Frontiers in Genetics

Original Research

Published on 01 May 2025

Development and validation of a polygenic risk score for height in a Greek cohort: Association with blood pressure measurements

in Applied Genetic Epidemiology

Ioanna Panagiota Kalafati
Margaritis Tsifintaris
Maria Dimitriou
Effimia Grigoriou
Panagiotis Moulos
George V. Dedoussis

Frontiers in Genetics

doi 10.3389/fgene.2025.1538975

3,022 views

Review

Published on 01 May 2025

In vitro 3D modeling of colorectal cancer: the pivotal role of the extracellular matrix, stroma and immune modulation

in Cancer Genetics and Oncogenomics

Veroniaina Hanitrarimalala
Zdenka Prgomet
My Hedhammar
Helena Tassidis
Anette Gjörloff Wingren

Frontiers in Genetics

doi 10.3389/fgene.2025.1545017

4,806 views
3 citations

Original Research

Published on 01 May 2025

Radiomic features and tumor immune microenvironment associated with anaplastic lymphoma kinase-rearranged lung adenocarcinoma and their prognostic value

in Cancer Genetics and Oncogenomics

Ying Han
Wenya Feng
Huaxin Li
Hua Wang
Zhaoxiang Ye

Frontiers in Genetics

doi 10.3389/fgene.2025.1581937

2,338 views
1 citation

Original Research

Published on 01 May 2025

Identification of potential crucial genes and mechanisms associated with metabolically unhealthy obesity based on the gene expression profile

in Genetics of Common and Rare Diseases

Qingqing Wang
Silu Wang
Zhanyu Zhuang
Xueting Wu
Hongkun Gao
Tianyi Zhang
Guorong Zou
Xing Ge
Yapeng Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1540721

2,013 views
1 citation

Review

Published on 30 Apr 2025

Leveraging long-read sequencing technologies for pharmacogenomic testing: applications, analytical strategies, challenges, and future perspectives

in Pharmacogenetics and Pharmacogenomics

Alireza Tafazoli
Mahboobeh Hemmati
Mahboobeh Rafigh
Maliheh Alimardani
Faeze Khaghani
Michał Korostyński
Jason H. Karnes

Frontiers in Genetics

doi 10.3389/fgene.2025.1435416

5,339 views
10 citations

Original Research

Published on 30 Apr 2025

Impact of nonsynonymous single nucleotide polymorphisms in PROCR gene on protein stability and thrombotic risk: a molecular dynamic approach

in Computational Genomics

Hytham Ahmed Abuagla
Khalid Mohamed Adam
Mohamed E. Elangeeb
Elsadig Mohamed Ahmed
Elshazali W. Ali
Ali M. Edris
Abubakr Ali Elamin MohamedAhmed
Elmoiz Idris Eltieb
Tarig Babikir Algak Khalid
Bahaeldin K. Elamin

Frontiers in Genetics

doi 10.3389/fgene.2025.1580993

2,198 views

Original Research

Published on 30 Apr 2025

Genetic architecture of thermotolerance traits in beef cattle: a novel integration of SNP and breed-of-origin effects

in Livestock Genomics

Gabriel A. Zayas
Camila Santos Rojas
Eduardo E. Rodriguez
Aakilah S. Hernandez
Ashley M. Beard
Fahad Rafiq
Kaitlyn M. Sarlo Davila
Raluca G. Mateescu

Frontiers in Genetics

doi 10.3389/fgene.2025.1576966

3,732 views

Original Research

Published on 30 Apr 2025

High-precision lung cancer subtype diagnosis on imbalanced exosomal data via Exo-LCClassifier

in Computational Genomics

Siyu Zhan
Hao Yu
Shuang Liu
Ke Qin
Lu Guo

Frontiers in Genetics

doi 10.3389/fgene.2025.1583081

2,141 views
1 citation

Original Research

Published on 30 Apr 2025

Applying the algorithm for Proven and young in GWAS Reveals high polygenicity for key traits in Nellore cattle

in Livestock Genomics

Adebisi R. Ogunbawo
Jorge Hidalgo
Henrique A. Mulim
Eula R. Carrara
Henrique T. Ventura
Nadson O. Souza
Daniela Lourenco
Hinayah R. Oliveira

