Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Published on 04 Feb 2025

Molecular characterization, chemical profile and biological properties of essential oils from Chamaemelum nobile (L.) flowers of Morocco: in vitro and in silico studies

in Medicinal and Pharmaceutical Chemistry

El-Mehdi El-Assri
Youssef El-Assri
Rajae El Brahimi
Mohamed El fadili
Asmae Baghouz
Hatem A. Abuelizz
Sara Er-Rahmani
Amal Lahkimi
Abdelhak Bouia

Frontiers in Chemistry

doi 10.3389/fchem.2025.1539872

1,633 views

Editorial

Published on 03 Feb 2025

Editorial: Exploring novel approaches to small molecule kinase inhibitors in cancer treatment

in Medicinal and Pharmaceutical Chemistry

Anna Carbone
Rafael M. Couñago
Cristian O. Salas
Alessandra Moltalbano

Frontiers in Chemistry

doi 10.3389/fchem.2025.1559849

996 views

Review

Published on 29 Jan 2025

4-Aminoquinoline as a privileged scaffold for the design of leishmanicidal agents: structure–property relationships and key biological targets

in Medicinal and Pharmaceutical Chemistry

Angel H. Romero
Francisco Delgado

Frontiers in Chemistry

doi 10.3389/fchem.2024.1527946

2,405 views
3 citations

Original Research

Published on 29 Jan 2025

Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents

in Medicinal and Pharmaceutical Chemistry

Hongtao Du
Fang Ma
Yuanyuan Cao
Miaoyan Bai
Xinyi Gao
Ziyi Yang
Yang Xu
Yan Yan

Frontiers in Chemistry

doi 10.3389/fchem.2025.1545908

1,135 views

Original Research

Published on 24 Jan 2025

Anti-cancer activity of synthetic gefitinib-1,2,3-triazole derivatives against Hela cells via induction of apoptosis

in Medicinal and Pharmaceutical Chemistry

Zhihong Hu
Xixi Hou
Yongjing Ren
Ziyuan Wu
Dong Yan
Hong Chen
Lan Wang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1456743

1,423 views

Original Research

Published on 23 Jan 2025

Microbial-based natural products as potential inhibitors targeting DNA gyrase B of Mycobacterium tuberculosis: an in silico study

in Medicinal and Pharmaceutical Chemistry

Tilal Elsaman
Magdi Awadalla Mohamed
Malik Suliman Mohamed
Eyman Mohamed Eltayib
Abualgasim Elgaili Abdalla

Frontiers in Chemistry

doi 10.3389/fchem.2025.1524607

1,975 views
3 citations

Original Research

Published on 20 Jan 2025

Discovery of novel PRMT1 inhibitors: a combined approach using AI classification model and traditional virtual screening

in Medicinal and Pharmaceutical Chemistry

Jungan Zhang
Yixin Ren
Yun Teng
Han Wu
Jingsu Xue
Lulu Chen
Xiaoyue Song
Yan Li
Ying Zhou
Zongran Pang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1548812

1,373 views

Original Research

Published on 17 Jan 2025

In silico identification of the anticataract target of βB2-crystallin from Phaseolus vulgaris: a new insight into cataract treatment

in Medicinal and Pharmaceutical Chemistry

Sunday Amos Onikanni
Adewale Oluwaseun Fadaka
Tran Nhat Phong Dao
Valens Munyembaraga
Vincent Nyau
Nicole Remaliah Samantha Sibuyi
Morenike Grace Ajayi
Nguyen Thi Ai Nhung
Emmanuel Ejiofor
Basiru Olaitan Ajiboye

Frontiers in Chemistry

doi 10.3389/fchem.2024.1421534

1,601 views

Original Research

Published on 16 Jan 2025

Exploring the potential of some natural indoles as antiviral agents: quantum chemical analysis, inverse molecular docking, and affinity calculations

in Medicinal and Pharmaceutical Chemistry

Amany Belal
Aly Abdou
Samar F. Miski
Mohamed A. M. Ali
Heba I. Ghamry
Ahmad J. Obaidullah
Mohamed Y. Zaky
Ahmed H. E. Hassan
Eun Joo Roh
Ahmed A. Al-Karmalawy

