ORIGINAL RESEARCH article
Front. Chem.
Sec. Organic Chemistry
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1631183
This article is part of the Research TopicRecent Advances in Synthetic Organic Chemistry at the Biomedical Interface: Honoring Professor Iwao Ojima on the Occasion of his 80th BirthdayView all 15 articles
Magnetic Nanocatalyst for Microwave-Assisted Synthesis of Benzo[4,5]imidazo[1,2-a]pyrimidines via A3 Coupling
Provisionally accepted
- Guangxi University, Nanning, China
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This manuscript introduces an innovative and environmentally benign magnetic nanocatalyst (NiFe2O4@MCM-41@IL/Pt(II)) designed to synthesize benzoimidazo [1,2-a]pyrimidines via a microwave-assisted, one-pot A3 coupling reaction. The methodology employs aromatic and heteroaromatic aldehydes, 2-aminobenzimidazole derivatives, and terminal alkynes in water as a green solvent, leveraging the synergistic effects of nanocatalysis and microwave irradiation. The magnetic nanocatalyst, characterized by its robust structure and high surface reactivity, facilitates rapid reaction kinetics, achieving excellent yields while significantly reducing energy consumption and reaction time compared to conventional thermal approaches. Its inherent magnetic properties enable straightforward separation and reuse across multiple cycles without appreciable loss in catalytic efficiency, aligning with sustainable chemistry principles. The protocol demonstrates broad substrate compatibility, successfully accommodating diverse aldehydes, including challenging heteroaromatic systems, to furnish a library of pharmaceutically relevant heterocycles. This broad substrate compatibility underscores the versatility of the nanocatalyst, making it a valuable tool for a wide range of chemical synthesis applications. This work highlights the transformative role of hybrid methodologies in addressing both efficiency and environmental impact in chemical synthesis.
Keywords: NiFe2O4@MCM-41@IL/Pt, A3 coupling reactions, Nanomagnetic catalyst, microwave-assisted, Imidazo[1,2-a]pyrimidines
Received: 19 May 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Pan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuqiang Pan, Guangxi University, Nanning, China
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