REVIEW article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1587690
Exploring the Impact of Artificial Sweeteners on Diabetes Management and Glycemic Control
Provisionally accepted
- 1Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India
- 2College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India
- 3Dr. M.G.R. Educational and Research Institute, Chennai, Tamil Nadu, India
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Diabetes mellitus, a chronic metabolic disorder characterized by impaired glucose metabolism, has emerged as a significant global health challenge. Effective management of diabetes extends beyond medical interventions to include lifestyle and dietary modifications.Artificial sweeteners (ASs), due to their low caloric content and minimal impact on blood glucose levels, offer promising potential as sugar substitutes for individuals aiming to manage glycemic control. Compounds such as aspartame, sucralose, and stevia mimic the sweetness of sugar without causing hyperglycemia, making them suitable for diabetic patients. This chapter explores the role of ASs in diabetes management, with a special focus on their mechanisms of action, including modulation of insulin sensitivity and glucose metabolism. An extensive review of preclinical and clinical studies evaluates the efficacy, safety, and long-term effects of ASs in glycemic control, highlighting their ability to reduce caloric intake, promote satiety, and support glycemic control and insulin sensitivity in diabetic individuals. Emerging evidence suggests that ASs may influence gut microbiota, potentially affecting metabolic outcomes and insulin sensitivity, thus presenting opportunities for personalized interventions. Despite their benefits, awareness of potential risks, such as altered taste perception and over-reliance on ASs, is crucial. Integrating ASs within a broader lifestyle approach comprising regular exercise and balanced nutrition ensures optimal outcomes in diabetes management. This chapter emphasizes the importance of precision medicine in tailoring AS use to individual metabolic responses, underscoring their role as adjuncts to comprehensive diabetes care strategies.
Keywords: Kamrup, Assam, India, Pin: 781101 Artificial sweetener, diabetes, glycemic control, Blood glucose levels, insulin sensitivity
Received: 04 Mar 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Begum, S, RUSHENDRAN, M and Singh S. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ankul Singh S, Dr. M.G.R. Educational and Research Institute, Chennai, 600 017, Tamil Nadu, India
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