SYSTEMATIC REVIEW article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1616476
The Effects of Probiotics Supplementation on Cardiometabolic Health in Patients with Prediabetes: A Systematic Review, Meta-analysis, and GRADE Assessment
Provisionally accepted
Rongfang Liu*
Gao Wong*- Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China
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Introduction: Previous researches have yielded conflicting results regarding the effect of probiotics on prediabetes. To address this, we did this updated systematic review and meta-analysis of existing studies to evaluate the effects of probiotics on prediabetes.We conducted a thorough search for pertinent trials on the impact of probiotics supplementation on prediabetes using various databases such as PubMed, Medline, and Google Scholar.Results: Ten RCTs were included. Probiotics supplementation significantly reduced HbA1c (WMD = -0.11; 95% CI: -0.18, -0.04; P < 0.001; I² = 0.0%), and increased HDL-C (WMD: 2.37; 95% CI: 1.02, 3.71; P < 0.001; I² = 0.0%). While, there were no significant effects of probiotics supplementation on FBS, insulin, HOMA-IR, LDL-C, TC, TG, BMI, SBP, and DBP. GRADE assessment showed high for HbA1c and HDL-C and moderate for BMI, SBP, DBP, insulin, HOMA-IR, TC, and LDL-C, and low for FBS and TG.Probiotics supplementation may HbA1c levels, and increase HDL-C in individuals with prediabetes. Future research involving large-scale, international RCTs is essential to validate its therapeutic potential further.
Keywords: Obesity, Body Weight, Body Mass Index, Meta-analysis, Probiotics
Received: 22 Apr 2025; Accepted: 31 Jul 2025.
Copyright: © 2025 Liu and Wong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Rongfang Liu, Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China
Gao Wong, Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.