Frontiers in Genetics

Original Research

Published on 14 Aug 2025

The rare hemoglobin variants Hb O-Arab and Hb D-Punjab identified in population-based genetic screening throughout Guangxi, China

in Genetics of Common and Rare Diseases

Chunrong Gui
Zifeng Cheng
Yongsheng Chen
Yunting Ma
Hongfei Chen
Wei Wei
Xianda Wei
Juliang Liu
Xu Zhou
Qianqian Du

Frontiers in Genetics

doi 10.3389/fgene.2025.1622391

2,955 views

Original Research

Published on 14 Aug 2025

Construction and immunohistochemical validation of a necroptosis-related prognostic signature in bladder cancer and its association with tumor immune infiltration

in Cancer Genetics and Oncogenomics

Tao Wang
Fei Ding
Kai Sun

Frontiers in Genetics

doi 10.3389/fgene.2025.1527907

2,930 views

Original Research

Published on 14 Aug 2025

Cis-regulation analysis of RNA m6A methylation and gene expression in colorectal cancer

in Genomic Assay Technology

Zhen-Liang Lin
Pan-Pan Yu
Bei-Lei Ye

Frontiers in Genetics

doi 10.3389/fgene.2025.1622957

3,336 views
1 citation

Original Research

Published on 13 Aug 2025

High-throughput sequencing unravels placental vascular dysfunction and oxidative stress as mechanistic drivers of advanced maternal age-associated pregnancy

in Human and Medical Genomics

Xin Sun
Yao Chen
Feifei Hu
Yumeng Qiao
He Wu
Yao Su
Yue Hu
Jie Wu
Mingli Huang

Frontiers in Genetics

doi 10.3389/fgene.2025.1636834

2,577 views

Review

Published on 13 Aug 2025

Machine learning tools for deciphering the regulatory logic of enhancers in health and disease

in Human and Medical Genomics

Spyros Foutadakis
Vasiliki Bourika
Ioanna Styliara
Panagiotis Koufargyris
Asimina Safarika
Eleni Karakike

Frontiers in Genetics

doi 10.3389/fgene.2025.1603687

3,431 views
1 citation

Original Research

Published on 13 Aug 2025

Integrative multi-omics analysis and machine learning reveal the unique role of ASCC3 in combination with various immune-related genes in rectal adenocarcinoma

in Cancer Genetics and Oncogenomics

Chuang Miao
Fei Qian

Frontiers in Genetics

doi 10.3389/fgene.2025.1614946

2,918 views

Case Report

Published on 13 Aug 2025

Case Report: Unmasking the role of rem sleep in modulating non-convulsive status epilepticus in ring chromosome 20 syndrome: a genetic disorder of sleep architecture?

in Genetics of Common and Rare Diseases

Filippo Mandato
Maria Teresa Di Claudio
Umberto Costantino
Francesca Rovito
Orazio Palumbo
Pietro Palumbo
Angela La Neve
Maura Pugliatti
M. Castori
Massimo Carella

Frontiers in Genetics

doi 10.3389/fgene.2025.1626457

2,188 views

Original Research

Published on 13 Aug 2025

A comprehensive analysis identifies and validates NPC1 as a potential biomarker for prognosis in HCC

in Cancer Genetics and Oncogenomics

Xingjun Lu
Tianyao Gou
Xuxing He
Xia Chen
Daqing Yang
Xiaozhen Peng

Frontiers in Genetics

doi 10.3389/fgene.2025.1588583

2,282 views

Original Research

Published on 13 Aug 2025

Genetic analysis of non-syndromic peg lateralis using whole-exome sequencing

in Genetics of Common and Rare Diseases

Junglim Choi
Sungnam Kim
Hyunsoo Ahn
Donghyo Kim
Sung-Won Cho
Sanguk Kim
Jae Hoon Lee

