ORIGINAL RESEARCH article
Front. Chem.
Sec. Organic Chemistry
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1632736
This article is part of the Research TopicRecent Advances in Synthetic Organic Chemistry at the Biomedical Interface: Honoring Professor Iwao Ojima on the Occasion of his 80th BirthdayView all 18 articles
Sustainable Synthesis of Quinazolinones: Exploring Multicomponent Reactions with a Novel Magnetic Palladium Catalyst
Provisionally accepted
- Yangling Vocational & Technical College, Yangling, China
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This study introduces a sustainable and efficient method for synthesizing quinazolinones, a class of heterocyclic compounds with significant pharmaceutical applications, via a multicomponent reaction (MCR) strategy. The process employs a novel magnetically recoverable palladium catalyst, enabling the coupling of aryl or heteroaryl iodides with a carbonyl source and 2-aminobenzamide in an eco-friendly PEG/water solvent system, facilitated by potassium carbonate as a base. The magnetic Pd catalyst exhibits robust catalytic activity, achieving high product yields (82-98%) across diverse substrates, including electron-rich and electron-deficient aryl/heteroaryl iodides, underscoring its broad applicability. The catalyst is synthesized and characterized through various techniques, including FT-IR, BET, TGA, EDX, VSM, SEM, TEM, and XRD, which affirm its uniformity and stability. Key advantages of this protocol include exceptional atom economy, elimination of toxic solvents, and mild reaction conditions. The catalyst's magnetic properties allow effortless recovery via external magnetization, retaining >89% activity over five consecutive cycles, enhancing cost-effectiveness and sustainability. By integrating green solvent systems, recyclable catalysis, and operational simplicity, this approach aligns with the principles of green chemistry, offering an environmentally benign alternative to conventional methods. The methodology advances sustainable synthetic practices and holds promise for scalable applications in medicinal and industrial chemistry. This work highlights the transformative potential of magnetic nanocatalysts in developing eco-conscious routes to biologically relevant heterocycles.
Keywords: Fe 3 O 4 @SiO 2 -Dop/Phen-Pd(0) catalyst, 2-Aryl quinazolin-4(3H)-ones, Ecofriendly system, Cyclization, carbonylation
Received: 21 May 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Liang, Yang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaotong Liang, Yangling Vocational & Technical College, Yangling, China
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