Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Published on 03 Jul 2024

Discovery and prospects of new heterocyclic Isatin-hydrazide derivative with a novel role as estrogen receptor α degrader in breast cancer cells

in Medicinal and Pharmaceutical Chemistry

Muhammad Nouman Arif
Sadia Sarwar
Farhat Firdous
Rahman Shah Zaib Saleem
Humaira Nadeem
Abir Abdullah Alamro
Amani Ahmad Alghamdi
Atekah Hazza Alshammari
Omer Farooq
Rashid Ali Khan

Frontiers in Chemistry

doi 10.3389/fchem.2024.1424637

7,169 views
3 citations

Review

Published on 02 Jul 2024

Research progress of Gastrodia elata Blume polysaccharides: a review of chemical structures and biological activities

in Medicinal and Pharmaceutical Chemistry

Liu Yang
Shi-Hui Qin
Cheng-Ting Zi

Frontiers in Chemistry

doi 10.3389/fchem.2024.1395222

4,559 views
13 citations

Original Research

Published on 26 Jun 2024

Design, synthesis, and evaluation of 1,4-benzothiazine-3-one containing bisamide derivatives as dual inhibitors of Staphylococcus aureus with plausible application in a urinary catheter

in Medicinal and Pharmaceutical Chemistry

Kaushal Naithani
Arka Das
Mamta Ushare
Subham Nath
Rashmita Biswas
Anirban Kundu
Kazi Tawsif Ahmed
Utpal Mohan
Subhendu Bhowmik

Frontiers in Chemistry

doi 10.3389/fchem.2024.1420593

4,656 views
1 citation

Editorial

Published on 25 Jun 2024

Editorial: Five-membered heterocycles: synthesis and applications

in Medicinal and Pharmaceutical Chemistry

Mohammad Abrar Alam

Frontiers in Chemistry

doi 10.3389/fchem.2024.1445671

4,058 views
2 citations

Editorial

Published on 24 Jun 2024

Editorial: Computational drug discovery of medicinal compounds for cancer management, volume II

in Medicinal and Pharmaceutical Chemistry

Khurshid Ahmad
Sibhghatulla Shaikh
Faez Iqbal Khan
Mohammad Ehtisham Khan

Frontiers in Chemistry

doi 10.3389/fchem.2024.1446510

1,464 views
1 citation

Correction

Published on 18 Jun 2024

Corrigendum: HSA-nanobinders crafted from bioresponsive prodrugs for combined cancer chemoimmunotherapy–an in vitro exploration

in Medicinal and Pharmaceutical Chemistry

Matilde Tubertini
Luca Menilli
Celeste Milani
Cecilia Martini
Maria Luisa Navacchia
Marta Nugnes
Manuela Bartolini
Marina Naldi
Daniele Tedesco
Elisa Martella

Frontiers in Chemistry

doi 10.3389/fchem.2024.1443822

1,006 views

Original Research

Published on 18 Jun 2024

In silico discovery of potential PPI inhibitors for anti-lung cancer activity by targeting the CCND1-CDK4 complex via the P21 inhibition mechanism

in Medicinal and Pharmaceutical Chemistry

Weijian Tang
Tao Shen
Zhoumiao Chen

Frontiers in Chemistry

doi 10.3389/fchem.2024.1404573

2,497 views
5 citations

Original Research

Published on 11 Jun 2024

In vivo and in silico studies of the effects of oil extracted from Cannabis sativa L. seeds on healing of burned skin wounds in rats

in Medicinal and Pharmaceutical Chemistry

Mouna Bouarfa
Mohamed Chebaibi
Fatima Ez-Zahra Amrati
Zouhair Souirti
Hamza Saghrouchni
Yassine El atki
Khalid Bekkouche
Hajar Mourabiti
Amina Bari
John P. Giesy

Frontiers in Chemistry

doi 10.3389/fchem.2024.1381527

3,073 views
3 citations

Original Research

Published on 10 Jun 2024

Natural product nanozymes of herbal extract galangin in managing hepatocellular carcinoma

in Medicinal and Pharmaceutical Chemistry

Erhao Wang
Yuxia Wu
Yan Wang
Jiao Li
Xiuzhen Liang
Zhongtao Wang
Xiaofei Liu
Faming Feng
JianCang Mao
Yingqi Zhu

Frontiers in Chemistry

doi 10.3389/fchem.2024.1426634

1,999 views
3 citations

Original Research

Published on 07 Jun 2024

Discovery of new Schiff bases of the disalicylic acid scaffold as DNA gyrase and topoisomerase IV inhibitors endowed with antibacterial properties

in Medicinal and Pharmaceutical Chemistry

Lamya H. Al-Wahaibi
Mohamed A. Mahmoud
Hayat Ali Alzahrani
Hesham A. Abou-Zied
Hesham A. M. Gomaa
Bahaa G. M. Youssif
Stefan Bräse
Safwat M. Rabea

Frontiers in Chemistry

doi 10.3389/fchem.2024.1419242

3,482 views
11 citations

Original Research

Published on 07 Jun 2024

Study on the design, synthesis, and activity of anti-tumor staple peptides targeting MDM2/MDMX

in Medicinal and Pharmaceutical Chemistry

Jian Yang
Xiufei Liao
Damin Hu
Jinqiu Mo
Xiurong Gao
Hongli Liao

Frontiers in Chemistry

doi 10.3389/fchem.2024.1403473

1,722 views
2 citations

Original Research

Published on 03 Jun 2024

Inhibition mechanism investigation of quercetagetin as a potential tyrosinase inhibitor

in Medicinal and Pharmaceutical Chemistry

Faliang Liang

Frontiers in Chemistry

doi 10.3389/fchem.2024.1411801

2,493 views
4 citations

Original Research

Published on 03 Jun 2024

A novel approach to assessing the antioxidant and anti-diabetic potential of synthesized calcium carbonate nanoparticles using various extracts of Ailanthus altissima

in Medicinal and Pharmaceutical Chemistry

Noreen Samad
Umer Ejaz
Saba Kousar
Aamal A. Al-Mutairi
Arslan Khalid
Zeemal Seemab Amin
Shahzad Bashir
Sami A. Al-Hussain
Ali Irfan
Magdi E. A. Zaki

Frontiers in Chemistry

doi 10.3389/fchem.2024.1345950

2,913 views
5 citations

Original Research

Published on 31 May 2024

Prenylflavonoids isolated from Epimedii Herba show inhibition activity against advanced glycation end-products

in Medicinal and Pharmaceutical Chemistry

Keisuke Nakashima
Hiroyuki Miyashita
Hitoshi Yoshimitsu
Yukio Fujiwara
Ryoji Nagai
Tsuyoshi Ikeda

Frontiers in Chemistry

doi 10.3389/fchem.2024.1407934

2,206 views
3 citations

Editorial

Published on 31 May 2024

Editorial: Metallodrugs in cancer therapy: past, present and new strategies

in Medicinal and Pharmaceutical Chemistry

Irena Kostova

Frontiers in Chemistry

doi 10.3389/fchem.2024.1428502

1,576 views
2 citations

Mini Review

Published on 31 May 2024

The recent advances in the approach of artificial intelligence (AI) towards drug discovery

in Medicinal and Pharmaceutical Chemistry

Mahroza Kanwal Khan
Mohsin Raza
Muhammad Shahbaz
Iftikhar Hussain
Muhammad Farooq Khan
Zhongjian Xie
Syed Shoaib Ahmad Shah
Ayesha Khan Tareen
Zoobia Bashir
Karim Khan

Frontiers in Chemistry

doi 10.3389/fchem.2024.1408740

10,943 views
16 citations