ORIGINAL RESEARCH article
Front. Chem.
Sec. Analytical Chemistry
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1645843
Rapid drug detection equipment based on molecular imprinting and surface plasmon resonance technology
Provisionally accepted
- 1Department of Police Tactics, Chongqing Police College, 重庆市, China
- 2Inner mongolia police college, Inner Mongolia, China
- 3QingdaoASentTechnology Development Co., LTD., Qingdao, China
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To enhance the combat effectiveness of drug control, it is necessary to improve the sensitivity and accuracy of drug rapid detection equipment. In this paper, a new drug detection equipment with chemical sensor chip for qualitative analysis of methamphetamine hydrochloride is prepared by using molecular imprinting and surface plasmon resonance (SPR) technology. The results show that the sensitivity of the chip is still high after 8 times of adsorption and elution, and the change of reflectivity changed value is 98.5% of the initial experiment when the chip is tested after 50 days of placement. The sensor chip based on molecular imprinting and SPR technology can be used to detect methamphetamine in dusts, and the recovery rate is between 97.3% and 101.7%. The rapid drug detection equipment can detect sewage samples, organic samples and dust samples, etc. The detection limit of this equipment can reach 2.97×10-12g/ml (0.003ng/ml), and the test results can be transmitted remotely in real time.
Keywords: Molecular imprinting technique, Surface Plasmon Resonance, Methamphetamine Hydrochloride, Drug detection, sensor chips
Received: 12 Jun 2025; Accepted: 31 Jul 2025.
Copyright: © 2025 Yu, Luo, Liu, Li and Kong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Weili Luo, Inner mongolia police college, Inner Mongolia, China
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