Microbial resistance is a growing global concern, necessitating the development of novel drug delivery system to combat the resistant bacterial strains. We aimed to formulate Eudragit based cinnamon essential oil loaded nanoplatform against resistant microbial strain.Nanoparticles were characterized for zeta potential, PDI, particle size, SEM, FTIR, entrapment efficiency and drug release kinetic. Box Behnken design with the quadratic model was used to check the effect of independent factors and dependent factors. The Klebsiella and Staphylococcus aureus have shown same MIC value of 1.25µL/ml while E. coli and Pseudomonas aeruginosa shown 0.078 and 0.625 µL/ml respectively. Quadratic polynomial equation depicted that stirring speed exhibited negative effect on the PDI, particle size and encapsulation efficiency. The polymer concentration produced positive effect on the particle size, PDI and encapsulation efficiency of the nanoparticles. The predicted response values were as particle size (Y1) 228.9 nm, PDI (Y2) 0.3 and %EE (Y3) 72.75% which were very close to the actual values of response as particle size (Y1) was 230.4 ± 3.46 nm, PDI (Y2) was 0.293 ± 0.022, and %EE (Y3) was 74.9 ± 2.32%. It was concluded that our prepared formulation can be effectively used treat resistant bacterial infections.
Keywords: Font: (Default) Calibri, 12 pt Font: (Default) Calibri bacterial resistance, Design expert, Essential oil, Eudragit, Nanoplatform
Received: 04 Jan 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 Amin, nawaz, Ullah, Ali, Rab, Ahmad, Baloch, Chaman and Shah. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dr. Adnan Amin, Gomal University, Dera Ismail Khan, Pakistan
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.