Frontiers in Immunology | Viral Immunology

Original Research

Published on 16 Jul 2025

Comprehensive N-glycosylation profiling of recombinant spike S1 protein from the wild-type SARS-CoV-2 and its variants

in Viral Immunology

Yao Peng
Tian-Tian Tong
Qiu-Yu Deng
Lee-Fong Yau
Jia-Qi Qiu
Qing Zhao
Jia-Qi Wu
Zhi-Qiang Xin
Man-Ci Guan
Yue Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1592142

3,085 views
1 citation

Original Research

Published on 11 Jul 2025

Granulocyte colony-stimulating factor protects against acute systemic alphavirus disease in a type I IFN-dependent manner

in Viral Immunology

Muddassar Hameed
Pallavi Rai
Md Shakhawat Hossain
Andrea Daamen
Peter E. Lipsky
James Weger-Lucarelli

Frontiers in Immunology

doi 10.3389/fimmu.2025.1606053

3,190 views
2 citations

Editorial

Published on 10 Jul 2025

Editorial: Immune correlates of protection: Insight into microbial co-infection with special emphasis on influenza-Streptococcus pneumoniae superinfection

in Viral Immunology

Tarani Kanta Barman
Avijit Dutta
Heather W. Stout-Delgado

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654821

1,909 views

Original Research

Published on 10 Jul 2025

Q221K mutation in VP2 drives antigenic shift of infectious bursal disease virus

in Viral Immunology

Haifeng Xiong
Jiayan Wu
Quan Xie
Tuofan Li
Zhimin Wan
Aijian Qin
Jianqiang Ye
Hongxia Shao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600371

2,842 views
3 citations

Original Research

Published on 10 Jul 2025

Patterns of inflammation and immune activation by coreceptor use in people living with HIV-1

in Viral Immunology

Francisco Xavier Guerra-Castillo
Sandra Pinto-Cardoso
Santiago Ávila-Ríos
Monserrat Chávez-Torres
Amy Peralta-Prado
Carolina González-Torres
Javier Gaytán-Cervantes
Brenda Requena-Benitez
Dafne Díaz-Rivera
Carmen Alaez-Verson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1632287

3,201 views

Original Research

Published on 07 Jul 2025

PD-1 induces autophagy via the PI3K/AKT/FoxO1 pathway to promote infectious bursal disease virus replication

in Viral Immunology

Qiuyu Zhang
Feng Yue
Guopeng Sun
Liwei Jiang
Peng Li
Yanping Zhu
Zhike Liu
Yangzhao Zhu
Ruiyan Niu
Hua He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1585012

3,023 views

Original Research

Published on 04 Jul 2025

CYP1B1 knockout enhanced IFN-γ production is required but not sufficient for protection of cigarette smoke-exposed mice against lethal influenza virus infection

in Viral Immunology

Wenxin Wu
Jeremy S. Alexander
J. Leland Booth
Magdalena Chlebicz
Craig A. Miller
Chao Xu
Susan Kovats
Jordan P. Metcalf

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600025

2,747 views

Original Research

Published on 04 Jul 2025

The salvage therapy utilizing human umbilical cord-derived mesenchymal stem cells for the treatment of critically ill patients with COVID-19

in Viral Immunology

Weiqi Yao
Boran Li
Yingan Jiang
Qiaoyu Yuan
Wenjie Wu
Ruizhen Hou
Qi Qi
Haibo Dong
Yun Zhang
Yu Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1594373

2,860 views

Original Research

Published on 04 Jul 2025

Zika virus induces monocyte recruitment in the immunocompetent adult brain driving chronic inflammation

in Viral Immunology

Josefina Garcia Diaz
Soo-Jeung Park
Lou Legouez
Tina Comlekoglu
Ashley Beck
Chia-Yi Kuan
Young S. Hahn