Frontiers in Genetics

doi 10.3389/fgene.2025.1572966

2,054 views
1 citation

Original Research

Published on 13 Aug 2025

The association between diabetes and head and neck squamous cell carcinoma: evidence from clinical cohort and bioinformatics analyses

in Cancer Genetics and Oncogenomics

Yurong He
Jiaming Chen
Boxuan Han
Yanming Zhao
Lizhen Hou
Jugao Fang
Meng Lian

Frontiers in Genetics

doi 10.3389/fgene.2025.1660012

2,241 views
2 citations

Editorial

Published on 12 Aug 2025

Editorial: Next generation sequencing and cancer: new steps towards personalized medicine

in Cancer Genetics and Oncogenomics

Erika Bandini
Clévia Rosset

Frontiers in Genetics

doi 10.3389/fgene.2025.1675753

2,234 views

Editorial

Published on 12 Aug 2025

Editorial: Genetics of non-syndromic hearing loss

in Genetics of Common and Rare Diseases

Caio Robledo D’ Angioli Costa Quaio
Saba Battelino

Frontiers in Genetics

doi 10.3389/fgene.2025.1665942

1,801 views

Case Report

Published on 11 Aug 2025

Identification of a novel, pathogenic CREBBP variant in a patient with Menke-Hennekam syndrome: a Case Report

in Genetics of Common and Rare Diseases

Anna Μaria Anastasiou
Constantia Aristidou
Athina Theodosiou
Ludmila Kousoulidou
Ioannis Papaevripidou
Angelos Alexandrou
Paola Evangelidou
Carolina Sismani
George A. Tanteles
Despina Sanoudou

Frontiers in Genetics

doi 10.3389/fgene.2025.1585453

3,571 views

Review

Published on 11 Aug 2025

Enhancing quality and climate resilient traits in vegetatively propagated polyploids: transgenic and genome editing advancements, challenges and future directions

in Genetics and Genomics of Plants and Plant-Associated Organisms

Surya Krishna Sakthivel
Amaranatha Reddy Vennapusa
Kalpalatha Melmaiee

Frontiers in Genetics

doi 10.3389/fgene.2025.1599242

3,681 views
4 citations

Original Research

Published on 11 Aug 2025

Identification of epithelial-mesenchymal transition prognostic signature associated with prognosis, tumor microenvironment, and therapeutic effect in prostate cancer

in Cancer Genetics and Oncogenomics

Yiyuan Li
Ke Li
Hua Wang
Jianguang Qiu
Chutian Xiao

Frontiers in Genetics

doi 10.3389/fgene.2025.1539745

2,634 views
1 citation

Original Research

Published on 11 Aug 2025

Identification and experimental validation of prognostic genes related to cytochrome c in breast cancer

in Cancer Genetics and Oncogenomics

Huimin Yu
Shihong Li
Jian Wu
Haobin Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1627134

2,624 views

Brief Research Report

Published on 08 Aug 2025

A unique case of late-onset CIPO caused by a missense mutation in the long isoform of FLNA

in Genetics of Common and Rare Diseases

Ilaria D’Amato
Enrico Ganguzza
Guido Basilisco
Alessia Strippoli
Erika Salvi
Elkadia Mehmeti
Federica Chiappori
Grazia Devigili
Maurizio Vecchi
Giuseppe Lauria

Frontiers in Genetics

doi 10.3389/fgene.2025.1611614

2,275 views

Original Research

Published on 08 Aug 2025

Clinical and molecular findings in actin-related inborn errors of immunity: the middle East and North Africa registry

in Genetics of Common and Rare Diseases

Zahra Chavoshzadeh
Shahrzad Fallah
Vahide Zeinali
Samin Sharafian
Samaneh Delavari
Mehrnaz Mesdaghi
Reda Djidjik
Brahim Belaid
Aydan Ikinciogullari
Sule Haskologlu

Frontiers in Genetics

doi 10.3389/fgene.2025.1584681

5,094 views

Methods

Published on 08 Aug 2025

BANSMDA: a computational model for predicting potential microbe-disease associations based on bilinear attention networks and sparse autoencoders

in Computational Genomics

Xianzhi Liu
Mingmin Liang
Ge Yu
Shichang Tang
Ouxiang Wu
Bin Zeng
Lei Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1618472

