ORIGINAL RESEARCH article
Front. Chem.
Sec. Chemical Biology
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1626741
This article is part of the Research TopicFluorescent Sensors for Biological and Environmental ApplicationsView all articles
Rational Design of A NIR Fluorescent Probe for Highly Selective Sensing of NAD(P)H quinone oxidoreductase 1 in Living Systems
Provisionally accepted
- 1General Hospital of Northern Theater Command, Department of Neurosurgery, Shenyang, China
- 2Second Affiliated Hospital of Dalian Medical University, Dalian, China
- 3College of pharmacy, Dalian Medical University, Dalian, China
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NAD(P)H quinone oxidoreductase 1 (NQO1) plays a critical role in catalyzing the reduction of quinones, thereby exerting both chemical protection and biological activation. The expression level of NQO1 in various tumor cells, especially glioma, lung cancer, colon cancer and breast cancer cells, is higher than that in normal tissues, the detection of NQO1 activity is important to understand tumor development mechanisms. Herein, a near-infrared (NIR) fluorescent probe DDANQ was reasonably designed and developed for visualizing NQO1 activity in living cells and tissues.to visually detect the activity of NQO1 in living systems, including cancer cells and tissues. The results showed that DDANQ could be used as a molecular tool to elucidate the activity and function of NQO1 in physiological and pathological processes, which could provide valuable insights for tumor diagnosis and treatment.
Keywords: NQO1, Fluorescent probe, Fluorescence Imaging, near-infrared, tumor
Received: 11 May 2025; Accepted: 04 Jun 2025.
Copyright: © 2025 Yang, Zhu, Yan, Zhang and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fei Yan, Second Affiliated Hospital of Dalian Medical University, Dalian, China
Houli Zhang, College of pharmacy, Dalian Medical University, Dalian, China
Guobiao Liang, General Hospital of Northern Theater Command, Department of Neurosurgery, Shenyang, China
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