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597776

3,865 views
1 citation

Original Research

Published on 03 Jul 2025

Age-dependent differences in type I interferon, IL-12 and pro-inflammatory cytokine production by porcine peripheral blood mononuclear cells in response to pseudorabies virus-infected cells

in Viral Immunology

Manon S. C. Claeys
Simon G. A. L. Brabant
Stijn Rosschaert
Cliff Van Waesberghe
Herman W. Favoreel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1596490

2,361 views

Original Research

Published on 01 Jul 2025

STING regulates NETs formation by activating GSDMD in influenza viral pneumonia

in Viral Immunology

Rongrong Huang
Ranran Chen
Lijuan Xing
Lianhao Wu
Wenwen Zhu
Junsong Jing
Ting Zhou
Yueguo Wu
Sheng Zhang
Zhenqiang You

Frontiers in Immunology

doi 10.3389/fimmu.2025.1598902

3,400 views
1 citation

Review

Published on 27 Jun 2025

Virus-host interaction mechanisms in interferon therapy for hepatitis B virus infection: recent advances

in Viral Immunology

Jiebing Zhang
Tao Lou
Minmin Zhu
Chengkang Wang
Kai Gong
Yingping Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1603544

4,981 views
1 citation

Review

Published on 27 Jun 2025

Exploring the genetic basis of Newcastle disease virus in chickens: a comprehensive review

in Viral Immunology

Haile Berihulay
Wei Luo
Ainong Lao
Jian Ji
Manshan Cai
Dingming Shu
Chenglong Luo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1614794

6,085 views
3 citations

Original Research

Published on 26 Jun 2025

Amplification of select autonomous HERV loci and surrounding host gene transcription in monocytes from patients with post-acute sequelae of COVID-19

in Viral Immunology

Hyunmin Koo
Casey D. Morrow

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621657

3,029 views

Review

Published on 26 Jun 2025

Latest advances and prospects in the pathogenesis, animal models, and vaccine research of severe fever with thrombocytopenia syndrome virus

in Viral Immunology

Chenghao Chen
Jiaxuan Li
Yumo Zhou
Yuwen Zhang
Renjin Huang
Yanjun Zhang
Jianhua Li
Keda Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624290

5,207 views
2 citations

Original Research

Published on 26 Jun 2025

EV-A71 invades the central nervous system and affects the blood-brain barrier in a tree shrew model

in Viral Immunology

Wen-Guang Wang
Xuan Wang
Na Li
De-Xuan Kuang
Pin-Fen Tong
Cai-Xia Lu
Yuan-Yuan Han
Xiao-Mei Sun
Jie-Jie Dai
Long-Ding Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1583768

3,639 views
2 citations

Original Research

Published on 24 Jun 2025

RhCMV reactivation in SARS-CoV-2 infected aged rhesus macaques

in Viral Immunology

Jamin W. Roh
Peter A. Barry
Peter W. Hunt
Smita S. Iyer
Barbara L. Shacklett

Frontiers in Immunology

doi 10.3389/fimmu.2025.1616490

1,966 views

Methods

Published on 24 Jun 2025

Applications and insights from continuous dengue virus infection in a stable cell line

in Viral Immunology

M. Jane Morwitzer
Ying Yi Zheng
Heather Friberg
Jeffrey R. Currier

Frontiers in Immunology

doi 10.3389/fimmu.2025.1618650

3,534 views
2 citations

Editorial

Published on 20 Jun 2025

Editorial: Cellular and host immune responses in the context of dual viral infection

in Viral Immunology

Mohamed Mahdi
Vartika Srivastava

Frontiers in Immunology

doi 10.3389/fimmu.2025.1641084

1,474 views

Original Research

Published on 19 Jun 2025

Protection against lethal HAdV-4 challenge in STAT1 mice by novel human monoclonal antibodies

in Viral Immunology

Xinyi Zhang
Zhongge Zhu
Peijie Zhai
Peng Lv
You Yang
Chuanhang Cheng
Busen Wang
Ting Fang
Guanying Zhang
Xiangyang Chi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1613945

