ORIGINAL RESEARCH article
Front. Chem.
Sec. Chemical Biology
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1698116
This article is part of the Research TopicSmall-Molecule Fluorescent Probes for Investigating Medicinal ProcessesView all 3 articles
Developing a dichlorosalicylaldehyde-derived fluorescent probe for monitoring glutathione in cellular pulmonary ventilation model
Provisionally accepted
- Jinhua Municipal Central Hospital, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China., Jinhua, China
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Herein, a fluorescent probe, DSNBD-GSH, was developed from dichlorosalicylaldehyde for monitoring glutathione (GSH) in cellular pulmonary ventilation model. Both the normoxia and hypoxia conditions were evaluated. DSNBD-GSH responded towards GSH in a dosage-dependent manner with the fluorescence signal at 478 nm under the excitation of 365 nm. The tests in solution indicated that DSNBD-GSH had relatively high sensitivity for GSH, and the photophysical properties were stable in various conditions. Other advantages included rapid response, high selectivity, and low cytotoxicity. Most significantly, monitoring the GSH level in both hypoxia and recovery status, thus ventilation-related redox changes could be visualized. This work raised a referenceable case for improving the pulmonary ventilation approach in perioperative period.
Keywords: Fluorescence probe, Glutathione level, Pulmonary Ventilation, Cellular model, dichlorosalicylaldehyde derivative
Received: 03 Sep 2025; Accepted: 15 Sep 2025.
Copyright: © 2025 Zhou, Zhang, Lao, Zhou and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhong-Quan Zhu, zhuzqzxyy@163.com
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