Frontiers in Immunology | Molecular Innate Immunity

Original Research

Published on 31 Oct 2025

Single-cell and spatial transcriptomics integration reveals FAM49B promotes tumor-associated macrophages polarization in colorectal cancer via the MK pathway

in Molecular Innate Immunity

Tianyu Liu
Quchen Ding
Jin Gou
Chen Lu
Xingming Lu
Jiatong Chen
Yiming E.
Lianhong Li
Chongguo Zhang
Xiaojuan Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682637

3,962 views

Original Research

Published on 30 Oct 2025

Lactylation-related gene AKR1A1 contributes to osteoporosis via metabolic–immune regulation: evidence from multi-omics integration, single-cell transcriptomics, and in vitro validation

in Molecular Innate Immunity

Zichen Shao
Qinqin Deng
Ling Cheng
Jianfeng Wu
Weikang Sun
Weidong Liang
Huanan Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680305

3,271 views
1 citation

Original Research

Published on 30 Oct 2025

Deficiency of HMGN2 enhances antibacterial activity of macrophages by promoting H3 histone modification-mediated CD14/iNOS expression

in Molecular Innate Immunity

Zhen Yang
Xiao Zhang
Chaoqun Liu
Ning Huang
Yan Teng
Junming Miao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621440

1,553 views

Original Research

Published on 29 Oct 2025

Necrosis by sodium overload-associated genes TRPM4 and SLC9A1: biological roles and clinical implications in breast cancer progression

in Molecular Innate Immunity

Yingze Zhu
Yaxin Guo
Yanlin Su
Zhuoqi Zhang
Yige Lu
Xianghan Zhang
Hui Pang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1623511

2,199 views

Original Research

Published on 28 Oct 2025

The peptide genomic therapy increases antibacterial immunity and survival in sepsis by reprograming the gene orthologs of human immunodeficiencies in the spleen and lungs

in Molecular Innate Immunity

Huan Qiao
Jozef Zienkiewicz
Yan Liu
Jacek Hawiger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1635081

2,189 views
1 citation

Mini Review

Published on 24 Oct 2025

Endoplasmic reticulum stress and unfolded protein response in immune cell function

in Molecular Innate Immunity

Goshi Matsushima
Yuhki Yanase
Tadashi Nakagawa
Mitsuhiro Goda
Koichiro Ozawa
Toru Hosoi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694102

2,849 views
1 citation

Original Research

Published on 23 Oct 2025

Expression of NEAT1 induced by influenza virus infection is regulated by activated STAT3 and contributes to STAT3-mediated antiviral immunity

in Molecular Innate Immunity

Rongrong Gu
Erying Xu
Jingjie Hong
Liqing Fan
Shasha Liu
Ji-Long Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693884

2,129 views

Brief Research Report

Published on 23 Oct 2025

Dual-functional cerium oxide nanoparticles with antioxidant and DNase I activities to prevent and degrade neutrophil extracellular traps

in Molecular Innate Immunity

Hachem Dich
Ramy Abou Rjeily
Gabriela Rath
Mathéo Berthet
Bénédicte Dayde-Cazals
Jean-François Berret
Eduardo Angles-Cano

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693809

1,935 views
1 citation

Review

Published on 22 Oct 2025

Innate immunity in tumors: roles and therapeutic targets

in Molecular Innate Immunity

Songze Leng
Yuyue Ren
Yaoyao Tian
Weiwei Zhao
Yue Mou
Xingyu Chen
Hong Zhou
Wei Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689714

2,435 views

Original Research

Published on 21 Oct 2025

Phospholipase D1 is a critical mediator of neutrophil extracellular trap formation and venous thrombosis

in Molecular Innate Immunity

Ryosuke Aihara
Masatomo Takahashi
Kenji Morino
Keisuke Matsubara
Kazufumi Kunimura
Akihiko Nishikimi
Yoshihiro Izumi
Takeshi Bamba
Yoshinori Fukui
Takehito Uruno

Frontiers in Immunology

doi 10.3389/fimmu.2025.1666184

2,184 views

Original Research

Published on 16 Oct 2025

TNF-α-mediated downregulation of CD36 and phagocytic impairment of alveolar macrophages via upregulation of ADAM17 in asthma

in Molecular Innate Immunity

Xingyue Liu
Ya Li
Feifei Shang
Minzhu Niu
Jiaqi Yan
Minyu Xie
Xiangnan Tao
Han Huang
Wenwen Wu
Shu Dong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663513

