Frontiers in Drug Discovery

Volume 5 - 2025

Original Research

Accepted on 20 Oct 2025

Leveraging Human Cardiac New Approach Methodologies (NAMs) to Evaluate the Combination of Repolarization Prolonging and Shortening Drugs

Robert Michael Geiger
Carlos Serna III
Bhavya Bhardwaj
Tromondae K Feaster
Ksenia Blinova

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1679626

Original Research

Published on 17 Sep 2025

Influence of divalent metal ions on gelation of a short heterochiral peptide

Giulio Pota
Daniele Florio
Luca Cimmino
Paolo Antonio Netti
Valeria Panzetta
Daniela Marasco
Sara La Manna

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1673051

659 views

Original Research

Published on 10 Sep 2025

Bioinformatics-driven identification and prioritization of PTSD targets based on published multi-omic data

Mark Zervas
Allyson Gage
Magali Haas

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1613261

1,190 views

Perspective

Published on 03 Sep 2025

Advancing histone deacetylase 6 (HDAC6) as a promising therapeutic target for Alzheimer’s disease: from molecular insights to clinical prospects

Wei Zhang
Yueyang Zhang
Yanli Wang
Changning Wang
Can Zhang

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1662691

1,219 views

Opinion

Published on 25 Aug 2025

On the biologically relevant chemical space: BioReCS

José L. Medina-Franco
Edgar López-López
Juan F. Avellaneda-Tamayo
William J. Zamora

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1674289

2,133 views

Mini Review

Published on 26 Jun 2025

AI-driven innovation in antibody-drug conjugate design

Heather A. Noriega
Xiang Simon Wang

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1628789

5,813 views
3 citations

Editorial

Published on 10 Jun 2025

Editorial: Pharmacokinetics modeling in the Artificial Intelligence Era

Simone Brogi
Patric Schyman
Vishal B. Siramshetty

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1636070

1,552 views

Original Research

Published on 06 Jun 2025

Dual upregulation of miRNA-143 and miRNA-506 in non-small cell lung cancer inhibits proliferation, motility, migration, and tumor growth

Archana Shrestha
Md Anamul Haque
Prajesh Shrestha
Margarita Lamprou
Seetharama D. Jois
Constantinos M. Mikelis
George Mattheolabakis

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1584801

1,802 views

Editorial

Published on 04 Jun 2025

Editorial: Enhancing drug discovery through structure-based design and computational techniques

Rajesh Kumar Pathak
Dev Bukhsh Singh
Binh P. Nguyen

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1632015

1,519 views

Original Research

Published on 30 May 2025

Safety and tolerability of a bevacizumab biosimilar (Effivia®) in adult Mexican patients with cancer: a multicenter, observational, prospective clinical study

Alberto Alfonso Pimentel-Rentería
David Francisco Cantú de León
Eliseo Neftalí De la Cruz
David Suárez
Manuel Rodulfo Segura
José Gustavo Núñez
Livan Delgado-Roche

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1591991

1,344 views

Original Research

Published on 15 Apr 2025

Identification of natural compounds as potential inhibitors of Interleukin-23: virtual screening, ADMET, drug-likeness, and dynamic simulation

Davood Gheidari
Morteza Mehrdad
Mahan Etedali

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1525533

2,254 views
5 citations

Original Research

Published on 21 Feb 2025

Transduction of hematopoietic stem and progenitor cells by an MECP2 lentiviral vector improves Rett syndrome phenotypes

Joseph S. Anderson
Jill L. Silverman
Alyse L. Lodigiani
Camilla M. Barbaduomo
Julie R. Beegle

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1545391

1,873 views

Editorial

Published on 20 Feb 2025

Editorial: Exploring drug development with single cell omics analytics and stem cell-based disease models

Linheng Li
Fuchou Tang
Hongkui Deng

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1561985

1,220 views

Perspective

Published on 19 Feb 2025

Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury

K. Taylor
R. Ram
L. Ewart
C. Goldring
G. Russomanno
G. P. Aithal
T. Kostrzewski
C. Bauch
J. M. Wilkinson
S. Modi

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1536756

4,508 views
1 citation

Review

Published on 29 Jan 2025

Non-enzymatic protein targeting agents as a promising strategy for cancer treatment

Madison Ambrose
Jeremy Lee
Aleem Syed
Zamal Ahmed
Guang Peng

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1520734

5,053 views

Volume 4 - 2024

Original Research

Published on 03 Jan 2025

Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity

Stefanie Hoffmann
Philip Hewitt
Isabel Koscielski
Dorota Kurek
Wouter Strijker
Kinga Kosim

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1459424

3,450 views
3 citations