Frontiers in Immunology

Original Research

Published on 03 Dec 2025

Development and validation of a machine learning-driven mitochondrial gene signature for the diagnosis of breast cancer

in Cancer Immunity and Immunotherapy

Siyu Tong
Fei Teng
Weijia Kong
Xuanhe Tian
Dong Guo
Meng Liu
Jian Ren

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712089

901 views

Review

Published on 03 Dec 2025

Dual role of complement in neuronal repair

in Multiple Sclerosis and Neuroimmunology

Agnieszka Lukomska
Peter Ciesielski
Mariusz Z. Ratajczak
Magdalena Kucia

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712452

637 views

Review

Published on 03 Dec 2025

Structural and dynamic properties of IL1 receptors

in Cytokines and Soluble Mediators in Immunity

J. V. Zhukova
J. A. Lopatnikova
S. V. Sennikov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1714624

507 views

Original Research

Published on 03 Dec 2025

Single-cell RNA sequencing reveals heterogeneity among AT2 epithelial cells in the lung adenocarcinoma microenvironment

in Cancer Immunity and Immunotherapy

Zimeng Cao
Xuefeng Bai
Jing Li
Jinru Cai
Gang Cao
Yuncai Xiao
Wei Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1735459

675 views

Original Research

Published on 03 Dec 2025

Synthetic antimicrobial peptide LD4-PP protects the host against E. coli-induced cell death

in Molecular Innate Immunity

Soumitra Mohanty
John Kerr White
Yundi Yin
Taj Muhammad
Isak Demirel
Adam A. Strömstedt
Sunithi Gunasekera
Natalia Ferraz
Ulf Göransson
Annelie Brauner

Frontiers in Immunology

doi 10.3389/fimmu.2025.1705805

854 views

Correction

Published on 03 Dec 2025

Correction: Leukocyte dynamics in Cynomolgus monkeys following heterotopic heart allotransplantation under costimulation pathway blockade

in Alloimmunity and Transplantation

Gheorghe Braileanu
Agnes M. Azimzadeh
Tianshu Zhang
Lars Burdorf
Richard N. Pierson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1732897

356 views

Correction

Published on 03 Dec 2025

Correction: Platelet alloimmunization in transfusion-dependent thalassemia patients from Southern China (2014-2023)

in Alloimmunity and Transplantation

Frontiers Production Office

Frontiers in Immunology

doi 10.3389/fimmu.2025.1755852

220 views

Review

Published on 03 Dec 2025

Recent advances in targeting the cGAS–STING pathway for immunotherapy in orthopedic diseases

in Cancer Immunity and Immunotherapy

Feipeng Wu
Shan Hui
Dapeng Li
Guoqing Pan
Wenchao Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726423

1,137 views

Review

Published on 03 Dec 2025

Circadian clocks and adaptive immune function: from mechanisms to therapeutic applications

in Systems Immunology

Aleksandra Szredzka
Anna Chwastowicz
Joanna Pergoł
Paweł Matryba

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697854

931 views

Original Research

Published on 03 Dec 2025

IL-10 and IL-2R as combined predictors of intravenous immunoglobulin resistance in Kawasaki disease: a retrospective cohort study

in Cytokines and Soluble Mediators in Immunity

Hui-Ying Wang
Sun Chen
Chun Zhang
Ji-Hong Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646502

570 views

Original Research

Published on 03 Dec 2025

Decoding ascitic immunological niches with multi-modal machine learning reveals prognostic and chemoresistant determinants in ovarian cancer

in Cancer Immunity and Immunotherapy

Lin Yang
Tianhui He
Jing Wang
Xiaolan Zhang
Lin Zeng
Qinkun Sun
Yuelin Song
Yufei Nie
Xinran Gao
Chunliang Shang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698793

557 views

Original Research

Published on 03 Dec 2025

Variant-adapted COVID-19 vaccine boosters enhance humoral immunity and limit IgG4 accumulation in solid cancer patients

in Vaccines and Molecular Therapeutics

Chiara Piubelli
Matteo Valerio
Donato Zipeto
Elisa Orlandi
Sara Caldrer
Francesco Rizzolo
Katrine Barbero
Elisabetta Vezzelli
Natasha Gianesini
Sonia Zamboni