1,785 views

Review

Published on 16 Oct 2025

From mechanisms to therapies: the multifaceted roles of guanylate-binding protein 2 in immunity, cancer, and beyond

in Molecular Innate Immunity

Wenqi Cui
Tianlu Wang
Juan Feng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708319

2,064 views
1 citation

Review

Published on 16 Oct 2025

Immune cell regulatory networks in chronic obstructive pulmonary disease: mechanistic analysis from innate to adaptive immunity

in Molecular Innate Immunity

Hui Li
Yingqi Wang
Hongxia Duan
Yidie Bao
Xinliao Deng
Yucheng He
Qian Gao
Peijun Li
Xiaodan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651808

5,425 views
2 citations

Original Research

Published on 15 Oct 2025

Human colon stem cells are the predominant epithelial responders to bacterial antigens

in Molecular Innate Immunity

Maaike H. De Vries
Claartje A. Meddens
Hemme J. Hijma
Anne-Claire Berrens
Suze A. Jansen
Berend A. P. Kooiman
Scott Snapper
Hans Clevers
Michal Mokry
Ewart W. Kuijk

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677943

2,696 views
1 citation

Original Research

Published on 14 Oct 2025

Integrative modeling of malignant epithelial programs in EGFR-mutant LUAD via single-cell transcriptomics and multi-algorithm machine learning

in Molecular Innate Immunity

Weiran Zhang
Lin Tan
Qiuqiao Mu
Han Zhang
Daqiang Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661679

2,716 views
1 citation

Review

Published on 14 Oct 2025

Luteolin as a multifaceted immunomodulator: insights into its effects on diverse immune cell populations and therapeutic implications

in Molecular Innate Immunity

Xiaolan Wang
Junbo Zhao
Ying Li
Sujun Gao
Long Su

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621367

3,855 views
3 citations

Original Research

Published on 13 Oct 2025

Fibroblast heterogeneity and FN1-mediated signaling in endometriosis revealed by single-cell and spatial transcriptomics

in Molecular Innate Immunity

Wenwen Shao
Hongmei Ju
Zhikai Xiahou
Sheng Fang
Rugen Yan
Chunyan Li
Yuan Xu
Pingping Cai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680849

4,451 views

Mini Review

Published on 09 Oct 2025

Roles of tumor-associated macrophages in triple-negative breast cancer progression

in Molecular Innate Immunity

Tianhai Wu
Yuling Liao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677363

4,130 views

Review

Published on 09 Oct 2025

Unveiling CD177: a key player in tumors, autoimmune diseases, and inflammatory disorders

in Molecular Innate Immunity

Dongmei Yang
Xiaobin Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653587

4,433 views
1 citation

Brief Research Report

Published on 08 Oct 2025

Optimizing monocyte-derived immune cell cultures: comparing xeno-free and xenogeneic conditions

in Molecular Innate Immunity

Nora Marek
Anette S. B. Wolff
Harsh N. Dongre
Salwa Suliman

Frontiers in Immunology

doi 10.3389/fimmu.2025.1589553

3,039 views
1 citation

Original Research

Published on 08 Oct 2025

Integrating bioinformatics and machine learning analyses to identify immune-related secretory proteins and therapeutic small-molecule drugs in calcific aortic valve disease with type 2 diabetes

in Molecular Innate Immunity

Xiang Zhang
Jiahui Wang
Qian Hu
Bangyu Guo
Mengjie Hu
Xiaobo Yu
Shunbo Wei
Qiujie Luo
Yuqing Zhang
Shentao Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634655

2,520 views

Original Research

Published on 07 Oct 2025

Deciphering macrophage differentiation and cell death dynamics in heart failure: a single-cell sequencing odyssey

in Molecular Innate Immunity

Jin Wei
Yao Sun
Bao-xi Qu
Xin-xin Duan
Li-hong Yan
Wei An
Kun-lun Yin
Shui-yun Wang
Yan-hai Meng
Lei Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1604226

3,863 views

Original Research

Published on 03 Oct 2025

The interplay between hormonal vitamin D and lipopolysaccharide signaling on human neutrophil transcriptional responses

in Molecular Innate Immunity

Aiten Ismailova
Reyhaneh Salehi-Tabar
Nailya Ismailova
Olivia Dumas
James Saliba
Volker Blank
John H. White

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683913

2,903 views

Original Research

Published on 02 Oct 2025

Dual roles of in situ generated HSP70 in antigen delivery and immunoregulation

in Molecular Innate Immunity

Xinliang Kang
Zhuofan Li
Jayachandra Reddy Nakkala
Yibo Li
Labone Akter
Yiwen Zhao
Xinyuan Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638948

2,133 views