Frontiers in Chemistry

doi 10.3389/fchem.2024.1521298

2,141 views

Original Research

Published on 15 Jan 2025

Syzygium aromaticum extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities

in Medicinal and Pharmaceutical Chemistry

Zehra Edis
Samir Haj Bloukh
Akram A. Ashames
Moawia M. Al-Tabakha
Moyad J. S. A. Shahwan
Hamed Abu Sara
Sai H. S. Boddu
Sohaib N. Khan
Ibrahim Haj Bloukh
Maram Eladdasy

Frontiers in Chemistry

doi 10.3389/fchem.2024.1513150

1,738 views
3 citations

Original Research

Published on 14 Jan 2025

A computational chemistry-based approach to optimizing PD-1/PD-L1 inhibitors

in Medicinal and Pharmaceutical Chemistry

Meijuan Zhai
Shiliang Ji
Haoran Hu
Yongjie Wu
Yi Shi
Ruifang Zhu
Yiguo Jiang
Yang Yang

Frontiers in Chemistry

doi 10.3389/fchem.2024.1533541

1,088 views

Original Research

Published on 13 Jan 2025

Design, synthesis, and apoptotic antiproliferative action of new benzimidazole/1,2,3-triazole hybrids as EGFR inhibitors

in Medicinal and Pharmaceutical Chemistry

Alshimaa A. Y. Ahmed
Anber F. Mohammed
Zainab M. Almarhoon
Stefan Bräse
Bahaa G. M. Youssif

Frontiers in Chemistry

doi 10.3389/fchem.2024.1541846

4,511 views

Original Research

Published on 09 Jan 2025

Two previously undescribed triterpenoid saponins from the roots and rhizomes of Caulophyllum robustum Maxim

in Medicinal and Pharmaceutical Chemistry

Cong-Yu Zhang
Yu-Mei Wang
Peng-Cheng Qiu
Jia-Yu Feng
Bing-Wen Wang
Yu Cao
Yi-Sha Wei
Yi-Tong Zhou
Hai-Feng Tang
Yun-Yang Lu

Frontiers in Chemistry

doi 10.3389/fchem.2024.1507891

1,127 views

Original Research

Published on 09 Jan 2025

Machine learning and molecular dynamics simulations predict potential TGR5 agonists for type 2 diabetes treatment

in Medicinal and Pharmaceutical Chemistry

Ojochenemi A. Enejoh
Chinelo H. Okonkwo
Hector Nortey
Olalekan A. Kemiki
Ainembabazi Moses
Florence N. Mbaoji
Abdulrazak S. Yusuf
Olaitan I. Awe

Frontiers in Chemistry

doi 10.3389/fchem.2024.1503593

2,832 views
4 citations

Original Research

Published on 06 Jan 2025

Exploring the antifungal potential of Cannabis sativa-derived stilbenoids and cannabinoids against novel targets through in silico protein interaction profiling

in Medicinal and Pharmaceutical Chemistry

Kevser Kübra Kırboğa
Aman Karim
Ecir Uğur Küçüksille
Mithun Rudrapal
Johra Khan
Raghu Ram Achar
Ekaterina Silina
Natalia Manturova
Victor Stupin

Frontiers in Chemistry

doi 10.3389/fchem.2024.1515424

1,407 views
1 citation

Original Research

Published on 03 Jan 2025

Establishment of fingerprint of phenolic compounds in Semen Ziziphi Spinosae and study on the spectrum-effect relationship based on different preceding cropping areas

in Medicinal and Pharmaceutical Chemistry

Junfeng Jiang
Jun Luo
Wenyu Zheng
Jiayi Liu
Hui Jiang
Cuiyun Wu
Hongjin Bai

Frontiers in Chemistry

doi 10.3389/fchem.2024.1520586

1,139 views