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699177

761 views

Mini Review

Published on 03 Dec 2025

Beyond the joints: mechanistic insights and multidisciplinary strategies for spondyloarthritis-associated uveitis

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Shuyue Pan
Ling Xiang
Zhi Cao
Zhi Yang
Rui-Juan Cheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715107

527 views

Review

Published on 03 Dec 2025

COVID-19 vaccine-induced autoimmune hyperthyroidism: Graves’ disease

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Avaniyapuram Kannan Murugan
Ali S. Alzahrani

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699210

4,598 views

Clinical Trial

Published on 03 Dec 2025

Combination immunotherapy and anti-angiogenic therapy shows promising efficacy in NSCLC patients with recurrent or refractory brain metastases and negative driver genes

in Cancer Immunity and Immunotherapy

Liwei Sun
Bonian Chen
Bin Wang
Jinduo Li
Lin Li
Caijuan Tian
Hongbo Zhang
Pengfei Liu
Xiaomin Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684759

786 views

Brief Research Report

Published on 03 Dec 2025

T-cell receptors that are k-binding have defined sequence features

in T Cell Biology

Hyunjin Park
Jonathan Krog
Brandon Carter
Pallavi A. Balivada
Emily M. Pogue
Samyuktha Anand
Michael E. Birnbaum
David K. Gifford

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621201

2,092 views

Original Research

Published on 03 Dec 2025

Causal inference of CLEC5A and ISG20 in atherosclerosis: integrating Mendelian randomization and eQTL evidence

in Inflammation

Ya Zhang
Qian Tian
Yuan Zhu
Tianhui Wang
Yongchao Yu
Lan Wang
Lijuan Shao
Xiangang Mo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1644135

562 views

Case Report

Accepted on 02 Dec 2025

TAFRO syndrome requiring combined IL 6 and IL 1 inhibition: a case report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Ahmad Wael Sultan
Eva Grießhammer
Carl Hinrichs
Lars Trenkmann
Ilske Oschlies
Leif Gunnar Hanitsch
Haibel Hildrun
Thomas Schneider
Rasmus Leistner

Frontiers in Immunology

253 views

Original Research

Accepted on 02 Dec 2025

Functional physiological, psychological, and biochemical Reactivity to Socially Evaluated Cold Pressor Test in Hereditary Angioedema Patients (FRoSEn)

in Inflammation

Beatrice De Maria
Luca Ranucci
Clara Gino
Azzurra Cesoni Marcelli
Lorenza Chiara Zingale
Aida Zulueta
Laura Adelaide Dalla Vecchia
Alessandra Gorini
Francesca Perego

Frontiers in Immunology

244 views

Original Research

Accepted on 02 Dec 2025

Hepatic arterial infusion plus systemic chemotherapy, lenvatinib and PD- (L)1 inhibitors versus gemcitabine and cisplatin plus PD-(L)1 inhibitors in advanced intrahepatic cholangiocarcinoma

in Cancer Immunity and Immunotherapy

Huazhong Guo
YeXing Huang
Na Liu
MinKe He
Zhicheng Lai
Shi Ming
Qijiong Li

Frontiers in Immunology

123 views

Original Research

Accepted on 02 Dec 2025

Comparison of Chimeric Mouse-Human and Humanized Anti-CD25 Monoclonal Antibodies for Steroid-Refractory Acute Graft-Versus-Host Disease

in Cancer Immunity and Immunotherapy

Xinhui Zheng
Yunxia Zhou
Ni Lu
Yawei Zheng
YIGENG CAO
Weihua Zhai
Jialin Wei
Donglin Yang
Rongli Zhang
Aiming Pang

