MINI REVIEW article
Front. Chem.
Sec. Chemical Physics and Physical Chemistry
This article is part of the Research TopicAdvancing Biomedical Innovation Through Piezoelectric MaterialsView all articles
Advances and crosslinking of the piezoelectric nanoplatform: Exploring the multifunctionality in different biomedical applications
Provisionally accepted
- 1Jadavpur University, Kolkata, India
- 2Harbin Institute of Technology Shenzhen, Shenzhen, China
- 3Jogamaya Devi College, Kolkata, India
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Piezoelectric materials have emerged as versatile platforms with transformative potential in biomedical research, yet their clinical translation remains limited. This mini review examines how these materials generate reactive oxygen species (ROS) under mechanical stimulation to regulate biological processes, enabling antibacterial activity, wound repairing, tissue regeneration, and targeted cancer therapy through piezodynamic, chemodynamic, and photothermal pathways. Beyond treatment, piezoelectric materials facilitate controlled drug and gene delivery and function as self-powered biosensors for real-time monitoring. To this end, we also discuss key challenges hindering clinical translation, including instability, precipitation, fabrication complexity, and long-term biocompatibility, and conclude by outlining future strategies for developing flexible, biodegradable, AI-integrated platforms for precision and adaptive healthcare.
Keywords: piezoelectric materials, reactive oxygen species (ROS), biomedical applications, piezodynamic therapy, Tissue Regeneration, Self-powered Biosensors
Received: 27 Sep 2025; Accepted: 31 Oct 2025.
Copyright: © 2025 Roy, Madni, Sau, Basu and Das. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ruma Basu, ruma.b1959@gmail.com
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