MINI REVIEW article
Front. Chem.
Sec. Medicinal and Pharmaceutical Chemistry
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1586044
This article is part of the Research TopicQuinoline as Lead Structures for the Development of Leishmanicidal AgentsView all 5 articles
Current Developments of Metal-and Metalloid-based Quinoline Compounds as Leishmanicidal Agents
Provisionally acceptedSelect one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Quinoline moiety represents an important scaffold for the development of leishmanicidal agents. In particular, its hybridization with metal/metalloids has generated highly active compounds and, in some cases, highly selective against leishmaniasis models. The existing leishmanicidal metal-/metalloid-quinoline compounds are mainly based on: (i) coordination compounds based on 8hydroxyquinolinate, (ii) metallocene derivatives and, (iii) N-heterocyclic carbene (NHC) complexes featuring a quinoline moiety. This mini-review summarizes the reported cases of leishmanicidal metal and metalloid-based quinoline compounds for each group (i-iii), focusing on the structureproperty relationship from in vitro Leishmania models and mechanisms of action, in vivo experiment and pharmacokinetic data, if available. This paper aims to describe the state of the art of inorganic medicinal chemistry for the development of selective and potent leishmanicidal agents using the quinoline moiety.
Keywords: Quinoline, Leishmaina, Ferrocene, NHC (N-heterocyclic carbenes), 8-Quinolinate
Received: 01 Mar 2025; Accepted: 01 May 2025.
Copyright: © 2025 . This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.