2,024 views
1 citation

Original Research

Published on 18 Jun 2025

Evolving fitness and immune escape: a retrospective analysis of SARS-CoV-2 spike protein (2020-2024) using protein language model

in Viral Immunology

Sihua Peng
Leke Lyu
Ludy Registre Carmola
Sachin Subedi
M. H. M. Mubassir
Mohamed A. Bakheet
Justin Bahl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1576414

3,608 views

Original Research

Published on 18 Jun 2025

Antiretroviral therapy initiated during acute infection in women with HIV-1 clade C reduces anti-Tat antibody production and lowers CD8+ T cell activation

in Viral Immunology

Thandeka I. Kubheka
Kewreshini Naidoo
Kavidha Reddy
Thumbi Ndung’u
Nompumelelo P. Mkhwanazi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1564960

2,580 views

Perspective

Published on 18 Jun 2025

CCR5 gene editing and HIV immunotherapy: current understandings, challenges, and future directions

in Viral Immunology

Jia-Wen Wang
Jia-Hui Liu
Jian-Jun Xun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1590690

12,539 views
9 citations

Original Research

Published on 18 Jun 2025

Immunopathological features of highly pathogenic Korean Lineage B PRRSV-2: insights into virulence indicators and host immune responses

in Viral Immunology

Gyeong-Seo Park
Seung-Chai Kim
Hwan-Ju Kim
Chang-Gi Jeong
Sang-Chul Kang
Go-Eun Shin
Seoung-Hee Kim
Hye-Young Jeong
Kyoung-Ki Lee
Sang-Myeong Lee

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599468

3,537 views
2 citations

2,757 articles

articles

Comprehensive N-glycosylation profiling of recombinant spike S1 protein from the wild-type SARS-CoV-2 and its variants

Granulocyte colony-stimulating factor protects against acute systemic alphavirus disease in a type I IFN-dependent manner

Editorial: Immune correlates of protection: Insight into microbial co-infection with special emphasis on influenza-Streptococcus pneumoniae superinfection

Q221K mutation in VP2 drives antigenic shift of infectious bursal disease virus

Patterns of inflammation and immune activation by coreceptor use in people living with HIV-1

PD-1 induces autophagy via the PI3K/AKT/FoxO1 pathway to promote infectious bursal disease virus replication

CYP1B1 knockout enhanced IFN-γ production is required but not sufficient for protection of cigarette smoke-exposed mice against lethal influenza virus infection

The salvage therapy utilizing human umbilical cord-derived mesenchymal stem cells for the treatment of critically ill patients with COVID-19

Zika virus induces monocyte recruitment in the immunocompetent adult brain driving chronic inflammation

Age-dependent differences in type I interferon, IL-12 and pro-inflammatory cytokine production by porcine peripheral blood mononuclear cells in response to pseudorabies virus-infected cells

STING regulates NETs formation by activating GSDMD in influenza viral pneumonia

Virus-host interaction mechanisms in interferon therapy for hepatitis B virus infection: recent advances

Exploring the genetic basis of Newcastle disease virus in chickens: a comprehensive review

Amplification of select autonomous HERV loci and surrounding host gene transcription in monocytes from patients with post-acute sequelae of COVID-19

Latest advances and prospects in the pathogenesis, animal models, and vaccine research of severe fever with thrombocytopenia syndrome virus

EV-A71 invades the central nervous system and affects the blood-brain barrier in a tree shrew model

RhCMV reactivation in SARS-CoV-2 infected aged rhesus macaques

Applications and insights from continuous dengue virus infection in a stable cell line

Editorial: Cellular and host immune responses in the context of dual viral infection

Protection against lethal HAdV-4 challenge in STAT1 mice by novel human monoclonal antibodies

Evolving fitness and immune escape: a retrospective analysis of SARS-CoV-2 spike protein (2020-2024) using protein language model

Antiretroviral therapy initiated during acute infection in women with HIV-1 clade C reduces anti-Tat antibody production and lowers CD8+ T cell activation

CCR5 gene editing and HIV immunotherapy: current understandings, challenges, and future directions

Immunopathological features of highly pathogenic Korean Lineage B PRRSV-2: insights into virulence indicators and host immune responses