ORIGINAL RESEARCH article

Front. Nutr.

Sec. Nutritional Immunology

Volume 12 - 2025 | doi: 10.3389/fnut.2025.1477992

This article is part of the Research TopicNutrition, Inflammation and Oxidative Stress in Obstetrics and GynecologyView all 16 articles

The correlations between serum bone biomarkers and those related to metabolic and hormonal profile, low-grade inflammation and redox balance, in lean and overweight PCOS adolescent girls

Provisionally accepted
Małgorzata MizgierMałgorzata Mizgier1*Veronica SansoniVeronica Sansoni2Barbara WięckowskaBarbara Więckowska3Grażyna Jarząbek-BieleckaGrażyna Jarząbek-Bielecka3Dorota FormanowiczDorota Formanowicz3Witold KędziaWitold Kędzia3Giuseppe BanfiGiuseppe Banfi4Giovanni LombardiGiovanni Lombardi2
  • 1Poznan University of Physical Education, Poznan, Poland
  • 2Laboratory of Experimental Biochemistry and Molecular Biology, Galeazzi Orthopedic Institute (IRCCS), Milan, Lombardy, Italy
  • 3Poznan University of Medical Sciences, Poznań, Greater Poland, Poland
  • 4Vita-Salute San Raffaele University, Milan, Lombardy, Italy

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It has been proven that polycystic ovary syndrome (PCOS) is associated with reduced bone mineral density (BMD) and impaired bone metabolism. However, to the best of our knowledge, neither the relationship between indices of bone turnover in adolescent girls was examined, nor were lean and overweight PCOS young females compared in this regard, which were the aims of our study.In overweight and obese (Ov/Ob) young females, concentrations of bone turnover markers, GlaOC, GluOC, and CTX-I (selective bone resorption marker), were lower than in lean PCOSs. However, this difference was statistically significant only for GlaOC. The serum activity of bone alkaline phosphatase (BAP), a bone formation index, tended to be higher in the Ov/Ob than in lean PCOS patients, although not significantly. Additionally, we observed an inverse association between low-grade inflammation, oxidative stress, androgen levels (total testosterone and/or DHEA-S), and BAP and/or GlaOC in both lean and Ov/Ob groups, together with a positive association between Total Antioxidant Capacity (TAC) and BAP. Moreover, fasting glucose, insulin, and HOMA-IR positively correlated with GluOC and BAP in lean girls.Our outcomes suggest a potential negative interaction between bone markers and immunehormonal abnormalities featuring lean and Ov/Ob adolescent PCOS girls.Moreover, these findings suggest a positive interaction between bone metabolism and total antioxidant capacity, and insulin and glucose management exists in the body. Kod pola został zmieniony Kod pola został zmieniony Kod pola został zmieniony Kod pola został zmieniony Kod pola został zmieniony Kod pola został zmieniony Kod pola został zmieniony Kod pola został zmieniony Kod pola został zmieniony Kod pola został zmieniony Kod pola został zmieniony -sformatowano: WyróżnienieAlthough these findings require further investigation, all possible preventive measures should be taken to lower inflammation, oxidative stress, and androgen levels, also keeping bone wellbeing/homeostasis in mind.ClinicalTrials.gov Identifier: NCT04738409

Keywords: Polycystic Ovary Syndrome, Adolescent girls, Obesity, Overweight, Bone health

Received: 08 Aug 2024; Accepted: 23 Jun 2025.

Copyright: © 2025 Mizgier, Sansoni, Więckowska, Jarząbek-Bielecka, Formanowicz, Kędzia, Banfi and Lombardi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Małgorzata Mizgier, Poznan University of Physical Education, Poznan, Poland

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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