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REVIEW article

Front. Nutr.

Sec. Nutrition and Food Science Technology

Volume 12 - 2025 | doi: 10.3389/fnut.2025.1511049

This article is part of the Research TopicBioactive Compounds from Medicinal Mushrooms and Plants - Extraction and Potential Application in FoodsView all 10 articles

Natural Solutions for Diabetes: The Therapeutic Potential of Plants and Mushrooms

Provisionally accepted
Aleksandra SknepnekAleksandra Sknepnek1*Dunja MiletićDunja Miletić1Alena StuparAlena Stupar2Ana Salević-JelićAna Salević-Jelić1Viktor NedovićViktor Nedović1Aleksandra Cvetanovic KljakicAleksandra Cvetanovic Kljakic3
  • 1Faculty of Agriculture, University of Belgrade, Belgrade, Serbia
  • 2Institute of Food Technology, University of Novi Sad, Novi Sad, Vojvodina, Serbia
  • 3Faculty of Technology, University of Novi Sad, Novi Sad, Vojvodina, Serbia

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Medicinal plants and mushrooms have been used for the prevention and treatment of various diseases since ancient times. For thousands of years, they have attracted significant interest due to their broad spectrum of biological activities and drug-like properties. Their continued use in traditional medicine has evolved alongside, and increasingly been supported by modern scientific research. Diabetes mellitus poses a serious global health, social and economic challenge and is among the most rapidly growing health issues of the 21st century. Type 2 diabetes mellitus (T2DM), which accounts for 90-95% of diabetes cases, is largely attributed to sedentary lifestyles, unhealthy diets and obesity. Herbal medicine has already played a key role in the development of antidiabetic drugs, as exemplified by the plant-derived origins of metformin. The development of new therapeutics or therapeutic adjuvants from natural sources offers several advantages over synthetic drugs, including improved safety profiles for long-term use, efficacy, affordability and reliance on renewable raw materials. This review highlights the potential of bioactive compounds from

Keywords: Antidiabetic properties, medicinal plants, Medicinal mushrooms, bioactive compounds, Extracts

Received: 14 Oct 2024; Accepted: 20 May 2025.

Copyright: © 2025 Sknepnek, Miletić, Stupar, Salević-Jelić, Nedović and Cvetanovic Kljakic. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Aleksandra Sknepnek, Faculty of Agriculture, University of Belgrade, Belgrade, Serbia

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material