ORIGINAL RESEARCH article
Front. Chem.
Sec. Medicinal and Pharmaceutical Chemistry
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1583666
This article is part of the Research TopicRecent Advances in Synthetic Organic Chemistry at the Biomedical Interface: Honoring Professor Iwao Ojima on the Occasion of his 80th BirthdayView all 15 articles
Phomaderide, a Unique (6/5/4/5/6) Spiro-Cyclic Dimmer from the Desert Plant Endophytic Fungus Phoma betae A. B. Frank (Didymellaceae)
Provisionally accepted
- 1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
- 2Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng, Beijing Municipality, China
- 3China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China
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Phomaderide (3), a unique (6/5/4/5/6) spiro-cyclic dimer formed via stereoselective [2+2] photocycloaddition of two phaeosphaeride A (1) monomers, together with its precursor 1 and a new hydroxylated analog phaeosphaeride C (2), was isolated from the desert plant endophytic fungus Phoma betae A.B. Frank (Didymellaceae) using a building blocks-based molecular network (BBMN) strategy. Alongside its biosynthetic precursor 1, the new structures 2 and 3 were elucidated by NMR spectra, Mass fragmentation pathway, and calculated electronic circular dichroism (ECD) calculations. Bioactivity evaluation revealed moderate cytotoxicity for 2 and 3 against HeLa (IC50 29.97-39.15 μM) and A549 cells . This study highlights the metabolic versatility of extremophilic fungi and underscores phomaderide's potential as a structurally complex lead for anticancer drug discovery.
Keywords: Phomaderide, Desert Plant Endophytic Fungus, Building blocks-based molecular network, Desert Plant Endophytic Fungus,, Phoma betae A. B. Frank (Didymellaceae)
Received: 27 Feb 2025; Accepted: 20 May 2025.
Copyright: © 2025 Sun, Wang, Fang, Yang, Hua, Ding and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Haodi Sun, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
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