MINI REVIEW article
Front. Chem.
Sec. Medicinal and Pharmaceutical Chemistry
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1622566
This article is part of the Research TopicQuinoline as Lead Structures for the Development of Leishmanicidal AgentsView all 6 articles
Application of Nano and Microformulations to Improve the Leishmanicidal Response of Quinoline Compounds: A Brief Review
Provisionally accepted
- 1UR Universidad de la Republica, Montevideo, Uruguay
- 2UCV Central University of Caracas, Caracas, Venezuela
- 3UCV CV, Caracas, Venezuela
- 4Simón Bolívar University, Caracas, Venezuela
- 5Universidad SImon Bolivar, Caracas, Venezuela
- 6Universidad SImon Bolivar, Baruta, Venezuela
- 7USB, Caracas, Venezuela
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The quinoline represent an important scaffold for the development of leishmanicidal agents. In particular, the use of nano and microformulations has emerged as a powerful tool to improve the therapeutic profile of leishmanicidal drugs, favoring the bioavailability, the transportation to key targets, the metabolic protection and immunostimulating response. This minireview seeks to provide a general perspective about the use of nano/microencapsulation for the development of leishmanicidal formulations based on quinoline, giving an overview of the various cases of encapsulation, analyzing the repercussions of the type of polymeric matrix (synthetic or natural polymer), type of formulation (polymeric or metallic nanoparticles, micelles, liposomes, etc), drug loading percentage and release rate of quinoline drug.
Keywords: Leishmanicidal agent, DDS, quinoline drugs, Nanoparticles, Leishmania, amastigote
Received: 03 May 2025; Accepted: 27 Jun 2025.
Copyright: © 2025 Romero, Gonzalez and Sabino Gutierrez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Angel Romero, UR Universidad de la Republica, Montevideo, Uruguay
Marcos Antonio Sabino Gutierrez, Simón Bolívar University, Caracas, Venezuela
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