Frontiers in Immunology | Cytokines and Soluble Mediators in Immunity

Original Research

Published on 30 May 2025

Markers of T cell activation and exhaustion in plasma are associated with persistent symptoms up to 18 months following mild SARS-CoV-2 infection

in Cytokines and Soluble Mediators in Immunity

Thor Ueland
Rebecca Jane Cox
Annika E. Michelsen
Elisabeth Berg Fjelltveit
Kari Otterdal
Tuva Dahl
Fan Zhou
Rebecca Elyanow
Pål Aukrust
Bjørn Blomberg

Frontiers in Immunology

doi 10.3389/fimmu.2025.1578208

657 views

Original Research

Accepted on 28 May 2025

Inhibition of the Na + -glucose transporter SGLT2 reduces glucose uptake and IFNg release from activated human CD4 + T cells

in Cytokines and Soluble Mediators in Immunity

Zhe Jin
Hayama Hammoud
Amol K Bhandage
Stasini Koreli
Azazul Islam Chowdhury
Peter Bergstein
Bryndis Birnir

Frontiers in Immunology

doi 10.3389/fimmu.2025.1576216

150 views

Original Research

Published on 28 May 2025

Autophagy crosstalk with the immune microenvironment in chronic myeloid leukemia and serves as a biomarker for diagnosis and progression

in Cytokines and Soluble Mediators in Immunity

Fangmin Zhong
Fangyi Yao
Jing Liu
Qun Fang
Xiajing Yu
Bo Huang
Xiaozhong Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1570903

590 views

Original Research

Published on 27 May 2025

Endogenous SLPI contributes to the regulation of inflammatory responses in peritoneal macrophages by modulating MMP-9 production

in Cytokines and Soluble Mediators in Immunity

Mariia Tyshchenko
Natalia Pocałuń
Patrycja Kwiecińska
Joanna Cichy
Mieszko M. Wilk
Ewa Oleszycka

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563845

936 views

Original Research

Published on 26 May 2025

Developing an in vitro osteochondral micro-physiological system for modeling cartilage-bone crosstalk in arthritis

in Cytokines and Soluble Mediators in Immunity

Kyra W. Y. Smith
Stephanie L. Fung
Hsin-Fang Wu
Irene Chiesa
Giovanni Vozzi
Carmelo De Maria
Riccardo Gottardi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1495613

1,561 views

Original Research

Published on 23 May 2025

TSLP pretreatment inhibits M1 macrophage polarization and attenuates LPS-induced iNKT cell-dependent acute lung injury

in Cytokines and Soluble Mediators in Immunity

Ting Zhou
Ziyao Zhang
Yawen Zhan
Meiying Wang
Mi Wu
Xiufang Weng
Younian Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1583235

1,038 views

Review

Accepted on 21 May 2025

Astrocyte-Microglia Crosstalk in Subarachnoid Hemorrhage: Mechanisms and Treatments

in Cytokines and Soluble Mediators in Immunity

Kaibo Yu
Wenhua Yu
Ding Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1547858

117 views

General Commentary

Published on 20 May 2025

Commentary: Guselkumab binding to CD64+ IL-23–producing myeloid cells enhances potency for neutralizing IL-23 signaling

in Cytokines and Soluble Mediators in Immunity

Giulia Valdiserra
Clelia Di Salvo
Matteo Fornai
Luca Antonioli

Frontiers in Immunology

doi 10.3389/fimmu.2025.1604337

999 views

Original Research

Published on 08 May 2025

Evaluation of humoral and cellular immune responses in healthcare workers with varying levels of SARS-CoV-2 exposure: effects of CoronaVac vaccination followed by heterologous booster

in Cytokines and Soluble Mediators in Immunity

Shayane Martins Rodrigues Gomes
Marcelo Ribeiro-Alves
Roberto Stefan de Almeida Ribeiro
Andréia Carolinne de Souza Brito
Vinicius da Cunha Lisboa
Samara Galdino de Azevedo
Jeane de Souza Nogueira
Leda dos Reis Castilho
Luís Cristóvão Sobrino Pôrto
Silvia Amaral Gonçalves da Silva

Frontiers in Immunology

doi 10.3389/fimmu.2025.1576430

1,453 views

Original Research

Published on 06 May 2025

Characterization and correlation analysis of oral NET markers and inflammatory factor levels in patients after orthodontic treatment: a pilot study

in Cytokines and Soluble Mediators in Immunity

Qian Liu
Axian Wang
Donghui Guo
Houzhuo Luo
Shishu Fang
Zhixin Song
Yi Wen
Fang Jin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1490637

723 views

Original Research

Published on 02 May 2025

Apolipoprotein M expression modifies the sphingolipid landscape in murine blood and lymph

in Cytokines and Soluble Mediators in Immunity

Victoria A. Blaho
Joshua T. Minyard

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572959

1,532 views

Editorial

Published on 01 May 2025

Editorial: The immunological events of macrophages in the course of sepsis

in Cytokines and Soluble Mediators in Immunity

Shiyun Wu
Xu Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1610868

756 views

Review

Published on 01 May 2025

The effects of interleukin-21 in the biology of transplant rejection

in Cytokines and Soluble Mediators in Immunity

Xiandong Zeng
Yixiao Pan
Qiang Xia
Kang He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1571828

1,251 views

Original Research

Published on 28 Apr 2025

Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response

in Cytokines and Soluble Mediators in Immunity

Jorgo Lika
James A. Votava
Rupsa Datta
Carlos A. Mellado Fritz
Aleksandr M. Kralovec
Frances M. Smith
Anna Huttenlocher
Melissa C. Skala
Jing Fan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572927

1,613 views

Original Research

Published on 17 Apr 2025

Concomitant autoimmunity and late cancers in adult-onset immunodeficiency due to neutralizing anti-IFN-γ autoantibodies

in Cytokines and Soluble Mediators in Immunity

Wan-Ting Tsai
Chih-Yun Cheng
Hsin-Yun Sun
Bei-Chia Guo
Ying-Chieh Chiang
Chiao-Feng Cheng
Yi-Hua Pan
Un-In Wu
Jann-Tay Wang
Wang-Huei Sheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1526439

1,673 views

Original Research

Published on 14 Apr 2025

Impact of alcohol consumption on outcomes and potential of immune biomarkers for postoperative complications in trauma patients

in Cytokines and Soluble Mediators in Immunity

Mohammad Majd Hammour
Yelda Anuk
Regina Breinbauer
Romina H. Aspera-Werz
Yuxuan Xin
Guanqiao Chen
Tina Histing
Sabrina Ehnert
Andreas K. Nüssler
Stefan Döbele

Frontiers in Immunology

doi 10.3389/fimmu.2025.1492288

1,279 views