ORIGINAL RESEARCH article
Front. Chem.
Sec. Green and Sustainable Chemistry
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1624736
Cannabis-derived cellulose acetate electrospun membranes for therapeutic dressings: extraction, characterization, and prototype development
Provisionally accepted- 1Universidad Pedagógica y Tecnológica de Colombia-UPTC, Duitama, Colombia
- 2West Pomeranina University of Technology, Szczecin, Poland
- 3University of Barcelona, Barcelona, Spain
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This work reports the development of electrospun cellulose acetate (CA) membranes derived from Cannabis sativa biomass for potential use in therapeutic dressings. Cellulose was extracted from cannabis stalks using alkaline pulping and bleaching, followed by homogeneous acetylation to obtain CA with controlled substitution. CA solutions (13-25%) were electrospun under varying parameters, and the 17% formulation yielded the most homogeneous, bead-free nanofibers. The resulting membranes were characterized using FTIR, XRD, Raman spectroscopy, UV-Vis spectrophotometry, and SEM. FTIR and Raman confirmed acetylation through characteristic ester and methyl group vibrations. XRD revealed reduced crystallinity in CA compared to native cellulose. SEM analysis showed uniform fiber networks with diameters between 500 and 800 nm. A bilayer dressing prototype was fabricated by integrating the electrospun membrane with a medical-grade silicone adhesive. Adhesion performance was evaluated on synthetic skin using a FINAT-standardized 180° peel test. The membranes demonstrated adequate mechanical cohesion and conformability, supporting their application as sustainable, plant-based biomedical patches.
Keywords: Cellulose acetate, Electrospinning, Nanofibrous membranes, Cannabis sativa biomass, Wound Dressing, adhesive characterization
Received: 07 May 2025; Accepted: 29 May 2025.
Copyright: © 2025 Lara, Cely, Gómez, Rubiano Navarrete, López, Krzysztof Antosik, Vendrell and Serafin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Adriana Lara, Universidad Pedagógica y Tecnológica de Colombia-UPTC, Duitama, Colombia
Jaroslaw Serafin, University of Barcelona, Barcelona, Spain
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