ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1607601
This article is part of the Research TopicLipids in Foods and Nutrition: Innovative Analytical and Biochemical InsightsView all 4 articles
The association of the atherogenic index of plasma with hypertension, diabetes, and their comorbidities in Chinese middle-aged and elderly people: a crosssectional study from CHARLS
Provisionally accepted
- 1Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
- 2Jiujiang First People's Hospital, Jiujiang, Jiangxi Province, China
- 3Jiujiang Third People's Hospital, Jiujiang, Hebei Province, China
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The atherogenic index of plasma (AIP) is acknowledged as a contemporary indicator of insulin resistance. Previous research on AIP and metabolismrelated diseases was limited and primarily concentrated on individual diseases. The aim of this investigation was to systematically examine the relationship among AIP and hypertension, diabetes, and their comorbidities.This study employed a cross-sectional design. Using data from the China Health and Retirement Longitudinal Study (CHARLS) of 2011, we conducted a systematic investigation of the association between AIP and the risk of hypertension, diabetes, and their comorbidities through restricted cubic spline plots (RCS) and multiple multivariate logistic regression. Additionally, receiver operating characteristic curves (ROC) were employed to assess AIP's predictive validity for these conditions.Results: This study comprised 8,450 participants, with an average age of 59.57 years.The prevalence of hypertension, diabetes, and their comorbidities were 40.98%, 15.62%, and 8.52%, respectively. The RCS demonstrated a non-linear positive correlation between the AIP and these disorders. For each unit increased in AIP, the risk of hypertension, diabetes, and comorbidities elevated by 0.63-fold, 2.55-fold, and 2.75fold, respectively. The ROC analysis demonstrated that AIP outperformed traditional lipid parameters in predicting both diabetes and comorbidities risk (AUC: 0.6465, 0.6725).This study demonstrated that heightened AIP was strongly linked to a high risk of hypertension, diabetes, and comorbidities among middle-aged and elderly Chinese individuals.
Keywords: Atherogenic index of plasma, Hypertension, diabetes, comorbidities, CHARLS
Received: 07 Apr 2025; Accepted: 04 Sep 2025.
Copyright: © 2025 Z, He, Zeng and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bin Hua He, Jiujiang First People's Hospital, Jiujiang, Jiangxi Province, China
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