ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutritional Epidemiology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1587824
The joint role of systemic immune-inflammation index and geriatric nutritional risk index in cancer survivors and their impact on all-cause mortality
Provisionally accepted
- 1The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
- 2Third People's Hospital of Zigong, Zigong, China
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This study aimed to investigate the combined predictive value of the Systemic Immune-Inflammation Index (SII) and the Geriatric Nutritional Risk Index (GNRI) for all-cause mortality in cancer survivors. Using NHANES data from 1999-2018, 2,969 eligible cancer survivors were categorized into four groups based on SII and GNRI. Results showed that the combination of low SII and high GNRI was associated with the lowest risk of all-cause mortality (HR=1.0, reference group), while high SII and low GNRI significantly increased mortality risk (fully adjusted HR=6.178, 95% CI: 2.669-14.299). Both unadjusted and fully adjusted models demonstrated that high SII was associated with higher mortality risk, and low GNRI with lower risk. Subgroup analysis revealed significant interactions between gender, alcohol consumption, and the combination of SII and GNRI.The findings highlight that SII and GNRI are important predictors of all-cause mortality in cancer survivors, and their combined assessment can inform clinical interventions.
Keywords: systemic immune-inflammation index, Geriatric Nutritional Risk Index, cancer survivors, All-cause mortality, Dietary inflammatory index, NHANES
Received: 07 Mar 2025; Accepted: 10 Jun 2025.
Copyright: © 2025 Chen, Hu, Hao, Li and Yunwei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Han Yunwei, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China
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