Frontiers in Genetics

doi 10.3389/fgene.2025.1549284

3,923 views
8 citations

Original Research

Published on 29 Apr 2025

Chromosome-level draft genome assembly of Hypomesus nipponensis reveals transposable element expansion reshaping the genome structure

in Livestock Genomics

Chenzhao Zhu
Youyi Kuang
Zhe Li
Fujiang Tang

Frontiers in Genetics

doi 10.3389/fgene.2025.1502681

2,334 views

Original Research

Published on 29 Apr 2025

Artificial intelligence meets genomic selection: comparing deep learning and GBLUP across diverse plant datasets

in Statistical Genetics and Methodology

Abelardo Montesinos-López
Osval A. Montesinos-López
Sofia Ramos-Pulido
Brandon Alejandro Mosqueda-González
Edgar Alejandro Guerrero-Arroyo
José Crossa
Rodomiro Ortiz

Frontiers in Genetics

doi 10.3389/fgene.2025.1568705

6,206 views
9 citations

Original Research

Published on 29 Apr 2025

Constructing ancestral recombination graphs through reinforcement learning

in Computational Genomics

Mélanie Raymond
Marie-Hélène Descary
Cédric Beaulac
Fabrice Larribe

Frontiers in Genetics

doi 10.3389/fgene.2025.1569358

2,604 views

Original Research

Published on 29 Apr 2025

The identification of a blood circular RNA signature that differentiates Chikungunya virus infection

in Computational Genomics

Xue Bai
Hanlin Yan
Guoxia Wen
Shaoxun Yuan
Wanjun Gu

Frontiers in Genetics

doi 10.3389/fgene.2025.1602177

2,697 views

Original Research

Published on 29 Apr 2025

Potential common mechanisms between primary Sjögren’s syndrome and Hashimoto’s thyroiditis: a public databases-based study

in Computational Genomics

Yanjun Lin
Shupin Tang
Yan Lin
Rihui Wang
Yifeng Xing
Zonghe Xu
Yan Li
Qingxia Fang
Wenwei Wei
Dong Wu

Frontiers in Genetics

doi 10.3389/fgene.2025.1520332

3,415 views
1 citation

Original Research

Published on 28 Apr 2025

Single-cell transcriptomic construction of fibroblast score for analysis of immune infiltration in primary and metastatic ovarian cancer

in Computational Genomics

Qian Guo
Hongmei Ding
Qinlin Zheng

Frontiers in Genetics

doi 10.3389/fgene.2025.1549541

2,252 views

Original Research

Published on 28 Apr 2025

Skin transcriptomic and selection signature analyses identify ASIP as a key gene in cattle coat color determination

in Livestock Genomics

Xin Wang
Longxin Xu
Di Zhou
Yanli Lv
Junda Wu
Yuanfeng Zhao
Mengmeng Ni
Wenzhang Zhou
Kaikai Zhang
Hua Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1577647

2,699 views
2 citations

Mini Review

Published on 28 Apr 2025

Frontier progress and translational challenges of pluripotent differentiation of stem cells

in Stem Cell Research

Zhengbing Su
Hui Dong
Xiang Fang
Wenli Zhang
Hong Duan

Frontiers in Genetics

doi 10.3389/fgene.2025.1583391

5,661 views
6 citations

Original Research

Published on 28 Apr 2025

Shared genetic features inference among hypoxia-ischemia diseases in the presence of heterogenous omics data based on a novel risk assessment method

in Computational Genomics

Yifan Zhang
Jianfeng Liu
Zhuoma Basang
Qianxun Yang
Hongce Chen
Shuo Chen
Shaogang Li
Changgui Lei
Mingyan Fang
Huanhuan Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1587854

4,286 views
2 citations

Original Research

Published on 28 Apr 2025

Exploring WNT pathway dysregulation in serrated colorectal cancer for improved diagnostic and therapeutic strategies

in Computational Genomics

Fengzhi Zhu
Helen Hoi Ning Yan
Yin Tong
Yueliang Zhao

Frontiers in Genetics

doi 10.3389/fgene.2025.1586867

2,441 views
1 citation

Original Research

Published on 28 Apr 2025

Integrative analysis of DNA methylation, RNA sequencing, and genomic variants in the cancer genome atlas (TCGA) to predict endometrial cancer recurrence

in Human and Medical Genomics

Jin Hwa Hong
Yung Taek Ouh
Sohyeon Jeong
Yoonji Oh
Hyun Woong Cho
Jae Kwan Lee
Hayeon Kim
Chungyeul Kim
Sanghyun Roh
Eun Na Kim

