MINI REVIEW article
Front. Nutr.
Sec. Nutrition, Psychology and Brain Health
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1598703
Role of the bed nucleus of the stria terminalis in feeding
Provisionally accepted
- 1Shandong University of Traditional Chinese Medicine, Jinan, China
- 2Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
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As an important part of the limbic system of the forebrain, the bed nucleus of stria terminalis (BNST) plays a key role in stress response, emotion regulation and motivational behavior. Recent studies have shown that BNST participates in the pathological process of appetite regulation, food selection and eating disorders by integrating metabolic signals, reward feedback and stress input. This article systematically reviews the anatomical subdivision, neural loop characteristics and multimodal mechanism of BNST in food intake regulation, discusses its association with obesity, anorexia nervosa and other diseases, and looks forward to the potential therapeutic strategies targeting BNST.
Keywords: BNST, eating behavior, Neuropeptide, neural circuit, Appetite Regulation
Received: 24 Mar 2025; Accepted: 13 Aug 2025.
Copyright: © 2025 Wang, Guo, Xu, Kuang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiqi Chen, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, Shandong Province, China
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