Frontiers in Immunology

174 views

Original Research

Accepted on 02 Dec 2025

Single-cell RNA sequencing unraveled immune-related expression heterogeneity and lymphoid cell development dysregulation in childhood asthma

in Inflammation

Danying Zhu
Guang Li
Lang Yuan
Zeyu Zeng
Na Dong
Chao Wang
Chen MIng
Lijian Xie
Guohui Ding
Libing Shen

Frontiers in Immunology

132 views

Brief Research Report

Accepted on 02 Dec 2025

Phlebotomus duboscqi gut microbiota dynamics in the context of Leishmania infection

in Microbial Immunology

Kristina Tang
Yue Zhang
Claudio Roberto Meneses
Luana A. Rogerio
Laura Willen
Eva Iniguez
Shaden Kamhawi
Jesus G. Valenzuela
Fabiano Oliveira
Pedro Cecilio

Frontiers in Immunology

158 views

Original Research

Accepted on 02 Dec 2025

The immunomodulating effect of palmitoylethanolamide on human myeloid dendritic cells and its possible impact on Alzheimer's disease

in Multiple Sclerosis and Neuroimmunology

Iliana Piccolino
Filomena Iannuzzi
Ludovica Lionetti
Benedetta Mazzonello
Fabrizio Piras
Nerisa Banaj
Valeria Barreca
Valentina Arezzini
Paola Bossù

Frontiers in Immunology

310 views

48,462 articles

articles

Development and validation of a machine learning-driven mitochondrial gene signature for the diagnosis of breast cancer

Dual role of complement in neuronal repair

Structural and dynamic properties of IL1 receptors

Single-cell RNA sequencing reveals heterogeneity among AT2 epithelial cells in the lung adenocarcinoma microenvironment

Synthetic antimicrobial peptide LD4-PP protects the host against E. coli-induced cell death

Correction: Leukocyte dynamics in Cynomolgus monkeys following heterotopic heart allotransplantation under costimulation pathway blockade

Correction: Platelet alloimmunization in transfusion-dependent thalassemia patients from Southern China (2014-2023)

Recent advances in targeting the cGAS–STING pathway for immunotherapy in orthopedic diseases

Circadian clocks and adaptive immune function: from mechanisms to therapeutic applications

IL-10 and IL-2R as combined predictors of intravenous immunoglobulin resistance in Kawasaki disease: a retrospective cohort study

Decoding ascitic immunological niches with multi-modal machine learning reveals prognostic and chemoresistant determinants in ovarian cancer

Variant-adapted COVID-19 vaccine boosters enhance humoral immunity and limit IgG4 accumulation in solid cancer patients

Beyond the joints: mechanistic insights and multidisciplinary strategies for spondyloarthritis-associated uveitis

COVID-19 vaccine-induced autoimmune hyperthyroidism: Graves’ disease

Combination immunotherapy and anti-angiogenic therapy shows promising efficacy in NSCLC patients with recurrent or refractory brain metastases and negative driver genes

T-cell receptors that are k-binding have defined sequence features

Causal inference of CLEC5A and ISG20 in atherosclerosis: integrating Mendelian randomization and eQTL evidence

TAFRO syndrome requiring combined IL 6 and IL 1 inhibition: a case report

Functional physiological, psychological, and biochemical Reactivity to Socially Evaluated Cold Pressor Test in Hereditary Angioedema Patients (FRoSEn)

Hepatic arterial infusion plus systemic chemotherapy, lenvatinib and PD- (L)1 inhibitors versus gemcitabine and cisplatin plus PD-(L)1 inhibitors in advanced intrahepatic cholangiocarcinoma

Comparison of Chimeric Mouse-Human and Humanized Anti-CD25 Monoclonal Antibodies for Steroid-Refractory Acute Graft-Versus-Host Disease

Single-cell RNA sequencing unraveled immune-related expression heterogeneity and lymphoid cell development dysregulation in childhood asthma

Phlebotomus duboscqi gut microbiota dynamics in the context of Leishmania infection

The immunomodulating effect of palmitoylethanolamide on human myeloid dendritic cells and its possible impact on Alzheimer's disease