Frontiers in Genetics

doi 10.3389/fgene.2025.1569122

4,456 views
3 citations

Original Research

Published on 25 Apr 2025

Genetic diversity and novel haplotypes of Apis mellifera jemenitica on the Arabian Peninsula: insights from mtDNA markers

in Evolutionary and Population Genetics

Mohammed Alsharhi
Ahmad Al-Ghamdi
Maged Ahmed Al-Garadi
Mohamed Alburaki

Frontiers in Genetics

doi 10.3389/fgene.2025.1532988

2,443 views
1 citation

Original Research

Published on 25 Apr 2025

Relationship of VDR and VDBP gene polymorphisms with sepsis susceptibility and prognosis

in Genetics of Common and Rare Diseases

Chan Lian
Kangtai Ying
Haiyan Shao
Haiting Gu
Wenwei Mao

Frontiers in Genetics

doi 10.3389/fgene.2025.1590750

1,853 views

Original Research

Published on 25 Apr 2025

A rare germline mutation reverses the suppressive effect of GPC5 thereby promoting lung adenocarcinoma development and tumorigenesis

in Cancer Genetics and Oncogenomics

Zhifa Zheng
Lina Zhao
Sen Zhao
Zhihong Wu
Nan Wu

Frontiers in Genetics

doi 10.3389/fgene.2025.1582504

2,565 views

Original Research

Published on 25 Apr 2025

Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development

in Neurogenomics

Guijiao Huang
Xin Dong
Xiaojiao Shao
Mengping Wu
Shan Gao
Yixuan Wang
Xinying Guan

Frontiers in Genetics

doi 10.3389/fgene.2025.1556498

1,884 views
2 citations

16,556 articles

articles

Development and validation of a polygenic risk score for height in a Greek cohort: Association with blood pressure measurements

In vitro 3D modeling of colorectal cancer: the pivotal role of the extracellular matrix, stroma and immune modulation

Radiomic features and tumor immune microenvironment associated with anaplastic lymphoma kinase-rearranged lung adenocarcinoma and their prognostic value

Identification of potential crucial genes and mechanisms associated with metabolically unhealthy obesity based on the gene expression profile

Leveraging long-read sequencing technologies for pharmacogenomic testing: applications, analytical strategies, challenges, and future perspectives

Impact of nonsynonymous single nucleotide polymorphisms in PROCR gene on protein stability and thrombotic risk: a molecular dynamic approach

Genetic architecture of thermotolerance traits in beef cattle: a novel integration of SNP and breed-of-origin effects

High-precision lung cancer subtype diagnosis on imbalanced exosomal data via Exo-LCClassifier

Applying the algorithm for Proven and young in GWAS Reveals high polygenicity for key traits in Nellore cattle

Chromosome-level draft genome assembly of Hypomesus nipponensis reveals transposable element expansion reshaping the genome structure

Artificial intelligence meets genomic selection: comparing deep learning and GBLUP across diverse plant datasets

Constructing ancestral recombination graphs through reinforcement learning

The identification of a blood circular RNA signature that differentiates Chikungunya virus infection

Potential common mechanisms between primary Sjögren’s syndrome and Hashimoto’s thyroiditis: a public databases-based study

Single-cell transcriptomic construction of fibroblast score for analysis of immune infiltration in primary and metastatic ovarian cancer

Skin transcriptomic and selection signature analyses identify ASIP as a key gene in cattle coat color determination

Frontier progress and translational challenges of pluripotent differentiation of stem cells

Shared genetic features inference among hypoxia-ischemia diseases in the presence of heterogenous omics data based on a novel risk assessment method

Exploring WNT pathway dysregulation in serrated colorectal cancer for improved diagnostic and therapeutic strategies

Integrative analysis of DNA methylation, RNA sequencing, and genomic variants in the cancer genome atlas (TCGA) to predict endometrial cancer recurrence

Genetic diversity and novel haplotypes of Apis mellifera jemenitica on the Arabian Peninsula: insights from mtDNA markers

Relationship of VDR and VDBP gene polymorphisms with sepsis susceptibility and prognosis

A rare germline mutation reverses the suppressive effect of GPC5 thereby promoting lung adenocarcinoma development and tumorigenesis

Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development