ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1551237
Running head: Oxidative stress in preserved ratio impaired spirometry
Provisionally accepted
- Zhengzhou Central Hospital, Zhengzhou, China
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Background and aimsThe relationship between oxidative stress (OS) and preserved ratio impaired spirometry (PRISm) remains unclear. We aimed to utilize the oxidation balance score (OBS), a validated instrument for assessing the overall OS status, to investigate the association between OBS and PRISm.MethodsWe included 7,180 participants from the National Health and Nutrition Examination Survey (NHANES) data. OBS was calculated using 20 components of diet and lifestyle. Binary logistic regression analyses were conducted to investigate the association between OBS and PRISm. Subsequent analyses were performed between nonsmokers and smokers across different OBS levels.ResultsOBS was inversely associated with PRISm in all models (all p-values < 0.001). In subsequent analyses, the odds ratio (OR) for PRISm increased sequentially from nonsmokers with high OBS to nonsmokers with low OBS, smokers with high OBS, and smokers with low OBS (dose-response p-values in all models ≤ 0.003); smokers with lower OBS exhibited the highest PRISm incidence in the fully adjusted model (OR = 1.83, 95% CI = 1.27-2.64, p = 0.001).ConclusionsA lower OBS was associated with an increased incidence of PRISm, particularly among smokers, suggesting that OS may play a pivotal role in this relationship.
Keywords: Preserved Ratio Impaired Spirometry, Oxidative balance score, Oxidative Stress, dietary quality and lifestyle, antioxidant strategy
Received: 25 Dec 2024; Accepted: 15 Jul 2025.
Copyright: © 2025 Gu, Du and Gu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shengyuan Gu, Zhengzhou Central Hospital, Zhengzhou, China
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