1,504 views
1 citation

Original Research

Published on 08 Aug 2025

Identification and splicing analysis of the first deep intronic FIG4 variant causing Yunis–Varon syndrome

in Genetics of Common and Rare Diseases

Hui Tang
Qingqing Chen
Jingjing Xiang
Qin Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1624122

1,523 views

Perspective

Published on 08 Aug 2025

Is the concept of mammalian epigenetic clocks universal and applicable to invertebrates?

in Epigenomics and Epigenetics

Ryszard Maleszka

Frontiers in Genetics

doi 10.3389/fgene.2025.1633921

4,014 views
1 citation

Original Research

Published on 08 Aug 2025

Winner’s curse in rare variant analysis: effect size estimation bias depends on effect direction and the association method used

in Statistical Genetics and Methodology

David Soave
Melisa Hayalioglu
Lei Sun

Frontiers in Genetics

doi 10.3389/fgene.2025.1416673

2,619 views

Original Research

Published on 07 Aug 2025

From ownership to custodianship: rethinking human biospecimens data governance in the Chinese context

in ELSI in Science and Genetics

Yifan Peng
Jiyuan Li
Ruipeng Lei

Frontiers in Genetics

doi 10.3389/fgene.2025.1621739

2,322 views

Correction

Published on 07 Aug 2025

Correction: Association between genetically proxied glucosamine and risk of cancer and non-neoplastic disease: a mendelian randomization study

in Statistical Genetics and Methodology

Yingtong Wu
Yinggang Che
Yong Zhang
Yanlu Xiong
Chen Shu
Jun Jiang
Gaozhi Li
Lin Guo
Tianyun Qiao
Shuwen Li

Frontiers in Genetics

doi 10.3389/fgene.2025.1660021

1,647 views

16,574 articles

articles

The rare hemoglobin variants Hb O-Arab and Hb D-Punjab identified in population-based genetic screening throughout Guangxi, China

Construction and immunohistochemical validation of a necroptosis-related prognostic signature in bladder cancer and its association with tumor immune infiltration

Cis-regulation analysis of RNA m6A methylation and gene expression in colorectal cancer

High-throughput sequencing unravels placental vascular dysfunction and oxidative stress as mechanistic drivers of advanced maternal age-associated pregnancy

Machine learning tools for deciphering the regulatory logic of enhancers in health and disease

Integrative multi-omics analysis and machine learning reveal the unique role of ASCC3 in combination with various immune-related genes in rectal adenocarcinoma

Case Report: Unmasking the role of rem sleep in modulating non-convulsive status epilepticus in ring chromosome 20 syndrome: a genetic disorder of sleep architecture?

A comprehensive analysis identifies and validates NPC1 as a potential biomarker for prognosis in HCC

Genetic analysis of non-syndromic peg lateralis using whole-exome sequencing

The association between diabetes and head and neck squamous cell carcinoma: evidence from clinical cohort and bioinformatics analyses

Editorial: Next generation sequencing and cancer: new steps towards personalized medicine

Editorial: Genetics of non-syndromic hearing loss

Identification of a novel, pathogenic CREBBP variant in a patient with Menke-Hennekam syndrome: a Case Report

Enhancing quality and climate resilient traits in vegetatively propagated polyploids: transgenic and genome editing advancements, challenges and future directions

Identification of epithelial-mesenchymal transition prognostic signature associated with prognosis, tumor microenvironment, and therapeutic effect in prostate cancer

Identification and experimental validation of prognostic genes related to cytochrome c in breast cancer

A unique case of late-onset CIPO caused by a missense mutation in the long isoform of FLNA

Clinical and molecular findings in actin-related inborn errors of immunity: the middle East and North Africa registry

BANSMDA: a computational model for predicting potential microbe-disease associations based on bilinear attention networks and sparse autoencoders

Identification and splicing analysis of the first deep intronic FIG4 variant causing Yunis–Varon syndrome

Is the concept of mammalian epigenetic clocks universal and applicable to invertebrates?

Winner’s curse in rare variant analysis: effect size estimation bias depends on effect direction and the association method used

From ownership to custodianship: rethinking human biospecimens data governance in the Chinese context

Correction: Association between genetically proxied glucosamine and risk of cancer and non-neoplastic disease: a mendelian randomization study